Navigation Links
Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma
Date:4/14/2008

BETHESDA, Md., April 14 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel antibodies for the treatment of cancer, inflammation and autoimmune diseases, today presented at the Annual Meeting of the American Association for Cancer Research (AACR) in San Diego, CA, preclinical data of two new human BiTE(R) antibodies targeting CD33 and MCSP, for the treatment of acute myelogenous leukaemia (AML) and melanoma (1). BiTE antibodies are designed to direct the body's cytotoxic, or cell-destroying, T cells against tumor cells, and represent a new therapeutic approach to cancer therapy.

Generation of human anti-CD33 and anti-MCSP BiTE antibodies used a novel human BiTE antibody platform that is cross-reactive with non-human primates. In cell-based assays, CD33-specific and MCSP-specific BiTE antibodies were equally potent in eliminating tumor cells expressing the respective target antigens. While CD33 is present and well accessible on many normal blood cells, MCSP is barely accessible on normal cells, but is exposed and highly expressed on melanoma cells. Consistent with the accessibility of the respective target antigen, the CD33-specific BiTE antibody showed in macaques a dose-dependent depletion of CD33-expressing blood cells, whereas the MCSP-specific BiTE antibody did not show any activity, even at very high doses.

"We are very encouraged by the first in vivo results of these two new BiTE antibodies that continue to expand our novel BiTE antibody pipeline," comments Patrick Baeuerle, chief scientific officer of Micromet. "The data indicate highly target-specific activities of the two BiTE antibodies in primates, and suggest appropriate therapeutic windows for elimination of targ
'/>"/>

SOURCE Micromet, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies
2. Micromet Announces Presentation of Five Posters Related to Its Proprietary BiTE Antibody Platform at Annual Meeting of American Association for Cancer Research
3. Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
4. Micromet Announces Changes in Management Team
5. Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions
6. VIRxSYS Presents Data on HIV Vaccine at Keystone HIV Vaccine Symposia
7. NeoVista Presents One Year Data on Novel Wet AMD Therapy at Macula Society
8. Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously
9. Amicus Therapeutics Presents Data from Clinical Ex Vivo Response Study and Phase 1 Studies of AT2220
10. NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference
11. Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Equipment, Inc. for the third straight year, No. ... 500|5000, an exclusive ranking of the nation,s fastest-growing ... look at the most important segment of the ... Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and many ...
(Date:8/21/2014)... 21, 2014 BreedIT Corp., ... the exclusive worldwide license holder and distributor of ... and researchers, today is pleased to announce the ... Seach Ltd, a leading Israeli medical Cannabis breeder. ... develop new breeds of medical Cannabis to meet ...
(Date:8/21/2014)... FRANCISCO , Aug. 21, 2014 /PRNewswire/ ... Food and Drug Administration (FDA) has granted ... detect atrial fibrillation (AFib), the most common ... process (algorithm) instantly detects if patients are ... taken on the mobile phone based AliveCor® ...
Breaking Medicine Technology:Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4AliveCor Receives First FDA Clearance to Detect a Serious Heart Condition in an ECG on a Mobile Device 2
(Date:8/21/2014)... August 21, 2014 Xarelto lawsuit ( ... patients to suffer uncontrollable internal bleeding and other serious ... LLP reports. According to court documents, a wrongful death ... Court, Easter District of New York by the family ... bleeding event that was allegedly caused by Xarelto. Among ...
(Date:8/21/2014)... NY (PRWEB) August 21, 2014 ... products manufactured by Boston Scientific has begun in ... first bellwether trial. The Rottenstein Law Group LLP, ... women with claims of harm stemming from the ... a claim for compensation for injuries suffered at ...
(Date:8/21/2014)... Revista, a one-stop source for healthcare ... is “on a roll.” Today, the Annapolis-based company ... Southeast, Mid-Atlantic and Midwest areas of the country ... available, comprehensive medical property database tracking these regions. ... including existing and recently added, is 34,549. This ...
(Date:8/21/2014)... 2014 (HealthDay News) -- In a new review of ... avoid eating tuna due to concerns about mercury exposure. ... second only to shrimp as the most commonly eaten ... to avoid all tuna," Jean Halloran, director of food ... Consumer Reports, said in a news release from the ...
(Date:8/21/2014)... August 21, 2014 Sasha is a 10 ... Sasha is getting a little older, and is having trouble ... Sasha just happens to have an owner who purchased a ... had an accident, and could no longer get up and ... her finished basement. She had tried a stair lift, ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 3Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 4Health News:Transvaginal Mesh Lawsuit News: Second Boston Scientific Mesh Bellwether Trial Begins, The Rottenstein Law Group LLP Reports 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 3Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 4Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 5Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2Health News:Sasha Gets a Butler Mobility Inclined Platform Lift 2
... circulating blood and important in blood clotting, can promote ... into the brain, triggering inflammation that leads to MS-related ... Diego (UCSD) School of Medicine have identified a fibrin-derived ... models of MS, reducing MS symptoms. ,“Current ...
... A study by Drs Benjamin Kile and David Huang found ... This discovery is sure //to raise the hope of formulating ... platelets stored in blood banks. This will in turn increase ... ,An undesirable side effect of cancer chemotherapy ...
... found if given a choice of exercising alone, with ... age, most adults would rather exercise with others in ... provide useful insight into the preferences of older exercisers, ... initiatives [in communities around the world],” said lead researcher ...
... have come out with study results that encourage health care ... marked by the presence of tumor cells in ... may be a definite clue to chances of reccurence ... with risks of the cancer staging a comeback. ...
... wife Elizabeth Edwards has been diagnosed with// a recurrent case ... right rib bone and hence classified as metastatic or stage ... and underwent treatment, was cancer free for the last two ... conference in North Carolina that she had sought medical treatment ...
... study finds that improving the institutional culture (ethos) of ... on bad habits like// smoking, drinking, drug abuse and ... of Hygiene and Tropical Medicine's Centre for Research on ... teenage pregnancy are major public health challenges and argue ...
Cached Medicine News:Health News:Inhibiting Blood to Save the Brain 2Health News:Improved Platelet Life Span Increases Better Patient Care 2Health News:Exercising With Peers Has Added Appeal 2Health News:Doctors Warned to Keep Track of Tumorous Lymph Nodes 2Health News:Doctors Hopeful for Elizabeth Edwards 2Health News:Improve School Ethos to Combat Teen Evils 2
... King LT™ is a superior, disposable supraglottic ... advances in materials and design to provide ... LT™ emergency airway is a safe, reliable, ... emergency ventilation when direct laryngoscopy is not ...
All oral and nasal airways are manufactured with smooth, rounded edges for increased patient comfort and safety., ,Portex® offers a broad selection of airways for a variety of clinical applicati...
... Available in even sizes 20-36F. Single use. ... patient comfort. The Latex-Free Robertazzi is the ... offering the best solution for latex sensitivity. ... offer a quality latex-free product as your ...
Bag of 9 airways 20-36 French (1234) or 4 airways 12-18 French (1233). Includes four foil packages of lubricating jelly....
Medicine Products: