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Minster Pharmaceuticals Plc Announces Positive Results from Phase II Trial of Migraine with Aura
Date:10/24/2008

lly on tonabersat received placebo and vice versa. The tonabersat dosage was 20mg a day for the first two weeks, increasing to 40mg a day for the subsequent 10 weeks.

In line with previous experience, tonabersat was generally well tolerated by patients.

It is expected that the detailed results of the trial will be published by Professor Olesen's group in a peer-reviewed article in a leading international journal.

Tonabersat is the leading compound in an exciting new class of selective drugs known as neuronal gap junction blockers, which offer the potential to prevent the onset of migraine as a preferred alternative to acute treatment.

Minster is currently conducting the 500 patient TEMPUS trial of tonabersat in prevention of migraine in the US and Canada. This Phase IIb trial is fully enrolled and results are expected in the first quarter of 2009.

"This is the first time for more than 30 years that a drug designed specifically for migraine prevention shows significant efficacy. There is a huge need for better preventives, so these trial results are very encouraging. It is clear that tonabersat has very real potential in the preventive treatment of migraine," said Professor Jes Olesen, the principal investigator in the trial and Director of the Danish Headache Center.

"The very positive results from this Phase II trial in migraine with aura reinforce our confidence in the potential of tonabersat. These results represent a significant advance in our overall program, which we are well funded to deliver, to establish tonabersat as the treatment of choice for prevention of migraine attacks. We look forward to the results of the TEMPUS trial of tonabersat in the wider migraine population, which is on track to report out in Q1 2009," said Paul Sharpe, Minster Pharmaceuticals' Chief Executive Officer.

Notes for editors:

About Minster Pharmaceuticals plc

Minster Pharmaceuticals is a drug development company focus
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SOURCE Minster Pharmaceuticals plc
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