Modigene Platform Validated in Independent Phase III Trial of CTP ...( - Validates the Clinical Utility of M...),Health

- Validates the Clinical Utility of Modigene's CTP Technology for Extending

the Duration of Action of Therapeutic Proteins -

NES-ZIONA, Israel, July 10 /PRNewswire-FirstCall/ -- Modigene Inc., (OTC Bulletin Board: MODG) today noted the successful completion of a Phase III clinical trial by Schering-Plough of long-acting fertility hormone corifollitropin alfa (FSH-CTP). FSH-CTP uses the naturally occurring CTP peptide to extend the duration of action of the hormone. Modigene is using the same naturally occurring CTP peptide to extend the duration of action of other therapeutic proteins and peptides. Schering-Plough licensed the CTP technology from Washington University for use only with four endocrine hormones. Modigene has an exclusive license from Washington University to the CTP technology for use with all other proteins and peptides. Modigene is currently applying the CTP technology to extend the duration of action of human growth hormone and interferon beta, with the goal of reducing the number and frequency of injections required to treat patients requiring continual injections of these proteins.

"The success of Schering-Plough's Phase III trial of its long-acting FSH fertility hormone marks a major milestone for the CTP platform technology that is the basis for our new drug pipeline," said Avri Havron, Ph.D., CEO of Modigene. "We believe these positive results provide independent support of our own plans for clinical trials of Modigene's CTP-enhanced versions of human growth hormone and interferon beta that we intend to initiate next year."

On July 8, 2008 Schering-Plough announced successful top-line data from its Phase III ENGAGE trial demonstrating that women receiving a single injection of FSH-CTP achieved the same pregnancy rates as women receiving seven consecutive daily injections of FSH, a primary endpoint of the study. This 1,509 patient trial was the largest double-blind fertility trial ever conducted.

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