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Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
Date:2/12/2008

BETHESDA, Md., Feb. 12 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced the publication of a comprehensive review article entitled, "BiTE: A new class of antibodies that recruit T cells" in the journal Drugs of the Future. BiTE(R) antibodies are designed to activate the body's T cells to seek and destroy cancer cells in a tightly controlled manner.

The review article discusses recently published preclinical and clinical data on BiTE antibodies, which are evolving into a new class of antibody-based therapeutics, with several new members in various stages of development. One emphasis is on CD19-specific BiTE antibody MT103 (also known as MEDI-538), which produced complete and partial responses at generally well tolerated and very low doses in late-stage lymphoma patients. Another emphasis is on several preclinical studies showing significant anti-tumor activity of three other BiTE antibodies targeting solid tumors by EpCAM (CD326), EphA2 or CEA antigens. All three tumor-associated antigens are found on many solid tumors. In addition, the article provides a detailed description of the mode of action of BiTE antibodies, comparing it to natural T-cell responses.

"Our latest review article demonstrates the clinical progress and high level of scientific understanding the company has acquired in numerous published studies about its proprietary BiTE antibody technology," commented Patrick A. Baeuerle, Micromet's chief scientific officer. "BiTE antibodies represent a novel platform of clinically-validated, antibody-based therapeutics for the treatment of a wide range of cancers
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SOURCE Micromet, Inc.
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