Navigation Links
Modified Insulin Most Effective For Controlling Post-Meal Blood Sugar Levels

ROCKVILLE, Md., Sept. 15 /PRNewswire-USNewswire/ -- Pre-mixed insulin analogues, a modified form of conventional pre-mixed human insulin, are more effective than long-acting analogues for controlling high blood sugar levels after meals in patients with type 2 diabetes, according to a report funded by the Agency for Healthcare Research and Quality, part of the U.S. Department of Health and Human Services.

Conventional pre-mixed human insulin, however, appears to be equally effective as pre-mixed insulin analogues for lowering blood sugar levels when patients go eight or more hours without eating, according to the report. A version of the analysis is available on-line in the Annals of Internal Medicine.

Type 2 diabetes accounts for more than 90 percent of diabetes. The number of Americans diagnosed with type 2 diabetes tripled from 5.6 million in 1980 to 15.8 million in 2005. Obesity increases the risks of developing type 2 diabetes. Diabetes can cause serious problems with the heart, kidneys, eyes and nerves. Many patients with type 2 diabetes control their blood sugar through diet and use of oral medications. Recent research suggests that good blood glucose control can reduce loss of sight, kidney failure, and heart disease.

The new report was compiled by the Johns Hopkins University Evidence-based Practice Center in Baltimore, one of 14 such centers that are funded by AHRQ through its Effective Health Care program. The report represents a systematic review of 45 research studies and is intended to provide unbiased, evidence-based information so that patients, clinicians and others can make the best possible treatment decisions.

"While it is clear that pre-mixed insulin analogues offer certain advantages to patients with diabetes, what is good for one patient may not be good for another," said AHRQ Director Carolyn M. Clancy, M.D. "This report offers an important reminder that patients with diabetes should review their treatment plans carefully with their physician."

Pre-mixed insulin analogues are a modified form of conventional pre-mixed human insulin. AHRQ's report compared pre-mixed insulin analogues with conventional pre-mixed human insulin, oral diabetes drugs, and two other kinds of insulin analogues -- long-acting (or "basal") analogues, and rapid-acting (or "bolus") analogues.

Although non-insulin oral medications are used as a first-line treatment for patients with type 2 diabetes, insulin is frequently required at some stage during the course of the disease. Under such circumstances, some patients are controlled with long-acting insulin alone while others need a combination of long-acting and rapid-acting insulins to control blood sugar levels after meals, especially meals with high sugar content.

About 28 percent use some form of insulin to control blood sugar levels and limit complication risks from type 2 diabetes. Pre-mixed insulin analogues, approved in the U.S. in 2003, are produced by genetically modifying selected proteins of human insulin. Insulin analogues were developed as an alternative to conventional pre-mixed human insulin to provide tighter control of blood sugar levels.

Additional findings in AHRQ's new report:

-- Long-acting insulin analogues appear to be more effective than pre-mixed insulin analogues in lowering fasting blood sugar levels.

-- Pre-mixed insulin analogues are better than long-acting analogues alone in lowering blood sugar levels after a meal with high sugar content.

-- Pre-mixed insulin analogues are more effective than long-acting analogues in lowering Hemoglobin A1c, which is a highly reliable indicator of chronic high blood sugar.

-- Pre-mixed insulin analogues are more effective than non-insulin antidiabetic medications in lowering fasting blood sugar levels.

-- Pre-mixed insulin analogues are more likely than long-acting analogues to be associated with hypoglycemia (blood sugar so low that it can cause symptoms such as fainting), and are similar to pre-mixed human insulin preparations in terms of the frequency of hypoglycemia reported.

-- Pre-mixed insulin analogues are associated with a higher frequency of hypoglycemic events than oral antidiabetic (non-insulin) agents are.

The report, Comparative Effectiveness, Safety and Indications of Pre-mixed Insulin Analogues for Adults With Type 2 Diabetes, is available at It is the newest analysis from AHRQ's Effective Health Care Program, authorized by Section 1013 of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003. That program supports important federal efforts to comparing alternative treatments for health conditions while making the findings public. The program is intended to help patients, doctors, nurses, and others choose the most effective treatments.

SOURCE Agency for Healthcare Research & Quality
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study
2. Sanofi Aventis: People With Type 2 Diabetes Treated With LANTUS(R) and APIDRA(R) Achieved Greater Reductions in A1C Than Those Treated With Pre-mixed Insulin
3. Oramed Pharmaceuticals Chosen to Present Oral Insulin Trial Results at EASD Conference (September 7-11, Rome)
4. Insulin Analogues From Novo Nordisk, Eli Lilly and Sanofi-Aventis Will Drive Growth in the Type 1 Diabetes Drug Market
5. Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling
6. New Survey Explores the Impact of Insulin Injections and Communications Between Patients and Healthcare Providers
7. Oramed Pharmaceuticals Announces Successful Phase 2A Clinical Trial of its Oral Insulin Capsule
8. Treatment Corrects Severe Insulin Imbalance in Animal Studies
9. Oramed Pharmaceuticals to Hold Conference Call on August 6 to Present Results of Phase 2A Oral Insulin Capsule Clinical Trials
10. Newly Published Study Results Showed That Two Mealtime Insulin Dosing Algorithms Were Effective for Patients with Type 2 Diabetes
11. Emisphere Announces Data From Independent Clinical Study of Effects of Oral GLP-1 on Glucose and Insulin Concentrations
Post Your Comments:
(Date:11/27/2015)... , Nov. 27, 2015 Research and ... the "Global Intrauterine Devices Market 2015-2019" report ... --> In this report, the author the ... devices market for 2015-2019. To calculate the market size, ... following type of products: Hormonal IUDs and copper IUDs. ...
(Date:11/26/2015)... 26, 2015 Un nuevo enfoque ... para el cáncer avanzado.   --> ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... inmunoterapia con la terapia fotodinámica de Bremachlorin para el ... . --> Clinical Cancer Research . ...
(Date:11/26/2015)... Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische ... ) --> ...      (Photo: ) ... Universitair Medisch Centrum (LUMC) blijkt ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... , ... There is only one major question facing all law firms in ... question has not been an easy question to answer. Especially when the senior partners ... workforce don’t share the same discipline around working long hours. , In addition ...
(Date:11/27/2015)... ... 27, 2015 , ... According to an article published November 13th ... in Washington D.C. revolved around the fact that proper dental care, both at-home and ... the link between periodontal disease (more commonly referred to as gum disease) and diabetes. ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an ... the University of Toronto and the University of British Columbia suggested that laws requiring ... injuries. The article explains that part of the reason for the controversial conclusion is ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... the way that they are handling security in light of the recent terrorist attacks ... in an attempt to stop an attack from reaching U.S. soil. Especially around special ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... care in America. As people age, more care is needed, especially with Alzheimer’s, ... and medical professionals are being overworked. The forgotten part of this equation: 80 ...
Breaking Medicine News(10 mins):