Navigation Links
Minster Pharmaceuticals Plc Announces Positive Results from Phase II Trial of Migraine with Aura
Date:10/24/2008

ESSEX, United Kingdom, Oct. 24 /PRNewswire-FirstCall/ -- Minster Pharmaceuticals plc (AIM: MPM), the drug development company specializing in neurological and psychiatric disorders, is pleased to announce positive results from its Phase II trial in Denmark of tonabersat in the prevention of migraine with aura. The median number of aura attacks was reduced by 68% (p=0.01) in patients receiving tonabersat when compared with placebo. This result in the primary endpoint of the study is both clinically and statistically highly significant.

A further primary endpoint showed a reduction in the number of migraine headache days. This reduction did not reach statistical significance, probably owing to the small number of patients participating in the trial and, it is thought, because some of the patients suffered a type of migraine aura that is not followed by headache.

The results also showed statistically significant effects on some of the secondary endpoints including the number of attacks of migraine headache and the number of auras followed by any headache. All secondary endpoints were numerically in favor of tonabersat compared with placebo.

Migraine with aura affects around 30 percent of migraine sufferers and is a type of migraine in which the headache is preceded by symptoms such as visual disturbances and abnormalities of speech and hearing. These aura symptoms are generally recognized as being difficult to treat with existing medications.

A total of 31 patients completed the Phase II trial, which was conducted at the Danish Headache Center at Copenhagen's Glostrup University Hospital. The principal investigator in the trial was Professor Jes Olesen, the Danish Headache Center's Director and one of the world's leading authorities on headache.

Under the trial's cross-over design, patients took either tonabersat or placebo once a day for a three-month period after which the treatment regimen was reversed such that those initia
'/>"/>

