Navigation Links
Michael J. Fox Foundation-Funded Team Pursuing Glutamate-Based Treatment for Parkinson's Disease Hits Major Milestone
Date:9/30/2009

New molecules may be an alternative therapy for Parkinson's

NEW YORK, Sept. 30 /PRNewswire-USNewswire/ -- Michael J. Fox Foundation-funded researchers at Vanderbilt University Medical Center have reached a milestone in the development of potential new drugs for Parkinson's disease that may avoid the limitations of current therapy.

The team, which received an MJFF award of up to $4.4 million under the Foundation's 2007 LEAPS (Linked Efforts to Accelerate Parkinson's Solutions) initiative, has identified two drug-like molecules that, when given systematically in a pre-clinical model of Parkinson's disease, reduce PD symptoms by acting on a specific glutamate receptor in the brain called the metabotropic glutamate receptor, or mGluR4.

Jeffrey Conn, PhD, director of the Vanderbilt Drug Discovery Program and leader of the research team, will detail the discovery in a presentation called "Discovery of mGluR4 Potentiators for Symptomatic and Disease-modifying Treatment of PD" at the third annual Parkinson's Disease Therapeutics Conference, hosted today in New York City by The Michael J. Fox Foundation and The New York Academy of Sciences.

"If we can develop a molecule that has the right properties and does not have toxicity, we really believe this has an opportunity to have a major impact for Parkinson's patients," said Conn. "Nothing could be more exciting than that... Nothing could be more satisfying."

"Obviously there are no guarantees," Dr. Conn cautioned. But if progress continues, clinical trials in patients with Parkinson's disease could begin sometime in 2013, he said.

In previous studies, Conn and others have found that they could relieve symptoms of Parkinson's disease in pre-clinical models by activating the mGluR4 receptor.

In their latest finding, the Vanderbilt researchers have found two compounds that act on mGluR4 and, when given systemically in a pre-clinical model of Parkinson's disease, get to the brain and relieve motor symptoms, including rigidity and akinesia or a "freezing" of certain motor muscles. Further pre-clinical testing will be required before tests in humans can begin. But, said Conn, the identification of these molecules is "a big step forward."

Dr. Conn's colleagues in this effort include Colleen Niswender, PhD, Corey Hopkins, PhD, Carrie Jones, PhD, Craig Lindsley, PhD, and David Weaver, PhD, each of whom directs critical components of this large multidisciplinary effort.

More information, including a detailed Q&A with Jeff Conn, is available on The Michael J. Fox Foundation's Web site at www.michaeljfox.org/research.

The Michael J. Fox Foundation is dedicated to ensuring the development of better treatments, and ultimately a cure, for Parkinson's disease through an aggressively funded research agenda. MJFF has funded $149 million in research to date.

SOURCE Michael J. Fox Foundation


'/>"/>
SOURCE Michael J. Fox Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Michael J. Fox Foundation Commits Up to $12 Million for Targeted Parkinsons Therapeutic Development in 2010
2. Lilly and New York City Mayor Michael R. Bloomberg Announce Lilly Agrees to be First Tenant of East River Science Park; Issue Urgent Call for Healthcare Reform that Protects Innovation and Jobs
3. Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinsons Therapeutic Targets
4. Michael J. Fox Foundation Commits up to $6.5 Million in Funding for Critical Challenges in Parkinsons Disease
5. Michael J. Fox Foundation Awards $2.1 Million to Improve Drug Delivery in Parkinsons Disease
6. Michael J. Fox Foundation Awards $2.9 Million for Two New Parkinsons Disease Clinical Trials
7. Michael J. Fox Foundation Awards $2.7 Million to Four Industry Teams for Pre-Clinical Parkinsons Disease Research
8. Michael J. Fox Foundation Announces $11 Million in 2009 Funding for Translational, Pre-Clinical and Clinical Parkinsons Disease Research
9. Michael J. Fox Foundation Awards $2 Million for Research on Cognitive and Mood Symptoms of Parkinsons Disease
10. Michael J. Fox Foundation Funds $1.1 Million for Cutting-Edge Approaches to Parkinsons Disease Under Rapid Response Innovation Awards 2008
11. Prepared Remarks of Attorney General Michael B. Mukasey Before the House Judiciary Committee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... -- Boston Scientific Corporation (NYSE: BSX ) ... assets and capabilities of the Neovasc, Inc., (NASDAQ: ... as well as a 15% equity stake in Neovasc, ... Neovasc advanced biological tissue business makes elements used in ... System. * Upon completion of the transaction, the ...
(Date:12/2/2016)... , Dec. 2, 2016 Lianluo ... Smart" or "the Company") which develops, markets and ... in China and international ... Disease Diagnosis and Treatment New Progress Forum, co-hosted ... Guangdong Province , Guangdong Provincial People,s ...
(Date:12/2/2016)... 2016 On Thursday, the NASDAQ Composite ... while the Dow Jones Industrial Average managed to stay in ... markets, which prompted Stock-callers this morning to look at the ... NUVA ), Smith & Nephew PLC (NYSE: ... and Cesca Therapeutics Inc. (NASDAQ: KOOL ). You ...
Breaking Medicine Technology:
(Date:12/2/2016)... ... , ... Sourced from the Isbre Springs beneath the 5,000 year old Hardanger ... of just 6 ppm TDS (Total Dissolved Solids) in addition to its excellent taste ... several ShopRite and FoodTown stores in NJ and received rave comments from consumers. , ...
(Date:12/2/2016)... ... December 02, 2016 , ... Clarify Health ... has raised $6.0 million in an initial round of funding. The round was ... and their caregivers can receive far better care through the application of the ...
(Date:12/2/2016)... ... ... ‘Tis the season for giving! Today, 20 creative teams across the nation ... the Drug Enforcement Administration as part of the National Red Ribbon Week Photo Contest. ... decorated their campuses with this year’s Red Ribbon Week theme: “YOLO. Be Drug Free,” ...
(Date:11/30/2016)... ... November 30, 2016 , ... Standard ... 75, an annual ranking and recognition of the largest closely held companies headquartered ... ranked from 2008-2016. In addition, Standard Process was awarded the Talent Award for ...
(Date:11/30/2016)... ... 2016 , ... The Cronovo Smartwatch, the first on the ... at an affordable price, is now available on the crowdfunding website Kickstarter ... changer” when it comes to the smartwatch. , "With Cronovo, we’ve combined the ...
Breaking Medicine News(10 mins):