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Micell Technologies Announces Positive Preliminary Data from DESSOLVE I Study of MiStent® Sirolimus Drug Eluting Coronary Stent System
Date:11/8/2011

imary efficacy endpoint was in-stent late lumen loss. Safety was assessed by incidence of major adverse cardiac events (MACE) and presence of strut coverage with tissue within the treated artery at each time point. William Wijns, M.D., Cardiovascular Center, Aalst, Belgium and John Ormiston, M.D., Mercy Angiography Unit, Auckland, NZ are co-principal investigators for this trial.

The DESSOLVE II CE Mark trial is a multi-center study of patients with documented stable or unstable angina pectoris. The primary endpoint is superiority of the MiStent DES in minimizing in-stent late lumen loss at nine months, compared to Medtronic's Endeavor® Sprint DES, as measured by the angiography core laboratory in de novo coronary lesions in vessels ranging in diameter from 2.5 to 3.5 mm and amenable to treatment with a maximum 30 mm length stent.  The DESSOLVE II study completed enrollment of 183 patients in July 2011.

About the MiStent DES

The MiStent Sirolimus-Eluting Coronary Stent System is designed to optimize healing in patients with coronary artery disease. Micell's rapid-absorbing drug/polymer coating is intended to precisely and consistently control drug elution and polymer exposure duration to reduce the safety risks associated with current commercially available drug-eluting stent technologies.

The MiStent DES innovative stent system includes a proprietary stent coating that contains crystalline drug (sirolimus) and an absorbable polymer. As the polymer softens and disperses from the stent into the adjacent tissue, the coating provides controlled and sustained release of therapeutic levels of drug within the surrounding tissue. Results of animal studies have determined that the drug/polymer coating is cleared from the stent in 45 to 60 days leaving a bare metal stent and the polymer is completely absorbed into the surrounding tissue in 90 days to promote long-term patency and compatibility with the artery.'/>"/>

SOURCE Micell Technologies, Inc.
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