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Mithridion, Inc. Announces New Funding and Outlines Strategy for Central Nervous System Drug Development
Date:1/11/2011

n) in AD.  MCD-386 is a highly selective agonist (activator) for the M1-type acetylcholine muscarinic receptor, effectively mimicking acetylcholine in a selective way to achieve desired therapeutic effects while minimizing side effects.  Acetylcholine is a chemical 'neurotransmitter' vitally involved in many brain functions such as memory, cognition, and attention.  MCD-386 was designed to stimulate these and other key brain functions that have been compromised by the deficit of acetylcholine that is a characteristic feature of AD, schizophrenia and many other serious central nervous system disorders.  

MCD-386 has completed Phase I single- and multi-dose clinical trials in 55 healthy volunteers, including 29 subjects who received a controlled release tablet formulation.  MCD-386CR has so far proven to be well-tolerated at the doses tested.  Extensive pharmacokinetic information obtained during the trials demonstrated sustained release of drug substance from the new formulation, and, together with new information on metabolism, provides a strong foundation for further rational development of MCD-386.

Mithridion's recently announced preclinical-stage drug candidate, designated MI-10-022, is potentially a "first-in-class" oral monotherapy for schizophrenia, and in preclinical tests has shown potential for combining therapeutic effects on cognition, a major unmet need in schizophrenia treatment, with therapeutic effects on psychosis.  It is a highly selective muscarinic M1/M4 receptor agonist.  MI-10-022 appears from extensive pharmacological testing not to bind to other major neurotransmitter receptors, such as those involved in the actions of other antipsychotic drugs.  This strongly suggests that its mechanism of action is novel and distinct from those of currently available antipsychotic drugs.

The muscarinic drug targets being pursued by Mithridion were clinically validated by the investigational d
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SOURCE Mithridion, Inc.
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