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Micromet Presents Data at ESMO 2008 on Anti-EpCAM Antibody Adecatumumab (MT201) in Combination with Chemotherapy
Date:9/15/2008

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The overall response rate according to RECIST has been reported to be 43 percent in patients with high expression of EpCAM, the target of adecatumumab (3 of 7 patients), whereas no responses were detected in patients with low EpCAM expression (0 of 8 patients).

"These data demonstrate that adding adecatumumab to standard chemotherapy is feasible and suggest that the combination with taxanes could be a valuable treatment option for patients with high EpCAM expression," said Carsten Reinhardt, M.D., Ph.D., senior vice president and chief medical officer for Micromet. "The trend for a better outcome in patients with high EpCAM expression levels is in line with earlier observations and suggests a truly targeted effect of adecatumumab against EpCAM-positive tumor cells."

In addition to the continued clinical development in patients with breast cancer, Micromet is also in the process of setting up a randomized phase 2 clinical trial in patients suffering from colorectal cancer (CRC) after complete resection of first liver metastases.

(1) First results from a Phase 1b study of the anti-EpCAM antibody adecatumumab (MT201) in combination with docetaxel in patients with metastatic breast cancer. M. Schuler et al. ESMO Meeting Abstract, Sep 2008; Abstract 485P.

(2) Highly reduced incidence of new breast cancer metastases during treatment with adecatumumab appears to be the major factor for longer time to tumor progression in patients with high-level EpCAM expression Ch. Dittrich et al. AACR Meeting Abstract, Oct 2007; A71.

About ESMO

The European Society for Medical Oncology (ESMO) is the leading European non-profit professional organization for medical oncology, with a focus on promoting multidisciplinary cancer treatment around the world.

Since its founding in 1975, ESMO has continuously expanded its mission, aiming to create a wider community of people involved in the multifaceted aspects and phases of cancer: a com
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SOURCE Micromet, Inc.
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