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Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis
Date:10/23/2008

f achieving high Cmax:MIC

ratios in pulmonary tissues to avoid resistance development in bacteria.

-- Activity in biofilms: studies in an established in vitro biofilm system

showed that levofloxacin potency was least affected compared to

tobramycin or aztreonam.

-- Activity in anaerobic environments: antimicrobial susceptibility in

more than 100 P. aeruginosa isolates from CF patients was compared

between aerobic and anaerobic testing conditions. The geometric mean of

the MIC in levofloxacin treated isolates increased less than two fold

under anaerobic conditions, whereas tobramycin, amikacin and aztreonam

treated isolates increased 4-7 fold under anaerobic conditions. This

implies that MP-376 may retain its potency in anaerobic environments in

the lung more effectively compared to other classes of antibiotics.

-- Activity in CF sputum: Studies of antibiotic activity in CF sputum

showed that levofloxacin retained its full antibacterial activity

against P. aeruginosa whereas tobramycin activity was decreased by 1-2

logs in the presence of CF sputum, consistent with previous studies.

-- Convenient dosing regimen: In an in vivo model of a chronic lung

infection due to P. aeruginosa, MP-376 showed comparable antibacterial

activity when administered once or twice per day. In contrast, current

treatment options must be administered at least 2-3 times per day for

optimal activity.

In addition to these preclinical studies, Mpex is also presenting data at the NACFC meeting indicating that MP-376 has anti-inflammatory activity that is independent of its antibacterial effect. This was demonstrated in both in vitro and in vivo models and includes effects on both IL-6 and IL-8, cytokines which have both been implicated in destructive inflammatory processes in CF lungs. Th
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SOURCE Mpex Pharmaceuticals, Inc.
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