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Modified Citrus Pectin Protects Against Vascular Hardening
Date:11/20/2012

solution to numerous chronic conditions related to inflammation, fibrosis and metastatic cancer for which there are limited conventional treatments."

Study Details
In the study, rats were given Aldo and sodium chloride salt, which increased blood pressure, inflammation, fibrosis and galectin-3 levels. Using MCP, the research team blocked excess galectin-3 with significant results. Collagen type 1 deposition, blood pressure, inflammation, fibrosis and aortic wall thickness were all reduced. Spironolactone, a pharmaceutical Aldo inhibitor, achieved similar results.

However, the side effects of spironolactone are significant while MCP is proven to achieve greater results without toxicity or side effects. Specifically, the MCP was shown to outperform spironolactone in a few key areas related to inflammation and fibrosis. MCP achieved better suppression of fibrotic markers. Importantly, MCP completely inhibited the cytokine interleukin-6 (IL-6) which plays a key role in inflammation, fibrosis, immune response and cancer/metastasis. Spironolactone only partially blocked the Aldo induced IL-6.

The team went on to test the impact of increasing Aldo in regular mice as well as in galectin-3 knockout mice unable to produce the protein. When given Aldo, the normal mice experienced the inflammation and overabundant collagen formation associated with vascular remodeling. However, the knock-out mice experienced no ill effects, supporting the conclusion that Aldo requires galectin-3 to induce the collagen type 1 synthesis and deposition associated with vascular fibrosis.

Beyond Heart Disease

This new research confirms a number of earlier studies which implicate galectin-3 in numerous conditions related to inflammation and fibrosis. In particular, it substantiates

SOURCE Better Health Publishing
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