Navigation Links
MicroConstants Now Offers Nanoparticle Formulation Services

SALT LAKE CITY, March 8 /PRNewswire/ -- MicroConstants, a GLP-compliant Contract Research Organization (CRO) specializing in bioanalytical and pharmacokinetic analysis, has acquired access to a new nanosizing technology that transforms water insoluble compounds into nanoparticles, making formulation preparation and dosing for toxicology studies easier. In multiple cases, our method has been proven to increase the gastro-intestinal absorption of highly insoluble compounds ensuring maximal oral exposure for toxicology studies.

Many commercially available medications and a large majority of New Chemical Entities (NCEs) produced are poorly soluble. For existing medications, this leads to costly and poorly absorbed medications that are minimally effective. For poorly soluble NCEs, higher doses, poor efficacy results and increased production costs often make them non-commercializable. Nanotechnologies have been proven as a valuable adjunct to the development of new therapeutics. Nanoparticles provide a much larger surface area thereby increasing the dissolution rate resulting in enhanced absorption. Nanosizing your compound elicits improved drug loading, exposure and bioavailability, and faster onset (earlier Tmax).

The patented, proprietary nanosizing process used at MicroConstants does not involve water or mechanical shear, so it is faster and more efficient than aqueous-based technologies. Furthermore, the process typically does not require the addition of excipients, leaving the pure Active Pharmaceutical Ingredient (API) ready for easy dispersion as a convenient suspension formulation. Our cost effective technique provides higher dose loading (50-60%), and is amendable to all routes of extravascular administration. The particle size is reproducible and the process is completely scalable.

If you are working with a difficult formulation or a compound with poor absorption, let MicroConstants transform your compound into nanoparticles. Visit us at booth 221 during the SOT Annual Meeting March 8-10, 2010 in Salt Lake City, Utah to learn more.

About MicroConstants

MicroConstants is a GLP-compliant Contract Research Organization (CRO) dedicated to providing premier quality bioanalytical, drug metabolism, pharmacokinetic, formulation and immunoassay support services to pharmaceutical and biotech companies worldwide. We are the largest bioanalytical LC/MS/MS service provider on the West Coast, and specialize in method development, method validation and sample analysis. For more information about our nanoparticle formulation services, or any of the services offered by MicroConstants, please visit our website at

SOURCE MicroConstants

Back to top



SOURCE MicroConstants
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Slo-Niacin(R) Offers More Than 20 Years of Heart Health Support
2. MedQuist Performance Monitor Offers Transparency, Detailed Reporting and Measurement of Clinical Documentation Metrics
3. International Merchant Advisors, Inc. Offers to Invest in Pharmaceutical Chain
4. Bionorica Offers Tips on Selecting Safe and Effective Natural Remedies for Children
5. Babson Executive Education Offers Bio-Pharma: Mastering the Business of Science
6. Blue Cross and Blue Shield of Illinois Offers Consumer Tips for Safe Disposal of Prescription Drugs
7. AstraZeneca Offers Online Enrollment and Additional Improvements to Patient Assistance Program
8. Inverness Medical Innovations Offers to Acquire Standard Diagnostics
9. Offers Insight Into Two Growing Chinese Pharmaceutical Firms
10. Waismann Method Offers Safe and Alternative Treatment for Dependency to Ambien
11. Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs
Post Your Comments:
(Date:11/24/2015)... , Nov. 24, 2015  BioPlast Manufacturing, ... the medical research, clinical diagnostic and biotech environments, ... leading manufacturer of quality petri dishes. This acquisition ... clients a platform of products that are designed ... with the highest quality.  ...
(Date:11/24/2015)... brand Revo has debuted a new capsule collection ... Bono as part of the " Buy Vision, Give Sight ... than 5 million people by 2020.  --> ... sale of every pair of Revo sunglasses, including Bono,s "Vision ... to the "Buy Vision, Give Sight" initiative. These funds will ...
(Date:11/24/2015)... USA , Inc. (OTCQB: WCUI), today provided an update ... to targeted dermatology markets in Boston , ... North Carolina . This follows earlier shipments to the ... , and New York dermatology markets. ... reported on October 1, 2015 will be realized in the pending quarter, ...
Breaking Medicine Technology:
(Date:11/24/2015)... VA (PRWEB) , ... November 24, 2015 , ... Preparing ... 1:30 p.m. – 3:00 p.m. EST, , FDA has long asserted ... CLIA regulations apply to performing the tests and do not meet the device regulations. ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... advisory organization, is pleased to welcome Winter-Dent & Company as its newest Partner ... day one to become a client's most trusted advisor regardless of whether that ...
(Date:11/24/2015)... ... November 24, 2015 , ... With Thanksgiving right around the ... safety tips to help protect your family and vehicle. , According to the National ... Thanksgiving holiday weekend. Amica is sharing the following safety tips from the NHTSA: ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Rodney E. Willey , has answered a new ... Center for Sleep Disorders, provides treatment for snoring and sleep apnea through oral ... Koala Center for Sleep Disorders in the US, one of four in the Illinois area. ...
(Date:11/24/2015)... ... 24, 2015 , ... Dr. Kevin Day, local family chiropractor in Warsaw ... this holiday season. During the Indiana winter months, Vitamin D deficiency can lead ... at AlignLife want to help provide the tools needed to combat it this year! ...
Breaking Medicine News(10 mins):