Navigation Links
Minster Pharmaceuticals Plc Announces Positive Results from Phase II Trial of Migraine with Aura

ESSEX, United Kingdom, Oct. 24 /PRNewswire-FirstCall/ -- Minster Pharmaceuticals plc (AIM: MPM), the drug development company specializing in neurological and psychiatric disorders, is pleased to announce positive results from its Phase II trial in Denmark of tonabersat in the prevention of migraine with aura. The median number of aura attacks was reduced by 68% (p=0.01) in patients receiving tonabersat when compared with placebo. This result in the primary endpoint of the study is both clinically and statistically highly significant.

A further primary endpoint showed a reduction in the number of migraine headache days. This reduction did not reach statistical significance, probably owing to the small number of patients participating in the trial and, it is thought, because some of the patients suffered a type of migraine aura that is not followed by headache.

The results also showed statistically significant effects on some of the secondary endpoints including the number of attacks of migraine headache and the number of auras followed by any headache. All secondary endpoints were numerically in favor of tonabersat compared with placebo.

Migraine with aura affects around 30 percent of migraine sufferers and is a type of migraine in which the headache is preceded by symptoms such as visual disturbances and abnormalities of speech and hearing. These aura symptoms are generally recognized as being difficult to treat with existing medications.

A total of 31 patients completed the Phase II trial, which was conducted at the Danish Headache Center at Copenhagen's Glostrup University Hospital. The principal investigator in the trial was Professor Jes Olesen, the Danish Headache Center's Director and one of the world's leading authorities on headache.

Under the trial's cross-over design, patients took either tonabersat or placebo once a day for a three-month period after which the treatment regimen was reversed such that those initially on tonabersat received placebo and vice versa. The tonabersat dosage was 20mg a day for the first two weeks, increasing to 40mg a day for the subsequent 10 weeks.

In line with previous experience, tonabersat was generally well tolerated by patients.

It is expected that the detailed results of the trial will be published by Professor Olesen's group in a peer-reviewed article in a leading international journal.

Tonabersat is the leading compound in an exciting new class of selective drugs known as neuronal gap junction blockers, which offer the potential to prevent the onset of migraine as a preferred alternative to acute treatment.

Minster is currently conducting the 500 patient TEMPUS trial of tonabersat in prevention of migraine in the US and Canada. This Phase IIb trial is fully enrolled and results are expected in the first quarter of 2009.

"This is the first time for more than 30 years that a drug designed specifically for migraine prevention shows significant efficacy. There is a huge need for better preventives, so these trial results are very encouraging. It is clear that tonabersat has very real potential in the preventive treatment of migraine," said Professor Jes Olesen, the principal investigator in the trial and Director of the Danish Headache Center.

"The very positive results from this Phase II trial in migraine with aura reinforce our confidence in the potential of tonabersat. These results represent a significant advance in our overall program, which we are well funded to deliver, to establish tonabersat as the treatment of choice for prevention of migraine attacks. We look forward to the results of the TEMPUS trial of tonabersat in the wider migraine population, which is on track to report out in Q1 2009," said Paul Sharpe, Minster Pharmaceuticals' Chief Executive Officer.

Notes for editors:

About Minster Pharmaceuticals plc

Minster Pharmaceuticals is a drug development company focused on neurological and psychiatric disorders. Its principal pipeline assets are tonabersat, under development in the preventive treatment of migraine, and sabcomeline in schizophrenia. Worldwide rights to both compounds were acquired from GlaxoSmithKline and the compounds benefit from comprehensive safety tolerance data as a result of investment by GSK.

Tonabersat is the leading compound in an exciting new class of selective drugs designated as neuronal gap junction blockers and offers the potential to prevent the onset of migraine as a preferred alternative to acute treatment. Sabcomeline, a muscarinic partial agonist, has potential in the treatment of chronic schizophrenia.

Minster's near-term focus is on the development and commercialization of its current pipeline. Its medium term strategy is to leverage the anticipated cashflows from the current pipeline by in-licensing further compounds with the ultimate objective of creating a substantial and highly efficient drug development enterprise focused on the central nervous system.

Minster joined the AIM market in February 2005 and trades under the symbol MPM. For further information please visit .

SOURCE Minster Pharmaceuticals plc
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Addrenex Pharmaceuticals Initiates Phase 2 Trial on Its Novel Hypertension Drug, ADX415
2. Oramed Pharmaceuticals Launches Phase 1A Trials of its Insulin Suppository
3. Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis
4. /K I L L K I L L K I L L -- Oramed Pharmaceuticals Inc./
5. ViroPharma Incorporated Completes Acquisition of Lev Pharmaceuticals
6. Raptor Pharmaceuticals Announces Phase 2a Clinical Trial Initiation in Non-Alcoholic Steatohepatitis (NASH)
7. Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy
8. Peregrine Pharmaceuticals Completes Patient Enrollment in First Stage of Its Second Bavituximab Phase II Breast Cancer Trial
9. Lilly and Deciphera Pharmaceuticals Announce Licensing and Collaboration Agreement
10. Access Pharmaceuticals Presents New Data on the Companys Angiolix(R) Therapeutic Monoclonal Antibody
11. Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society
Post Your Comments:
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
Breaking Medicine Technology:
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
Breaking Medicine News(10 mins):