Navigation Links
Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients
Date:3/23/2009

Randomized, Controlled, Multicenter Trial Will Test Ability of Adecatumumab to Prolong Disease Free Survival in High Risk Patients with Liver Metastases

BETHESDA, Md., March 23 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced the commencement of a randomized, controlled phase 2 trial of its human anti-EpCAM IgG1 antibody adecatumumab (MT201) for the treatment of patients with colorectal cancer (CRC) after complete resection of liver metastases. The trial has three arms comparing single agent adecatumumab to combination chemotherapy (FOLFOX: 5-FU/Leucovorin plus Oxaliplatin), and to FOLFOX followed by adecatumumab. The primary endpoint will be the disease-free survival rate at one year.

"The relapse of colorectal cancer patients with liver metastases still represents an area with very high medical need" said the trial's principle investigator, Professor Peter Neuhaus, from the Charite University Hospital in Berlin, Germany. "Recent intensification of chemotherapeutic regimens has shown only modest benefit and there is significant room for improvement in these patients. EpCAM is a cancer target which is highly expressed in colorectal cancer, and targeted therapies such as adecatumumab could become a major breakthrough in this setting if proven successful."

Apart from being the most highly and frequently expressed target antigen on colorectal cancer cells, EpCAM has recently been shown to drive tumor growth and to be expressed on colorectal cancer stem cells (1). The ability of adecatumumab to potentially control and eliminate newly developing metastases has been suggested in a recently reported Phase 2 trial of adecatumumab as monotherapy in metastatic
'/>"/>

