Mpex Pharmaceuticals Announces Initiation of a Phase 2 Clinical Trial of Aerosol MP-3...(ntially result in slowing decline in lun...),Health

Date:11/3/2008

ntially result in slowing decline in lung function, improving quality of life, and reducing hospitalizations. We believe aerosol MP-376 is particularly well suited to confer such a benefit and we are eager to work with COPD physicians and patients to assess its potential in this indication."

Levofloxacin, the active ingredient in MP-376, has been shown in clinical studies to be active when given systemically against all of the common pathogens associated with bacterial exacerbations in COPD patients. By delivering the novel MP-376 formulation via the aerosol route, levofloxacin can be delivered directly to the lungs at much higher concentrations than can be achieved through usual oral and intravenous routes of administration. High concentrations are important to maximize bacterial killing and reduce the potential for development of drug resistance. Systemic exposures to levofloxacin are expected to be low when aerosol administration of MP-376 is used, potentially reducing the incidence of systemic side effects. MP-376 is also in clinical trials for potential use as a maintenance treatment in patients with cystic fibrosis.

About COPD

There are more than 9 million patients with COPD in the U.S. Approximately 10% of these patients are characterized as having severe disease which typically results in multiple acute exacerbations per year. These respiratory exacerbations are a major cause of disability, morbidity, mortality and healthcare expenditures. There is no cure for COPD and as such, current treatment is aimed at managing symptoms and preventing exacerbations.

About Mpex Pharmaceuticals

Mpex Pharmaceuticals is a clinical stage biopharmaceutical company whose mission is to develop important new therapies to combat the growing issue of antibiotic resistance. The company's internal development pipeline focuses on combining proprietary formulations, PK/PD strategies and novel potentiating agents with proven antibiotics to overcome or
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SOURCE Mpex Pharmaceuticals, Inc. Copyright©2008 PR Newswire. All rights reserved

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