Navigation Links
Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP
Date:1/15/2009

- Single Injection in Primates Containing 1,000-Times the Dosage Recommended for Humans Shows No Adverse Effects -

- Half-Life and AUC Support the Potential for Weekly or Bi-Monthly Dosing Frequency -

NES-ZIONA, Israel, Jan. 15 /PRNewswire-FirstCall/ -- Modigene Inc. (OTC Bulletin Board: MODG) today reported results from a pilot toxicity study in primates designed to assess the safety of hGH-CTP, its long-acting human growth hormone (hGH), as well as to provide preliminary information on the approximate injection frequency that will be needed in human patients. The study was designed to elicit potential adverse effects from a single, very large dose of hGH-CTP, also known as MOD-4023. No adverse effects were observed, and the data from this study also support once-weekly or bi-monthly injection frequency in humans.

The pilot study included a group of primates that received a single injection of hGH-CTP containing a dose that was 1,040 times the daily dose of growth hormone recommended for use in human patients. No adverse effects were observed in any of the primates. In addition, the half-life and AUC (area under the curve) of hGH-CTP as measured in primates support a potential once-weekly or bi-monthly injection frequency in humans. This would replace the multiple injections per week that are currently required, as there is presently no long-acting hGH on the market.

"Our long-acting hGH-CTP has exhibited excellent safety in all preclinical studies to date, so we were not surprised by these first data in primates showing that huge single doses of hGH-CTP appear very safe," said Dr. Avri Havron, CEO of Modigene. "We also were pleased to report a significant increase in the half-life of hGH-CTP as we moved from rats to primates, in line with industry-accepted extrapolation models for the expected increase in the half-life of therapeutic proteins between these species. Based on the res
'/>"/>

