Navigation Links
Microbicide Developer Receives License for Novel HIV Microbicide Candidate From Merck & Co., Inc.

SILVER SPRING, Md., March 11 /PRNewswire-USNewswire/ -- In a boost to HIV prevention research, Merck & Co., Inc., has agreed to provide a royalty-free license to the non-profit International Partnership for Microbicides (IPM) to develop a novel antiretroviral compound for use as a potential vaginal microbicide.

The compound, called L'644, is a member of a class of antiretroviral molecules known as gp41 fusion inhibitors, which inhibit HIV infection by preventing the virus from fusing with the surface of target cells, an early step in the HIV infection process, potentially representing a novel way to block infection.

This announcement follows a similar agreement with Merck that granted IPM a royalty-free license in 2005 to develop another compound, L'167/CMPD167, which belongs to the class of molecules known as CCR5 blockers.

Microbicides are products, such as gels or films, that could be applied vaginally to prevent HIV transmission during vaginal intercourse. IPM is also developing other delivery methods, such as long-lasting vaginal rings that would release the drug gradually over time.

"Merck deserves recognition for its exemplary commitment to HIV prevention research," says Dr. Zeda Rosenberg, CEO of the International Partnership for Microbicides. "This arrangement for L'644 helps IPM pursue development of compounds that target HIV at many points in the virus's lifecycle. We're working toward the day when millions of women around the world will have access to safe and effective microbicides -- and partnerships like this will help us get there."

Preclinical research conducted by Merck suggests that L'644 is a potent HIV fusion inhibitor that is able to block infection of T cell targets in laboratory settings. For this reason there is a strong scientific rationale for evaluating its potential as an anti-HIV microbicide. Under the terms of the agreement, Merck grants IPM full royalty-free rights to develop L'644 as a microbicide to prevent HIV infection in women in developing countries, while also collaborating with IPM to advance early stage product development research efforts.

"Merck is pleased to contribute the results of our research and development to this worldwide effort to protect women from HIV infection," said Dr. Daria Hazuda, vice president of scientific affairs for infectious disease and HIV at Merck Research Laboratories. "This agreement underscores our long-standing and ongoing commitment to finding new ways to prevent and treat HIV and AIDS."

Collaborating with industry to secure promising compounds is a crucial first step toward making a microbicide accessible to those who most need it. Ensuring access is an essential element of IPM's mission -- and a guiding principle throughout its development process.

To that end, IPM has obtained royalty-free licenses for five antiretroviral compounds from pharmaceutical companies via agreements that have become a model for public-private partnership in fostering global health solutions. These non-exclusive agreements provide IPM flexibility in pursuing development and promoting access, which will allow it to make any resulting microbicide available in developing countries -- including those where the impact of the AIDS pandemic has been most severe.

In addition to Merck, IPM's pharmaceutical partners include Pfizer, which in January 2008 agreed to allow IPM to develop the CCR5 blocker maraviroc as a microbicide. In December 2006, IPM and CONRAD reached independent agreements with Gilead Sciences to develop tenofovir (PMPA), a nucleoside reverse transcriptase inhibitor. In October 2005, IPM entered agreements with Merck and Bristol-Myers Squibb to develop CCR5 blocker and entry inhibitor compounds early in development. In March 2004, IPM signed an agreement with Johnson & Johnson subsidiary Tibotec Pharmaceuticals to develop the company's non-nucleoside reverse transcriptase inhibitor, dapivirine, as a microbicide; IPM expects to put that compound into a Phase III clinical trial late in 2009.

Safe and effective microbicides could provide women in the developing world with a powerful new tool to protect themselves from HIV that would complement existing prevention methods. In the past two years the number of women living with HIV globally has increased by 1 million to 15.4 million. By the end of 2006, women comprised nearly half of the adults living with HIV and AIDS globally, but in sub-Saharan Africa, women and girls already account for almost 61 percent of people living with HIV.

About IPM: The International Partnership for Microbicides was established in 2002 to accelerate the development and accessibility of microbicides to prevent HIV transmission in women. By screening compounds, designing optimal formulations, establishing manufacturing capacity, developing trial sites and conducting clinical trials, IPM works to improve the efficiency of all efforts to develop and deliver safe and effective microbicides as soon as possible. IPM's donors include the governments of Belgium, Canada, Denmark, France, Germany, Ireland, the Netherlands, Norway, Sweden, the United Kingdom and the United States, as well as the European Commission, the Rockefeller and Bill & Melinda Gates Foundations, UNFPA, and the World Bank.

SOURCE International Partnership for Microbicides
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis
2. Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy
3. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
4. Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test
5. GlaxoSmithKline Receives New HHS Order for H5N1 Bulk Antigen. First North American Clinical Trials with GSKs Candidate Pre-pandemic Flu Vaccine to Start.
6. CryoCor Receives FDA Approval for Right Atrial Flutter
7. Ranbaxy Receives Approval to Manufacture and Market Hydrocodone Bitartrate and Acetaminophen Tablets USP
8. Dimericine(R) Receives FDA Fast Track Designation for Treatment Of Photosensitivity in XP Patients
9. Poniard Pharmaceuticals Receives FDA Fast Track Designation for Picoplatin for Treatment of Small Cell Lung Cancer
10. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
11. The Female Health Company Receives USAID DELIVER PROJECT Order for 5 Million Units
Post Your Comments:
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/26/2015)... 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in the ... Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new 247-page ... therapeutic drug monitoring market, including emerging tests, technologies, ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... November 26, 2015 , ... ... (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and public R&D ... Nairobi (UNON) for the opening of the 5th African Network for Drugs and ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an article published November ... more widely heralded as a breakthrough for performing hernia repairs. The article explains that ... surgery is that it can greatly reduce the pain that a patient might otherwise ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 25, 2015, ... for the Narconon network, announced the release of a new cutting edge recovery program ... organization has been working with drug- and alcohol-addicted individuals with the purpose to free ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 23rd 2015 Cozy ... personal heating products business. Cozy Products explains what this means for business moving ... well with the Cozy Products business model: to sell personal heaters that reduce energy ...
(Date:11/25/2015)... ... 2015 , ... Beddit® has launched a new Android app for ... features a more intuitive SleepScoreā„¢ that rates sleep quality on a 100-point scale and ... created by a proprietary algorithm. Beddit analyzes the data to provide an easy to ...
Breaking Medicine News(10 mins):