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Micromet Highlights Clinical Plans and Regulatory Strategy for Lead Product Candidate Blinatumomab at its Annual R&D Day
Date:2/10/2010

s in the EU and US, the Company plans to design and conduct an exploratory Phase 2 single-arm study in adult patients with relapsed/refractory CLL. The Company currently plans to initiate patient enrollment by the end of 2010.

Webcast replay

A replay of the Company's R&D Day webcast, along with presentation slides, is available through a link on Micromet's web site at www.micromet-inc.com.  

About Blinatumomab

Blinatumomab (MT103) is a novel, next-generation monoclonal antibody designed to direct the body's cell destroying T-cells against CD19, a protein expressed on the surface of most B-cell derived non Hodgkin's lymphomas. Blinatumomab has demonstrated potent activity against adult Acute Lymphocytic Leukemia, achieving an 80% molecular response rate in a Phase 2 study. Blinatumomab was generally well-tolerated by patients in the Phase 2 study.  The most frequently reported grade 3/4 adverse event was lymphopenia.  All other adverse events were infrequent and transient in nature.  Micromet received orphan drug designation from the EMEA for blinatumomab for the treatment of ALL in August 2009.

About Acute Lymphocytic Leukemia

Acute Lymphocytic Leukemia (ALL) is a cancer of the blood and bone marrow that afflicts 5,760 patients in the U.S. annually.(1)  ALL is the most common type of cancer in children. The average five-year survival rate for adult ALL patients after 1st relapse is 7%.  The presence of minimal residual disease, or MRD, is a recognized negative prognostic factor for patients with ALL.  According to published results(2), MRD-negative patients incurred a 6% ri
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SOURCE Micromet, Inc.
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Related medicine technology :

1. Final Data from Phase 2 Study Confirm High Response Rate of Micromets Blinatumomab in Patients with Acute Lymphoblastic Leukemia
2. Bayer Schering Exercises Option to Develop Solid Tumor BiTE Antibody with Micromet
3. Micromet to Present at The 8th Annual BIO Investor Forum Conference on October 29, 2009
4. Micromets Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients
5. Micromet Presents Update on Blinatumomabs Response Rate and Duration in a Phase 1 Study in Non-Hodgkins Lymphoma Patients
6. Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day
7. Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells
8. Micromet Receives Milestone Payment for Filing of the First Clinical Trial Application for MT203
9. Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients
10. Micromet Key Events for 2009
11. Micromet Expands Committed Equity Financing Facility to $75 Million
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