Navigation Links
MicroConstants Now Offers Nanoparticle Formulation Services

SALT LAKE CITY, March 8 /PRNewswire/ -- MicroConstants, a GLP-compliant Contract Research Organization (CRO) specializing in bioanalytical and pharmacokinetic analysis, has acquired access to a new nanosizing technology that transforms water insoluble compounds into nanoparticles, making formulation preparation and dosing for toxicology studies easier. In multiple cases, our method has been proven to increase the gastro-intestinal absorption of highly insoluble compounds ensuring maximal oral exposure for toxicology studies.

Many commercially available medications and a large majority of New Chemical Entities (NCEs) produced are poorly soluble. For existing medications, this leads to costly and poorly absorbed medications that are minimally effective. For poorly soluble NCEs, higher doses, poor efficacy results and increased production costs often make them non-commercializable. Nanotechnologies have been proven as a valuable adjunct to the development of new therapeutics. Nanoparticles provide a much larger surface area thereby increasing the dissolution rate resulting in enhanced absorption. Nanosizing your compound elicits improved drug loading, exposure and bioavailability, and faster onset (earlier Tmax).

The patented, proprietary nanosizing process used at MicroConstants does not involve water or mechanical shear, so it is faster and more efficient than aqueous-based technologies. Furthermore, the process typically does not require the addition of excipients, leaving the pure Active Pharmaceutical Ingredient (API) ready for easy dispersion as a convenient suspension formulation. Our cost effective technique provides higher dose loading (50-60%), and is amendable to all routes of extravascular administration. The particle size is reproducible and the process is completely scalable.

If you are working with a difficult formulation or a compound with poor absorption, let MicroConstants transform your compound into nanoparticles. Visit us at booth 221 during the SOT Annual Meeting March 8-10, 2010 in Salt Lake City, Utah to learn more.

About MicroConstants

MicroConstants is a GLP-compliant Contract Research Organization (CRO) dedicated to providing premier quality bioanalytical, drug metabolism, pharmacokinetic, formulation and immunoassay support services to pharmaceutical and biotech companies worldwide. We are the largest bioanalytical LC/MS/MS service provider on the West Coast, and specialize in method development, method validation and sample analysis. For more information about our nanoparticle formulation services, or any of the services offered by MicroConstants, please visit our website at

SOURCE MicroConstants

Back to top



SOURCE MicroConstants
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Slo-Niacin(R) Offers More Than 20 Years of Heart Health Support
2. MedQuist Performance Monitor Offers Transparency, Detailed Reporting and Measurement of Clinical Documentation Metrics
3. International Merchant Advisors, Inc. Offers to Invest in Pharmaceutical Chain
4. Bionorica Offers Tips on Selecting Safe and Effective Natural Remedies for Children
5. Babson Executive Education Offers Bio-Pharma: Mastering the Business of Science
6. Blue Cross and Blue Shield of Illinois Offers Consumer Tips for Safe Disposal of Prescription Drugs
7. AstraZeneca Offers Online Enrollment and Additional Improvements to Patient Assistance Program
8. Inverness Medical Innovations Offers to Acquire Standard Diagnostics
9. Offers Insight Into Two Growing Chinese Pharmaceutical Firms
10. Waismann Method Offers Safe and Alternative Treatment for Dependency to Ambien
11. Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs
Post Your Comments:
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 ... the addition of the "2016 Future Horizons ... Monitoring (TDM) Market: Supplier Shares, Country Segment Forecasts, ... offering. --> ... comprehensive analysis of the Japanese therapeutic drug monitoring ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Therapeutic Drug Monitoring ... Forecasts, Competitive Intelligence, Emerging Opportunities"  report ... ) has announced the addition ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... November 27, 2015 , ... ... software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term Support) into ... Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that ...
(Date:11/26/2015)... ... , ... Inevitably when people think Thanksgiving, they also think Holiday sales and ... Friday and Cyber Monday massage chair sales to receive the best pricing ... to find the best massage chair deals, they can see all of the coupons ...
(Date:11/26/2015)... Ashburn, VA (PRWEB) , ... November 26, 2015 ... ... Planners, an American Express Travel Representative. As a franchise owner, Somu now offers ... range of cruise, destination wedding packages, private cruise sales, as well as, cabin ...
(Date:11/26/2015)... ... 26, 2015 , ... Jobs in hospital medical laboratories and in the imaging ... staffing agency Aureus Medical Group . These fields, as well as ... searching for healthcare jobs through the company’s website, , The leading ...
(Date:11/26/2015)... ... 26, 2015 , ... WorldCare International, Inc., the first company ... Employee Benefits Conference. The Employee Benefits Conference was hosted by the International Foundation ... 11th, 2015. The conference was held at the Hawaii Convention Center in Honolulu, ...
Breaking Medicine News(10 mins):