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Michael J. Fox Foundation-Funded Study Identifies Best Dyskinesia Clinical Rating Scale
Date:5/1/2012

the past few years in both academia and the pharmacological industry to develop drugs to treat this side effect.  We're hopeful that the UDysRS will be a useful tool to help translate research into treatments."  

"We feel that this study will establish one standard scale for the assessment of dyskinesia in Parkinson's disease, allowing one primary measurement tool to be used internationally," added Goetz. 

To date, researchers have used multiple scales to track treatment effect in dyskinesia, employing various methods: Some are based on physician-driven patient interviews, others on patient self-reporting, while others require in-the-clinic observations (UDysRS incorporates all three of these techniques). Prior to this study, there was no real evidence as to which scale provided the most sensitive measure.  It was also unclear if any could provide a useful measurement on the effect of a potential drug. 

In addition to showing UDysRS' superiority, the double-blind, placebo-controlled study established effect size relative to use of amantadine, a drug that was originally approved to treat a certain type of influenza and that has been deemed efficacious for dyskinesia by the Movement Disorder Society.  But this conclusion was based on small-scale studies; more research is needed to better understand its therapeutic benefit on dyskinesia.  The reality is, amantadine works only for some patients and for a limited time. This study establishes a minimum benchmark by which to measure potential therapies moving forward – new drugs would hope to show better efficacy than amantadine.

Study results are being presented at this June's International Congress of Parkinson's Disease and Movement Disorders in Dublin, Ireland.  To learn more about the study's findings, read the Foundation's News in Context interview with Dr. Stebbins and Scientific Advisory Board member David Weiner, M.D. at

SOURCE The Michael J. Fox Foundation
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