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Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials
Date:4/1/2008

Trofile to be used to screen patients for clinical program of monoclonal

antibody to CCR5

SOUTH SAN FRANCISCO, Calif., April 1, 2008 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc., (Nasdaq: MGRM) announced today that it had entered into an agreement with Progenics Pharmaceuticals, Inc. (Nasdaq: PGNX) to provide resistance and tropism testing for Progenics' clinical development program of PRO 140, an investigational CCR5 monoclonal antibody being studied for the treatment of HIV. In its ongoing phase 2 studies, Progenics is using Monogram's Trofile(TM) tropism test to screen and monitor HIV infected individuals whose virus uses the CCR5 receptor as a portal of entry to healthy cells. Progenics is also using Monogram's PhenoSense GT(TM) assay to measure viral resistance to drugs from other HIV-1 treatment classes.

"We are pleased to play such an important role in the development of this promising new HIV therapy," said Chris Petropoulos, Monogram's Chief Scientific Officer. "Monogram continues to help pave the path for many of the most highly anticipated new HIV drugs in development."

Trofile is a patient selection co-receptor tropism assay that determines whether a patient is infected with a strain of HIV that uses the CCR5 co- receptor, the CXCR4 co-receptor, or a combination of CCR5 and CXCR4 to enter cells. Trofile is the only clinically validated tropism assay and has been used to select patients in all phase 2 and phase 3 studies of CCR5 antagonists to date.

About PRO 140

Progenics announced the start of the phase 2 program for PRO 140 in January 2008. PRO 140 is a novel monoclonal antibody that binds CCR5 and is designed to prevent HIV from entering immune system
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SOURCE Monogram Biosciences, Inc.
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