Navigation Links
Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC)
Date:4/26/2008

Genomics improves our ability to target experimental cancer treatments

A promising new drug is in hand, and more are on the way

Improved ability to select patients to test particular drugs

MILAN, Italy, April 27 /PRNewswire/ --

At today's sessions of this, the final day of the 43rd Annual Meeting of the European Association for the Study of the Liver (EASL), leading hepatologists described several important advances in understanding and provide novel treatments for hepatocellular carcinoma (HCC). Most notably, progress has been made by acquiring data that improve our understanding of the disease process at the molecular level... what is taking place in the body that leads to the development of HCC.

Applying the technologies of genomics and microarrays, scientists have discovered that there are a number of different biological pathways that result in HCC. Using this knowledge, they can now classify and explore various subtypes of HCC. This novel view contradicts the previous belief that the disease occurs in one way only, from a single disease mechanism.

The discovery of subtypes has significant implications. First, it raises the possibility of targeting treatments to particular patients, based on their respective cancer subtype ("targeted therapeutics"). Second, it enables more precise assessment of the response to specific experimental therapies. Moreover, it offers the possibility of refining each patient's prognosis, again based on his or her cancer subtype.

Malignancy is a complex process. It involves the accumulation of multiple independent gene mutations that lead to deregulation of cell pathways that influence cell growth and cell fate. The process itself is called the "oncogenic pathway." In the past, most scientists in the field believed that there was only one oncogenic "pathway" in HCC.

HCC is one of the most common tumors worldwide. Most cases of HCC result from a viral infection (Hepatitis B or C) or from cirrhosis. Obesity is an additional, recently recognized risk factor for HCC. Treatment options of HCC and prognosis are dependent on various factors, but chiefly on tumor size and staging.

Only a minority of hepatocellular carcinomas can be removed completely using surgery, and the tumor tends to recur. Other techniques are available to halt tumor progression, including percutaneous therapies such as radiofrequency ablation.

According to Professor Massimo Levrero, Associate Professor of Medicine at Italy's University of Cagliari, and Head of the Laboratory of Gene Expression, Fondazione Andrea Cesalpino, University of Rome La Sapienza, "Molecular approaches are starting to pay off. The years 2007 and 2008 are the 'years of the drug' for HCC. We now have Sorafenib, the first molecular targeted therapy for HCC that has been proven effective in a large clinical trial of patients with advanced cancers. Other drugs are coming soon. While Sorafenib is an efficient drug, our results need to be improved. We want to increase the cytotoxic potential of our treatments by combining drugs that can theoretically yield a synergistic effect. With recent advances regarding HCC subtypes, we know which patients can be selected for response to particular experimental therapies."

Scientists are continuing their search for the genes that are dysregulated in HCC. It is hoped that by improving our ability to identify aberrant genes, research will lead to the identification of new and more powerful pharmacological interventions for HCC.

About EASL

The European Association for the Study of the Liver (EASL) aims to promote investigation into liver disease and improve the treatments that currently exist for these conditions. The association, through its annual meetings, seeks to inform and educate both the scientific community as well as society in general about the increasing occurrence of liver diseases along with the importance of understanding these conditions in order to treat and prevent them. Since its creation in 1966, the EASL congress has been hosted in 20 different European countries. Currently the association has over 1400 members and the annual congress attracts over 6000 delegates from over 65 countries each year.


'/>"/>
SOURCE EASL - European Association for the Study of the Liver
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Protein Tomography(TM) Reveals Molecular Mode of Action of Humax-EGFr Published in PNAS
2. Gen-Probe Begins U.S. Clinical Study of Molecular Test for Human Papillomavirus, Which Causes Cervical Cancer
3. Molecular Science Could Further Improve Leukemia Survival, Say St. Jude Researchers
4. Oncology Drug Development Update - Molecular Profiling Redefines the Nature of Malignancy and Increases the Adoption of Targeted Therapeutics
5. QIAGEN and Center for Molecular Medicine Create Research Collaboration for Molecular Diagnostic Markers for Breast Cancer, Other Womens Health Issues
6. Molecular Therapy Succeeds in Preventing Craniofacial Birth Defect in Mice
7. Molecular Biometrics Hires Denny Sakkas, PhD Renowned Yale Embryologist and International Thought-Leader, as Chief Scientific Officer; Opening U.S. Research Facility
8. Beckman Coulter Announces Licensing Agreements for Molecular Tests with National University of Ireland, Galway
9. Study of Pathwork Diagnostics Tissue of Origin Test Published in the Journal of Molecular Diagnostics: Investigates Test Reproducibility in Multiple Labs to Determine Primary Tumor in Cancer Cases
10. Study Shows That Low-Molecular Weight Heparin (LMWH) was Associated with Reduced Hospital Costs of Venous Thromboembolism (VTE) Treatment Compared with Unfractionated Heparin (UFH)
11. Access Pharmaceuticals Announces Two Poster Presentations Reporting Significant Preclinical Data on ProLindac(TM) at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
Breaking Medicine Technology:
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
Breaking Medicine News(10 mins):