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Mortality Data Presented for Patients Treated with Efient®/Effient® (Prasugrel) Who Underwent Isolated Coronary Artery Bypass Surgery
Date:11/16/2010

with prasugrel produced a statistically significant 18 percent reduction in the relative risk of the combined measure of cardiovascular death, nonfatal heart attack or nonfatal stroke compared with clopidogrel in people with chest pain at rest or milder heart attacks (UA/NSTEMI) and a 21 percent reduction in the combined endpoint in people with more severe heart attacks (STEMI). In TRITON-TIMI 38, patients treated with prasugrel also experienced a 50 percent relative risk reduction in stent-related clots when compared with clopidogrel, regardless of stent type.  Additionally, a retrospective analysis of TRITON-TIMI 38 showed that treatment with prasugrel resulted in a 26 percent reduction in the primary endpoint of cardiovascular death, myocardial infarction or stroke compared with clopidogrel among patients aged 75 years or younger who weighed at least 60 kg and had no known history of stroke or TIA.(6)

In the TRITON-TIMI 38 trial, the risk of non-coronary artery bypass graft (non-CABG) major bleeding, including fatal bleeding, was higher with prasugrel (2.2 percent incidence) compared with clopidogrel (1.7 percent incidence).(4,5) Compared with the overall study population, a higher risk of serious bleeding among prasugrel patients was most evident in three distinct patient populations that are readily identifiable: patients who weighed less than 60 kg, patients who were 75 years of age or older and patients who have had a prior transient ischemic attack (TIA) or stroke. A 5 mg maintenance dose is recommended for patients who weigh less than 60 kg. Prasugrel is generally not recommended for use in patients 75 years or older. If treatment is deemed necessary, a 5 mg dose of prasugrel may be used after careful risk-benefit evaluation. Patients with prior TIA or stroke should not be treated with prasugrel.  

About Prasugrel

Daiichi Sankyo Company, Limited, and Eli Lilly and Company co-developed prasugrel, an oral antiplatelet
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SOURCE Eli Lilly and Company
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