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Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients
Date:3/23/2009

breast cancer. In this trial, patients with high levels of EpCAM expression, in a dose-dependent fashion, developed significantly less new lesions as compared to patients with low levels of EpCAM (2).

"Numerous published clinical and preclinical data suggest that therapies targeting EpCAM such as adecatumumab could prove to be highly effective anti-cancer therapeutics," commented Carsten Reinhardt, MD, Chief Medical Officer of Micromet. "We look forward to exploring the promise of adecatumumab to eliminate minimal residual disease in colorectal cancer patients and thereby to potentially improve cure rates in these patients at high risk of relapse."

Colorectal cancer is the third most common cancer in western countries with more than 145,000 new cases diagnosed in the US each year. About 25 percent of patients present with liver metastases at first diagnosis, and an additional 35 to 45 percent of patients will develop metastases during the course of their disease. The only chance of long-term survival comes with curative resection of hepatic metastasis by liver surgery with reported five and 10 year survival rates of 41 percent and 22 percent, respectively. Previous trials of combination chemotherapy regimens in these patients have demonstrated only very modest improvements in survival. Even intensified treatment regimens, such as the one recently published EORTC Intergroup trial 40983, which compared peri-operative FOLFOX plus surgery to surgery alone, demonstrated only 7% improvement in progression free survival at three years (3).

References

1) Maetzel D. et al., Nature Cell Biology 2009; 11: 162-171

2) Dittrich C. et al., AACR-NCI-EORTC meeting 2007

3) Nordlinger et al., Lancet 2008; 371: 1007

About Micromet

Micromet, Inc. (www.micromet-inc.com) is a biopharmaceutical company
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