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MicroRNA First Disclosed by Rosetta Genomics may Increase Efficacy of Imatinib (Gleevec(R)(1)) in Glioblastoma
Date:9/18/2008

line in Biochemical and Biophysical Research Communications, scientists demonstrated that overexpressing miR-451 in-vitro caused inhibition of GBM cell growth. In addition, when combining Imatinib (Gleevec(R)), a targeted therapy manufactured by Novartis and approved treatment of CML and gastrointestinal stromal tumors, with miR-451, a synergistic effect has been shown in inhibiting GBM cell proliferation.

Imatinib (Gleevec(R)) is the first approved drug to directly inhibit a protein known to cause a cancer. Several studies have been, and are currently being conducted, to examine the drug's effectiveness in treating GBM.

About microRNAs

MicroRNAs (miRNAs) are recently discovered, naturally occurring, small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown to have different expression in various pathological conditions. As a result, these differences may provide for a novel diagnostic strategy for many diseases.

About Rosetta Genomics

Rosetta Genomics (Nasdaq: ROSG) is a leader in the field of microRNA. Founded in 2000, the company's integrative research platform combining bioinformatics and state-of-the-art laboratory processes has led to the discovery of hundreds of biologically validated novel human microRNAs. Building on its strong IP position and proprietary platform technologies, Rosetta Genomics is working on the application of these technologies in the development of a full range of microRNA
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SOURCE Rosetta Genomics Ltd
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