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Micromet Announces Presentation of Five Posters Related to Its Proprietary BiTE Antibody Platform at Annual Meeting of American Association for Cancer Research
Date:3/18/2008

BETHESDA, Md., March 18 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, announced that five posters will be presented on April 14, 2008, at the annual meeting of the American Society for Cancer Research (AACR) to be held at the San Diego Convention Center, California. The five posters showcase recent progress on the company's proprietary BiTE(R) antibody platform and present preclinical data for new BiTE antibodies. BiTE antibodies are designed to direct the body's cytotoxic, or cell-destroying, T cells against tumor cells, and represent a new therapeutic approach to cancer therapy.

A first poster reports that BiTE antibody MT110, which has completed preclinical development for the treatment of patients with EpCAM-expressing adenocarcinoma, can be administered to primates with good bioavailability by subcutaneous delivery (abstract no. 2403).

Jointly with its partner Medimmune, a second poster is presented where BiTE antibody MT103 (MEDI-538), which is in phase 1 and 2 clinical studies, is shown to exhibit anti-tumor activity when subcutaneously delivered to mice (abstract no. 2131).

A third poster describes the conversion of the commercial antibodies trastuzumab and cetuximab (Genentech's and Roche's Herceptin(R) and Imclone Systems Incorporated, Bristol-Myers Squibb's and Merck KGaA's Erbitux(R)) into highly active BiTE antibodies.

A fourth poster presents data on the in vivo and in vitro activity of human BiTE antibodies to CD33 and MCSP for the treatment of acute myelogenous leukaemia and melanoma, respectively (abstract no. 2404).

A fifth poster explores th
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