Microwave Treatments for Enlarged Prostate Cause Blood Press...( Monitoring medication continuance...),Health

Monitoring, medication continuance needed to reduce cardiovascular risks

ROCHESTER, Minn., April 8, 2008 /PRNewswire-USNewswire/ -- Many men who receive microwave therapy for enlarged prostates experience significant surges in blood pressure that could raise their risk of a heart attack or stroke, according to new research findings published recently in Mayo Clinic Proceedings.

The Mayo Clinic-led study of 185 consecutive patients who received transurethral microwave therapy at four medical centers found that 42 percent experienced systolic blood pressure surges of more than 30 mm Hg, while 5 percent had surges of more than 70 mm Hg.

"Men who are candidates for this minimally invasive microwave therapy tend also to be at higher risk for cardiac events," says Lance Mynderse, M.D., the Mayo Clinic urologist who authored the study. "Blood pressure surges of the magnitude identified in this study are troubling side effects of treatment that need to be monitored and managed."

Benign prostatic hyperplasia (BPH), or an enlarged prostate gland, is a condition affecting half of men over age 50 and 80 percent of those over 70. Symptoms include difficult urination, sudden urges to urinate and inability to empty the bladder. BPH often is treated with medication and in severe cases open surgery may be necessary, but since 1997 transurethral microwave therapy has been a less-invasive option.

Transurethral microwave therapy involves using a catheter to place a microwave device within the prostate, which is then heated to destroy excess tissue. Approximately 70,000 such procedures are performed each year, usually in an office setting and typically involving patients from 50 to 85 years old.

"This patient population is at high risk of cardiovascular disease," explains Benjamin Larson, a medical student at Cleveland Clinic who is the lead author of the Mayo Clinic Proceedings paper. "Anecdotal reports of adverse blood press
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