SOURCE Minster Pharmaceuticals plc
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. Addrenex Pharmaceuticals Initiates Phase 2 Trial on Its Novel Hypertension Drug, ADX415
2. Oramed Pharmaceuticals Launches Phase 1A Trials of its Insulin Suppository
3. Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis
4. /K I L L K I L L K I L L -- Oramed Pharmaceuticals Inc./
5. ViroPharma Incorporated Completes Acquisition of Lev Pharmaceuticals
6. Raptor Pharmaceuticals Announces Phase 2a Clinical Trial Initiation in Non-Alcoholic Steatohepatitis (NASH)
7. Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy
8. Peregrine Pharmaceuticals Completes Patient Enrollment in First Stage of Its Second Bavituximab Phase II Breast Cancer Trial
9. Lilly and Deciphera Pharmaceuticals Announce Licensing and Collaboration Agreement
10. Access Pharmaceuticals Presents New Data on the Companys Angiolix(R) Therapeutic Monoclonal Antibody
11. Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...ewswire/--AccordingtoMillenniumResearchGroup(MRG),...gence,thenearly$3billionUSmarketfortraumafixationd...earsdespitetherecenteconomicslowdown.MRG,s USMarke...willremainhighlydynamicoverthenextfiveyears,withco...underservedsegmentsofthetraumafixationmarket,fueli...
(Date:11/25/2009)...OHANNESBURG,November25/PRNewswire/--,iThembaPharma...dtoday,thattheyhavesignedacollaborativeagreementto...,sworldclasscomputationalchemistryandleaddiscovery...ntoprovidemedicinaland,syntheticchemistrysupportto...tnetwork.iThembaPharmaceuticalsandPyxisDiscovery,a...
(Date:11/24/2009)...ewswire-FirstCall/--Endologix,Inc.(Nasdaq: ELGX ),...orders,announcedtodaythatithasfiledamotiontostay,o...lawsuitbroughtagainstitinOctober2009byCook,Inc.The...anapolis,Indiana. ,, Endologixhasrequestedthatt...rademarkOffice(USPTO)conductsproceedingstore-exami...
Breaking Medicine Technology:US Trauma Fixation Device Market Not Seeing Signs of Slowdown 2US Trauma Fixation Device Market Not Seeing Signs of Slowdown 3iThemba Pharmaceuticals (Pty) Ltd and Pyxis Discovery B.V. Announce Collaborative Agreement to Offer a Combined Service Offering 2Endologix Files Motion to Discontinue Court Proceedings Related to Alleged Patent Infringement 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH Receptor Targeted Cytotoxic Conjugate AEZS 108 in Endometrial Cancer 14959 1AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH Receptor Targeted Cytotoxic Conjugate AEZS 108 in Endometrial Cancer 14959 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH Receptor Targeted Cytotoxic Conjugate AEZS 108 in Endometrial Cancer 14959 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH Receptor Targeted Cytotoxic Conjugate AEZS 108 in Endometrial Cancer 14959 4Genomic Health to Present at Piper Jaffray Health Care Conference 14955 1Genomic Health to Present at Piper Jaffray Health Care Conference 14955 2Satellite Healthcare and Renal Disease Survivor Elias Nasrallah Join Forces to Support the Homeless This Holiday Season 6501 1Satellite Healthcare and Renal Disease Survivor Elias Nasrallah Join Forces to Support the Homeless This Holiday Season 6501 2
...5 Million Interferon-Beta-CTP Development Program ...a Special Grant From the Israeli Office of the ...NA, Israel, Aug. 5 Modigene Inc. (OTC,Bulletin Bo...&D subsidiary,has received approval for a special ...st ("OCS") in support of the company,s development...
...-Term Clinical Study Confirms Effectiveness of Aut...he results of a two-year,representative study of k...ly renowned journal "Osteoarthritis and Cartilage"...e therapy, in which,anti-inflammatory proteins obt...to the arthritic joint., Researchers at Heinrich ...
Other Medicine Technology:Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta 2Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta 3Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta 4Orthokine Treatment is Effective for Knee Arthritis, Even After Two Years 2
(Date:11/25/2009)...rological symptoms, study finds , , WED...ide effects are among the potential problems faced...ere treated with cisplatin-based chemotherapy, a n...Norwegian men treated for unilateral testicular ca...ow-up survey conducted from 1998 to 2002. , The...
(Date:11/25/2009)...ire/-- MISSIONSkincare ®isproudtosupportGNC,s...GNC,sannualSt.Jude ThanksandGiving campaign,$1from...PER-C(TM)LipBalm willbedonatedtoSt.Jude.Additional...donationatcheckoutatoneoftheir5,000+retaillocation....Judeduringtheir2009 ThanksandGiving campaign. ,...
(Date:11/25/2009)...wnforthe4thStraightYear ,, WASHINGTON,Nov.25/...-Georgia(LCA-GA)issuedthe 4thAnnualReportCardonLun...deagainstthislethaldiseaseinthestateofGeorgia.LCA-...nalorganizationdedicatedexclusivelytopatientsuppor...er. ,, (Logo: http://www.newscom.com/cgi-bin/pr...
(Date:11/25/2009)...tal cancer also can reverse a rare stomach disorde...the disease, researchers at Vanderbilt University ...ase causes thickening of the stomach lining, sever...anemia and swelling in the feet and ankles due to ...astric cancer. Previously, the only effective trea...
(Date:11/25/2009)...e skin kill tumor cells, study finds , ,...accine delivered in a fingernail-size implant elim...s. , The method uses polymer disks, 8.5 millime...fic antigens and implanted under the skin to repro...rd University scientists who developed the implant...
Breaking Medicine News(10 mins):Health News:MISSION Skincare(R) Supports GNC's Efforts To Raise Money for St. Jude Children's Research Hospital(R) 2Health News:Lung Cancer Alliance-Georgia Issues 4th Annual State-Specific Report Card on Lung Cancer 2Health News:Vanderbilt scientists report first effective medical therapy for rare stomach disorder 2
...pulmonary syndrome (HPS) develops when an arterial...ary vascular dilatations that are often associated... of patients with liver cirrhosis undergoing evalu...ly in those with decompensated liver disease. , ...
... lead to better smoking-cessation aids , WEDNESDAY...e brain show increased activation in smokers who a...sylvania study. , The finding may boost understan...n imaging studies showing how subjects respond to ...
.... 18 Kids want help from adults,as they face a da...ectures,only scare them away. ethiKids, inc. intro...ns open during the formative pre-teen years., On ...nges related to values and skills development. Its...
...nal Association joins LaSalle as a lender under th... SANTA ANA, Calif., Dec. 18 Grubb & Ellis,Healthc...ecured revolving,line of credit with LaSalle Bank ...ion to $80,million. The line of credit is for a te...
...ts Home Front Needs of Families with Deployed Serv...FT. RICHARDSON, Alaska, Dec. 18 TriWest Healthcar...onal Guard Officer,s,Auxiliary - Friends of the Gu...president for the Alaska area at TriWest,will pres...
...nn., Dec. 18 Cumberland Pharmaceuticals is,please...ives., David L. Lowrance has been promoted to Vic...ole, he is responsible for overseeing the,company,...oining Cumberland in 2003 as Director of Finance,a...
Other Medicine News:Health News:Who is the arch-criminal in the development of hepatopulmonary syndrome? 2Health News:Smokers' Brain Centers Activate During Nicotine Cravings 2Health News:ethiKids, inc. Launches Website and Products to Address Declining Ethics in Children 2Health News:Grubb & Ellis Healthcare REIT Increases Line of Credit With LaSalle Bank to $80 Million 2Health News:Grubb & Ellis Healthcare REIT Increases Line of Credit With LaSalle Bank to $80 Million 3Health News:TriWest Contributes $12,000 to Alaska National Guard Fund 2Health News:Cumberland Pharmaceuticals Announces Appointments 2
... Laboratories is a national reference laboratory a...earch and development. ARUP offers an extensive te... in clinical and anatomic pathology. Owned by the ...lude more than half of the nation's university tea...
... Laboratories is a national reference laboratory a...earch and development. ARUP offers an extensive te... in clinical and anatomic pathology. Owned by the ...lude more than half of the nation's university tea...
... Laboratories is a national reference laboratory a...earch and development. ARUP offers an extensive te... in clinical and anatomic pathology. Owned by the ...lude more than half of the nation's university tea...
... Laboratories is a national reference laboratory a...earch and development. ARUP offers an extensive te... in clinical and anatomic pathology. Owned by the ...lude more than half of the nation's university tea...
Medicine Products: