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Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients
Date:6/8/2009

of treatment with bcr-abl inhibitors, and patients with t(4;11) translocations. Side effects were observed primarily in the first 24 to 48 hours with transient pyrexia and lympho-/leukopenia being the most frequent adverse events.

"Blinatumomab is one of the most active agents the GMALL has tested in the adult ALL consolidation setting," said Dr. Ralf Bargou, principal investigator of the trial. "We are excited about the significant activity of blinatumomab in ALL and the favorable safety profile observed in this study. These results are particularly important for these patients who are in a disease stage with extremely poor prognosis and for which we lack treatment options except for patients eligible for allogenic stem cell transplantations."

"The ALL interim data showing an MRD response rate above 80% significantly exceeds the rate which was considered to be clinically meaningful and was set as the hurdle for the achievement of the primary end point," said Micromet's Senior Vice President and Chief Medical Officer, Carsten Reinhardt, M.D. "We are now looking forward to discussing a pivotal ALL program with the regulatory authorities later this year."

    (1) Topp, M.S. et al (2009). Blinatumomab (anti-CD19 BiTE(R)) for targeted
        therapy of minimal residual disease (MRD) in patients with B precursor
        acute lymphoblastic leukemia (ALL): Update of an ongoing Phase II
        study. 14th Congress of the EHA 2009, abstract no. 482


Webcast/Conference Call

Micromet will host a webcast/conference call this morning from 9:00 am to 11:00 am U.S. Eastern time to discuss the blinatumomab data presented at the 14th Congress of the European Hematology Association. The webcast will be available on the company's website at www.micromet-inc.com. To participate in the conference call, dial 866
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SOURCE Micromet, Inc.
Copyright©2009 PR Newswire.
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