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Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells
Date:11/4/2008

BETHESDA, Md., Nov. 4 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, presented data from a preclinical study(1) showing cytotoxic activity of anti-EpCAM antibody adecatumumab (MT201) against KRAS-mutated human colon cancer cells on November 1, 2008 at the 23rd Annual meeting of the International Society for Biological Therapy of Cancer (iSBTc) , taking place October 31-November 2, 2008 in San Diego, California.

The new preclinical data indicated that human colon cancer cells are efficiently eliminated in tested cell lines by adecatumumab, mediated by antibody-dependent cellular cytotoxicity (ADCC), irrespective of their KRAS mutation status. Recent studies suggest that anti-EGFR antibodies cetuximab (Erbitux(R); ImClone, BMS, Merck KGaA) and panitumumab (Vectibix(R); Amgen) are beneficial for patients with KRAS wild-type tumors, however, show limited or no efficacy in the treatment of colon cancer patients with a mutated KRAS oncogene in their cancer cells. These findings recently led to the approval of cetuximab for first-line therapy in patients with KRAS wild-type tumors. As a consequence, there is a high need for the development of treatment strategies covering those patients who are not able to benefit from this important new treatment option as their tumors carry the KRAS mutated gene. This mutation is found in approximately 35 to 40 percent of patients with this disease.

"Given that more than 95 percent of colon cancer patients strongly express EpCAM on their tumors, and that 35 to 40 percent of patients who have a KRAS mutant tumor may not benefit from treatment with anti-EGFR antibodies, adecatumumab could be investigated as a potential alternative for the treatment of KRAS mutant colon cancer tumors," commented Patrick Baeuerle, senior vice president and chief scientific officer for Micromet.
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SOURCE Micromet, Inc.
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