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Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies
Date:4/14/2008

BETHESDA, Md., April 14 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, presented at the annual meeting of the American Association for Cancer Research (AACR) in San Diego, CA, data showing that commercial anti-cancer antibodies trastuzumab (Herceptin(R); Genentech, Roche), cetuximab (Erbitux(R); Bristol-Myers Squibb, Imclone, Merck Serono), and panitumumab (Vectibix(R); Amgen) can be converted to highly potent BiTE(R) antibodies (1). Likewise, the anti-IgE antibody omalizumab (Xolair(R); Genentech, Novartis) for the treatment of asthma can also be successfully converted into a BiTE antibody. BiTE antibodies are designed to direct the body's cytotoxic, or cell-destroying, T cells against selected target cells, and represent a new therapeutic approach to therapy of cancer and other diseases.

All four BiTE antibodies were constructed using Micromet's novel proprietary BiTE platform that is fully human and cross-reactive with a wide variety of non-human primates. The presentation at AACR shows that all BiTE antibodies are active in eliminating cells expressing the respective target antigens of human and macaque origin. The four BiTE antibodies with specificity for EGFR, HER2/neu and IgE target antigens, all showed high potency as demonstrated by redirected lysis of respective target cells at half maximal concentrations below 1 ng/ml (18 picomolar).

"Our data show that commercially successful monoclonal antibody therapeutics can be converted into the T cell-engaging BiTE antibody format using our new BiTE platform," comments Patrick Baeuerle, chief scientific officer of Micromet. "With
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SOURCE Micromet, Inc.
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