SOURCE Modigene Inc.
Copyright©2009 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Study Published in Endocrinology Reports Potential of Modigene Technology to Extend Duration of Protein Drugs
2. Modigene Platform Validated in Independent Phase III Trial of CTP Technology
3. Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta
4. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
5. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
6. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
7. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
8. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
9. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
10. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
11. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)....25/PRNewswire/-- ChemoCentryx,Inc.,announcedtoda...T-1(theProspectiveRandomizedOralTherapyEvaluationi...patientswithmoderate-to-severeCrohn,sdiseasedemons...abilityprofile.Thestudydemonstratedevidenceofclini...dasa70-pointdecreaseintheCrohn,sDiseaseActivityInd...
(Date:11/24/2009)...ewswire-FirstCall/--QuestDiagnosticsIncorporated(N...sting,informationandservices,announcedthatitissche...onferenceinNewYorkCity.Thepresentationisscheduledf..., Duringtheconference,thecompanywillreaffirmits...ingincometoexceed18%ofrevenues,anddilutedearningsp...
(Date:11/24/2009)...wswire/--Inadditiontofamily,friendsandhealth,cance...herThanksgivinggratitudelist. ,, "Theyheardthef...aidofMonday,sverdictstotaling$103millionindamagesa...2,000womennationwidewhohavesuedWyethandPfizerpharm...ndPrempro.Wisneskiandtheothervictimsofhormonethera...
Breaking Medicine Technology:ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 2ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 3ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 4ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 5Quest Diagnostics To Speak At The 21st Annual Piper Jaffray Healthcare Conference 2Maryland Woman Thankful for Wyeth Verdicts 2Ovarian Cancer Coalition Partners With Consuelo Vanderbilt Costin 56921 1Ovarian Cancer Coalition Partners With Consuelo Vanderbilt Costin 56921 2Air Quality Sciences Achieves Re Accreditation as the US Indoor Air Quality Testing Partner for Europes Coveted Blue Angel Program 56918 1Air Quality Sciences Achieves Re Accreditation as the US Indoor Air Quality Testing Partner for Europes Coveted Blue Angel Program 56918 2Air Quality Sciences Achieves Re Accreditation as the US Indoor Air Quality Testing Partner for Europes Coveted Blue Angel Program 56918 3AOBO Launches New OTC Product to Treat Throat Inflammation 14001 1AOBO Launches New OTC Product to Treat Throat Inflammation 14001 2
...al , AUSTIN, Texas--(BUSINESS WIRE)--May 30, 2007-...ed today the publication of,data describing the dr...n in a patient with a rare inherited form of cance...isorder characterized by,inherited mutations in th...orted treatment of Li-Fraumeni tumors with a thera...
...2007 - Gilead,Sciences, Inc. (Nasdaq:GILD) today a...udy of aztreonam lysine for inhalation for,the tre...e,pulmonary Pseudomonas aeruginosa (P. aeruginosa)...y 28 from baseline in respiratory,symptoms, as ass...,(CFQ-R), a patient-reported outcome (PRO) tool us...
Other Medicine Technology:Introgen's Advexin Demonstrates Clinical Benefit in Inherited,Cancer 2Introgen's Advexin Demonstrates Clinical Benefit in Inherited,Cancer 3Introgen's Advexin Demonstrates Clinical Benefit in Inherited,Cancer 4Gilead Announces Achievement of Primary Efficacy Endpoint in Second,Phase III Study of Aztreonam Lysine for Inhalation in Patients With,Cystic Fibrosis 2Gilead Announces Achievement of Primary Efficacy Endpoint in Second,Phase III Study of Aztreonam Lysine for Inhalation in Patients With,Cystic Fibrosis 3Gilead Announces Achievement of Primary Efficacy Endpoint in Second,Phase III Study of Aztreonam Lysine for Inhalation in Patients With,Cystic Fibrosis 4Gilead Announces Achievement of Primary Efficacy Endpoint in Second,Phase III Study of Aztreonam Lysine for Inhalation in Patients With,Cystic Fibrosis 5
(Date:11/26/2009)... David Kim of the Live Life Again Center, a practi...e of a growing number of physicians who are takin...connect with individuals who are interested in sur...y. Dr. Kim is utilizing Facebook to share before-a... with the community. , Da...
(Date:11/26/2009)...is & Ennis, P.A. is offering free nationwide c...min birth control pills who have suffered a Deep V...Heart Attack or other related cardiac issues or ha...ree at 1-800-856-6405 or go to the firm’s we... online case evaluation form. , ...
(Date:11/25/2009)....25/PRNewswire-FirstCall/-- OnyxPharmaceuticals,I...hosttwoinvestoreventsinDecember: ,, ASHBriefi... ,, Principalinvestigatorswilldiscussdatapres...ractorymultiplemyeloma,asfeaturedatthe51stAmerican...inNewOrleans,LA.Theteleconferencewillbeginat9:00a....
(Date:11/25/2009)...25/PRNewswire/--Thanksgivingmealswillbedeliveredto...BeachareathankstoFaithInAction/VolunteerActionforA...visionofSCANHealthPlan.Formorethan17yearstheseorga...warmThanksgivingmealstoseniorsinneedinLongBeach,La...undingcities. ,, "Ourwarmholidaymealsaredeliver...
(Date:11/25/2009)...RNewswire/--TheBayAreaAirQualityManagementDistrict... Air Alert forThursday,November26,2009whichb...fuel,bothindoorsandoutdoors. ,, "Cold,stillweat...idJackBroadbent,executiveofficeroftheAirDistrict."...irneighborsandfellowcommunitymembersthisThanksgivi...
Breaking Medicine News(10 mins):Health News:Dallas Texas Weight Loss Surgeon Using Social Media To Reach Out to Patients 2Health News:Dallas Texas Weight Loss Surgeon Using Social Media To Reach Out to Patients 3Health News:Ennis & Ennis, P.A. Announces Nationwide Free, Confidential, Consultations For Users Of Yaz And Yasmin Birth Control Pills 2Health News:Ennis & Ennis, P.A. Announces Nationwide Free, Confidential, Consultations For Users Of Yaz And Yasmin Birth Control Pills 3Health News:Onyx Pharmaceuticals Announces December 2009 Investor Events 2Health News:SCAN Employees and Community Volunteers to Help Deliver One Thousand Thanksgiving Meals to Homebound Seniors 2Health News:Winter Spare the Air Alert in Effect for Thursday, November 26, 2009 2
...ns of deep concern and disappointment about report...orward without addressing several issues that are ...ies were sent today to congressional leaders by th... and medical student members of ACP. , Dr. Dale t...
... 20, 2007) A Jekyll-Hyde mechanism that both prot...be the basis for new cancer-fighting drugs. , Sci...n Lindquist have discovered that a certain transcr...s the survival of cancer cells. , According to t...
...ose research is challenging conventional thinking ...fit cardiac patients, has secured funding to furth...from the Universitys Faculty of Biological Science...For a long time the cardiovascular benefits of sta...
...he job the agency is doing , , THURSDAY, ...Americans depend on prescription medicines for hea...nt,s role in keeping those medicines safe, a new s...ged the agency,s performance as poor. , "The Ameri...
... Developments in Solid Organ Transplantation, DAL...w",is the focus of a one-day meeting scheduled for...exas. Co-sponsored by the American Society of,Tran...ents in solid organ transplantation medicine and h...
...Enables Health Care Providers to Increase ...s, SAN ANTONIO, Sept. 20 AT&T Inc. (NYSE: T ),t...folio of radio frequency,identification (RFID) tra...AT&T is the first network services company to prov...
Other Medicine News:Health News:'Deep concern and disappointment' with exclusion of Medicare from SCHIP legislation 2Health News:'Deep concern and disappointment' with exclusion of Medicare from SCHIP legislation 3Health News:Heat shock proteins are co-opted for cancer 2Health News:Research to shed new light on how statins benefit heart patients 2Health News:Americans Confused About FDA and Drug Safety 2Health News:Americans Confused About FDA and Drug Safety 3Health News:Americans Confused About FDA and Drug Safety 4Health News:Dallas-Area Transplant Meeting Puts Spotlight on Key Issues 2Health News:AT&T Offers 'Network Industry-First' RFID Solution for Health Care Organizations 2Health News:AT&T Offers 'Network Industry-First' RFID Solution for Health Care Organizations 3
...Mist™ HME product line has the right product... and from intubated patients to patients with trac...ation for both anesthesia and critical care applic...de maximum protection for patients and staff membe...
...Mist™ HME product line has the right product... and from intubated patients to patients with trac...ation for both anesthesia and critical care applic...de maximum protection for patients and staff membe...
...Mist™ HME product line has the right product... and from intubated patients to patients with trac...ation for both anesthesia and critical care applic...de maximum protection for patients and staff membe...
...roscopic condenser humidifiers (HCH) capture the p... in the inspired gas. Small and compact, they are ...groscopic benefits. Depending on the tidal volume ...ume model., ,The adult HCH is ideal for patient t...
Medicine Products: