Mpex Pharmaceuticals Presents New Data on MP-376 in Cysti... (rtcomings of availableinhaled antibiotic...)

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

Date:10/23/2008

rtcomings of available inhaled antibiotic formulations for CF patients. These shortcomings include the following:

-- Low potency against P. aeruginosa

-- Lack of activity against other common CF pathogens

-- Potential for rapid resistance development

-- Suboptimal activity in biofilms, a factor that contributes to chronic

infections in CF patients

-- Reduced potency in anaerobic environments common in the CF lung from

thickened mucous layers

-- Reduced antibacterial activity in CF sputum

-- Inconvenient dosing regimens that reduce patient compliance

Preclinical results presented at the meetings this week show MP-376 offers potentially substantial improvements in each of these areas:

-- Potency: MIC90s for MP-376 against nearly 300 P. aeruginosa clinical

isolates from CF patients were at least 4-fold lower than those obtained

for tobramycin, amikacin and aztreonam.

-- Spectrum: MIC90s for MP-376 against clinical isolates for other common

CF pathogens such as B. cepacia, S. maltophilia and A. xylosoxidans were

substantially lower than for these other antibiotics. Previous in vitro

work has also shown superior potency of MP-376 compared to other agents

against gram positive bacteria commonly found in CF patients.

-- Resistance: in an in vitro model of resistance development in P.

aeruginosa, doses of levofloxacin formulated as MP-376 at levels

consistent with that which can be achieved with aerosol administrations

demonstrated rapid bacterial killing with no development of resistance

over the course of 4 days. In contrast, doses of levofloxacin mimicking

human exposures following systemic administration showed initial

bacterial killing, but allowed for resistance development within 24

hours. This demonstrates the importance o
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