SOURCE Micromet, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Micromet Key Events for 2009
2. Micromet Expands Committed Equity Financing Facility to $75 Million
3. Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells
4. Micromet Presents Data at ESMO 2008 on Anti-EpCAM Antibody Adecatumumab (MT201) in Combination with Chemotherapy
5. Micromet, Inc. to Host Webcast and Conference Call to Discuss Blinatumomab Data Published in SCIENCE
6. Micromet, Inc. to Host Conference Call and Webcast to Discuss Second Quarter 2008 Financial Results
7. Micromet and Nycomed Begin Formal Preclinical Safety Studies for Antibody MT203 for Inflammatory and Autoimmune Diseases
8. Micromet and MedImmune Commence Treatment in Phase 2 Trial of BiTE Antibody Blinatumomab (MT103/MEDI-538) in Patients with Acute Lymphoblastic Leukemia
9. Micromets BiTE Antibody Blinatumomab (MT103/MEDI-538) Demonstrates Durable Responses in Patients with Relapsed Non-Hodgkins Lymphoma
10. Micromet to Present Clinical Update for BiTE Antibody MT103/MEDI-538 at the International Conference on Malignant Lymphomas
11. Micromet Enrolls First Patient in a Phase 1 Clinical Trial with MT110, the First BiTE Antibody for Treatment of Solid Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... Shire plc (LSE: SHP, NASDAQ: ... Officer (CFO), has notified the Board of Directors of his decision ... career opportunity as CFO of Severn Trent plc.  James will leave ... commence a search for a new CFO immediately. Flemming ... build and lead a high-quality finance team at Shire. We are ...
(Date:10/17/2014)... CHAPEL HILL, N.C. , Oct. 17, 2014 ... healthcare landscape, the Medical Affairs function has come ... metrics, allocating resources efficiently and managing globalization.  ... at Best Practices, LLC is dedicated to providing ... issues. The Medical Affairs Consortium is a service ...
(Date:10/17/2014)... , October 17, 2014 ... ) has announced the addition of the  ... to their offering.       (Logo: ... disease in China ... changes in consumption concept, dietary habit, way ...
Breaking Medicine Technology:Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4Early Key Findings from the Medical Affairs Consortium Research 2China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3
(Date:10/20/2014)... 2014 Women’s health specialist, Dr. Amber ... Gynecology of Columbus, Inc., A Division of MaternOhio Clinical ... more than 100,000 patients annually. Dr. Murphy will provide ... stages of a women’s life. She is accepting new ... Westerville and Dublin. , Dr. Murphy offers a wide ...
(Date:10/20/2014)... Angeles, CA (PRWEB) October 20, 2014 ... fitness expertise, nutritional coaching, corporate wellness programming, authorship, international ... CPT, is excited to announce the release of the ... , After many years of coaching thousands of individuals ... nutrition tracking app that does not require calorie counting ...
(Date:10/20/2014)... Myoderm announced today the ... their CentralSource service. Matthew will play ... drug sourcing, distribution, and management service for international ... of industry experience, in both business development and ... their international success to help clients manage their ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 National Teen Driver ... of the American Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ... in encouraging parents of teen drivers to talk to their ... road. , Motor vehicle crashes are the leading cause of ... drivers involved in fatal crashes, and 859 (42%) of those ...
(Date:10/20/2014)... Punzoné , the first line of ... a lot to celebrate this month. October marks Italian Heritage ... and contributions of Americans of Italian heritage and Italians in ... it shares its favorite Italian cocktails and encourages everyone to ... even if it is only in a glass. , ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4
... of Illinois at Chicago have discovered a possible target ... can invade the bloodstream, which can lead to severe ... 750,000 people affected in the United States each year, ... Care Medicine. , "The growth of bacterial pathogens in ...
... study provides valuable insight into a previously undescribed ... research, published by Cell Press in the February ... of the fundamental processes that contribute to breast ... receptor coactivator-3 (SRC-3/AIB1) plays key roles in cell ...
... Rutgers have unlocked some of the mysteries of how ... of vitamin A present in the maternal blood stream. ... of the Journal of Biological Chemistry. , The ... facilitates the formation of vitamin A stores in the ...
... Seventh Annual American Red Cross National Celebrity Cabinet ... Cross Initiatives, WASHINGTON, Feb. 28 The ... Cabinet with fifteen new,members, Emmy Award winner Patricia ... Garth, actor Masi Oka, pro skateboarder Tony Hawk, ...
... people to stay active, helps reduce arthritis ... pain through ... today a,partnership with McNeil Consumer Healthcare, the maker of TYLENOL(R),Arthritis Pain, ... reduce arthritis pain. Through this new collaboration,participating YMCAs will introduce members ...
... The Geriatric Oncology,Consortium ("The GOC") announced today that ... to the Tampa Bay area., The GOC, a ... and educational network of Oncology healthcare,providers with a mission ... raise awareness and funds for this effort, the GOC ...
Cached Medicine News:Health News:Researchers find possible target to treat deadly bloodstream infections 2Health News:Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells 2Health News:Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development 2Health News:Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development 3Health News:Celebrities Join the American Red Cross in 2008 to Help Change Lives 2Health News:Celebrities Join the American Red Cross in 2008 to Help Change Lives 3Health News:Celebrities Join the American Red Cross in 2008 to Help Change Lives 4Health News:YMCA of the USA and McNeil Consumer Healthcare Partner to Promote Health for Older Adults 2Health News:YMCA of the USA and McNeil Consumer Healthcare Partner to Promote Health for Older Adults 3Health News:Geriatric Oncology Consortium (GOC) Announces Tampa Bay Road Rally to Raise Awareness for the Treatment of Seniors With Cancer 2
Claes Shielded Retinotomy Scissors, Vertical...
... DxSelect is intended for qualitatively detecting antibodies ... serum. The test is indicated for testing ... an aid in the presumptive laboratory diagnosis ... intended for self-testing, and this test is ...
... Indirect immunofluorescent antibody (IFA) test for ... IgG antibodies to St. Louis Encephalitis virus ... Equine Encephalitis virus (EEE), and California Encephalitis/La ... 8-well slides with fixed individual spots of ...
... immunofluorescent antibody (IFA) test ... semi-quantitation of human serum ... viral capsid antigen (VCA). ... 12-well slides, FITC IgG ...
Medicine Products: