Navigation Links
Microarray Sequence Capture Speeds Large-Scale Resequencing of Targeted Genomic Regions
Date:10/15/2007

MADISON, Wis., Oct. 15 /PRNewswire/ -- Researchers at Baylor College of Medicine and Roche NimbleGen Inc., a fully integrated part of Roche Applied Science, today have published details of a highly efficient and cost-effective method for capturing targeted regions of the genome via NimbleChip(TM) microarrays in preparation for high-throughput 454 Sequencing(TM). The technology, called "sequence capture," enables fast and accurate enrichment of thousands of selected genomic regions, either contiguous or dispersed, such as segments of chromosomes or all genes or exons. The study, entitled "Direct Selection of Human Genomic Loci by Microarray Hybridization," appears online (ahead of print) in the journal Nature Methods(1).

In light of the success of the current sequence capture technology, Baylor's Human Genome Sequencing Center (HGSC) has signed on as an early access customer to Roche NimbleGen's sequence capture technology. As presented on October 10, 2007, at the J. Craig Venter Institute's Genomes, Medicine, and the Environment (GME) conference, Roche NimbleGen and 454 Life Sciences, working with Dr. Richard Gibbs, professor and Director of the HGSC, will create a whole-genome human exome (all exons) microarray, with the goal of resequencing the entire human exome.

Resequencing of genes or other genomic regions of interest is a key step in detecting mutations associated with various complex human diseases, such as cancer, asthma and heart disease. The predominant method for selection of specific genomic regions for resequencing has primarily relied on PCR (polymerase chain reaction) to enrich for specific DNA fragments. However, PCR is limited in the length of sequence it can amplify, is difficult to scale or multiplex for the enrichment of thousands of fragments, and has limited performance in the repetitive regions typical of complex genomes, such as human. The sequence capture microarray technology bridges the gap between next-generation DNA s
'/>"/>

SOURCE Roche NimbleGen, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Immunicon Will Exhibit CellCapture CTC Mouse/Rat Kit and EasyCount System for Automated Cell Counting at AACR
2. First Controlled Large-Scale Intervention Angiotensin Receptor Blocker (ARB) Trial in a Japanese Population, JIKEI HEART Study Demonstrates Significant Reduction in Blood Pressure and Protection of Organs with Valsartan
3. Medical Journal Publishes First Large-Scale Survey Revealing Experiences of IPF Patients
4. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
5. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
6. Antisense Pharma: Promising Phase IIb Results of Targeted Therapy with AP 12009 in Recurrent Anaplastic Astrocytoma
7. Targeted Genetics Reports Inflammatory Arthritis Clinical Data at European Rheumatology Conference
8. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
9. ApoCells Cancer Predictive Index Helps Oncologists Select the Most Effective Targeted Drug Therapy
10. News from the Battlefield of Metastatic Cancer: Epeius Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G) from the Stone of Chemistry and Physics
11. Data Show SuperGens Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2015)... Calif. , April 30, 2015  Accuray ... it has signed an agreement with MIM Software ... the TomoTherapy ® and CyberKnife ® product ... Accuray and MIM technology. This is Accuray,s second ... the development of the first iPad-based treatment plan ...
(Date:4/30/2015)... , April 30, 2015  Thoratec Corporation (NASDAQ: ... therapies to save, support and restore failing hearts, said ... Merrill Lynch 2015 Healthcare Conference on Thursday, May 14. ... Chief Executive Officer, will provide an update on the ... p.m., Eastern Daylight Time). The presentation will ...
(Date:4/30/2015)... 2015  DURECT Corporation (Nasdaq: DRRX ) announced ...  Total revenues were $4.8 million and net loss was ... 2015 as compared to total revenues of $6.3 million ... months ended March 31, 2014.At March 31, 2015, we ... cash and investments of $34.9 million at December 31, ...
Breaking Medicine Technology:Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3Thoratec Presentation At Bank Of America Merrill Lynch Healthcare Conference To Be Webcast 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 3DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 4DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 5DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 6DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 7DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 8DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 9
... /PRNewswire/ -- Argus Health Systems, Inc., a ... with Walmart to provide expanded network services. This Preferred ... provide the lowest prescription benefit cost to Argus customers. ... customers a more cost-effective pharmacy network alternative. Access to ...
... Sept. 22, 2011 Watson Pharmaceuticals, Inc. (NYSE: ... and Sandoz Inc. have filed suit against Amphastar Pharmaceuticals, ... United States District Court for the District of Massachusetts. ... which Watson has the exclusive right to distribute in ...
Cached Medicine Technology:Argus Announces Retail Network Relationship 2Watson Confirms Amphastar Patent Lawsuit 2Watson Confirms Amphastar Patent Lawsuit 3
(Date:5/3/2015)... (PRWEB) May 03, 2015 Looking ... that will directly impact your career? The Master ... for dynamic leaders in multinational companies and for ... In a changing global landscape, differences in culture, ... relationships. The EMIB program develops the global competence ...
(Date:5/3/2015)... Hanover, MA (PRWEB) May 03, 2015 It is ... 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been ... of Lissa organized this great family-friendly event to honor her loving ... since its inception. , Just having turned 37, Lissa suffered ... Lissa passed away on August 24, 2012. This event is designed ...
(Date:5/2/2015)... Ticket Down has secured additional inventories of ... awaited event today, Saturday, May 2nd at the MGM Grand ... be able to secure tickets for both the actual fight ... fans have wanted for more than five years was finally ... will step inside the ring to fight Manny “Pac-Man” Pacquiao ...
(Date:5/2/2015)... 02, 2015 ProText Kinetic 2 is a ... Final Cut Pro X. ProText Kinetic 2 features 40 ... Final Cut Pro X . Easily create interactive text ... Film Studios' ProText Kinetic 2. , Using ProText Kinetic is ... two ProText Kinetic presets in the FCPX timeline. Playback ...
(Date:5/2/2015)... May 02, 2015 “ Peachtree Audio ... monthly Tech Report, which features the latest and coolest ... expert and special reporter for NewsWatch, conducted the review ... audio equipment. , Music is an important part ... be pampered and given the royal treatment. Peachtree Audio ...
Breaking Medicine News(10 mins):Health News:The Saint Louis University's Master of International Business Is Now Enrolling For Fall 2015 2Health News:Renowned Brain Aneurysm Foundation to Benefit from Arnold, Missouri’s 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2
... Cyberonics, Inc. (Nasdaq: CYBX ) today announced results for the ... , Results for the second quarter of fiscal 2010 compared ... sales of $40.7 million, a 13% increase from $36.0 million; ... the prior year; U.S. and international epilepsy unit sales increased ...
... Don,t ignore foot pain on the dance floor , CHICAGO, ... not entirely true; dancing the night away can take a toll ... foot injuries that can stop the show, as witnessed this season ... , According to the American College of Foot and Ankle Surgeons, ...
... Calif., Nov. 18 IPC The Hospitalist Company (Nasdaq: ... of New London (HINL), based in New London, Connecticut, and ... The acquisition of these two practices marks IPC,s expansion into ... The two practices combined have approximately 55,000 patient encounters annually. ...
... improves exercise capacity in patients with enlarged hearts , ... keep their hearts healthy, new research shows. , The study ... such as diabetes or high blood pressure -- who were ... weekly physical activity for the previous 15 to 25 years. ...
... ... of the game," but players who sustain a series of even small head bumps may be ... ... blows as "part of the game." But players who sustain a series of even small head ...
... Medical Center (BIDMC) neurologists Alvaro Pascual-Leone, MD, PhD, and ... than $1.5 million from the Michael J. Fox Foundation ... improving the quality of life for patients with Parkinson,s ... system that affects one in 100 individuals over age ...
Cached Medicine News:Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 2Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 3Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 4Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 5Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 6Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 7Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 8Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 9Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 10Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 11Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 12Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 13Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 14Health News:Healthy Feet Make the Best Dancing Feet 2Health News:IPC The Hospitalist Company Acquires Two New England Practices 2Health News:Lifelong Exercise Keeps Seniors Young at Heart 2Health News:Throw a Yellow Flag on Football-related Head Injuries, Warns the Harvard Mental Health Letter 2Health News:BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinson's research 2
This aron protects at 0.5 mm Pb equivalency and is 20% lighter than our Standard Back-Aid Apron - yet it contains no lead products that can be harmful to the environment!...
Crisscross shoulder design facilitates better posture and distributes weight to back and hips for greater comfort. Shoulder pads soften shoulder contact with apron for additional comfort....
Use this workhorse apron where 360 of protection from direct and scatter radiation is required....
... Our popular Back-Aid Apron now ... Universal Back-Saver Belt that has ... more weight off your shoulders! ... strap redistribute weight from the ...
Medicine Products: