Navigation Links
MicroConstants Now Offers Nanoparticle Formulation Services

SALT LAKE CITY, March 8 /PRNewswire/ -- MicroConstants, a GLP-compliant Contract Research Organization (CRO) specializing in bioanalytical and pharmacokinetic analysis, has acquired access to a new nanosizing technology that transforms water insoluble compounds into nanoparticles, making formulation preparation and dosing for toxicology studies easier. In multiple cases, our method has been proven to increase the gastro-intestinal absorption of highly insoluble compounds ensuring maximal oral exposure for toxicology studies.

Many commercially available medications and a large majority of New Chemical Entities (NCEs) produced are poorly soluble. For existing medications, this leads to costly and poorly absorbed medications that are minimally effective. For poorly soluble NCEs, higher doses, poor efficacy results and increased production costs often make them non-commercializable. Nanotechnologies have been proven as a valuable adjunct to the development of new therapeutics. Nanoparticles provide a much larger surface area thereby increasing the dissolution rate resulting in enhanced absorption. Nanosizing your compound elicits improved drug loading, exposure and bioavailability, and faster onset (earlier Tmax).

The patented, proprietary nanosizing process used at MicroConstants does not involve water or mechanical shear, so it is faster and more efficient than aqueous-based technologies. Furthermore, the process typically does not require the addition of excipients, leaving the pure Active Pharmaceutical Ingredient (API) ready for easy dispersion as a convenient suspension formulation. Our cost effective technique provides higher dose loading (50-60%), and is amendable to all routes of extravascular administration. The particle size is reproducible and the process is completely scalable.

If you are working with a difficult formulation or a compound with poor absorption, let MicroConstants transform your compound into nanoparticles. Visit us at booth 221 during the SOT Annual Meeting March 8-10, 2010 in Salt Lake City, Utah to learn more.

About MicroConstants

MicroConstants is a GLP-compliant Contract Research Organization (CRO) dedicated to providing premier quality bioanalytical, drug metabolism, pharmacokinetic, formulation and immunoassay support services to pharmaceutical and biotech companies worldwide. We are the largest bioanalytical LC/MS/MS service provider on the West Coast, and specialize in method development, method validation and sample analysis. For more information about our nanoparticle formulation services, or any of the services offered by MicroConstants, please visit our website at

SOURCE MicroConstants

Back to top



SOURCE MicroConstants
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Slo-Niacin(R) Offers More Than 20 Years of Heart Health Support
2. MedQuist Performance Monitor Offers Transparency, Detailed Reporting and Measurement of Clinical Documentation Metrics
3. International Merchant Advisors, Inc. Offers to Invest in Pharmaceutical Chain
4. Bionorica Offers Tips on Selecting Safe and Effective Natural Remedies for Children
5. Babson Executive Education Offers Bio-Pharma: Mastering the Business of Science
6. Blue Cross and Blue Shield of Illinois Offers Consumer Tips for Safe Disposal of Prescription Drugs
7. AstraZeneca Offers Online Enrollment and Additional Improvements to Patient Assistance Program
8. Inverness Medical Innovations Offers to Acquire Standard Diagnostics
9. Offers Insight Into Two Growing Chinese Pharmaceutical Firms
10. Waismann Method Offers Safe and Alternative Treatment for Dependency to Ambien
11. Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs
Post Your Comments:
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology:
(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
Breaking Medicine News(10 mins):