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Micell Technologies Announces Positive Preliminary Data from DESSOLVE I Study of MiStent® Sirolimus Drug Eluting Coronary Stent System
Date:11/8/2011

DURHAM, N.C., Nov. 8, 2011 /PRNewswire/ -- Micell Technologies, Inc. today announced the release of preliminary data from the first-in-human clinical study of the MiStent® Sirolimus Drug Eluting Coronary Stent System (MiStent DES), a thin-strut drug-eluting stent distinguished by a rapid-absorbing drug/polymer coating designed for controlled drug release. Four, six and eight month data from the DESSOLVE I trial were presented at the Transcatheter Cardiovascular Therapeutics Conference (TCT 2011) by John Ormiston, M.D., Mercy Angiography Unit, Auckland, New Zealand, a principal investigator in the study. TCT will make the presentation available on its website at www.tctmd.com following the conference.

"These preliminary study results demonstrated excellent performance by the MiStent DES at up to eight months post-procedure -- when patients typically experience the greatest increase in neointimal hyperplasia," said Dr. Ormiston. "MiStent DES is intended to provide enhanced patient safety and outcome by eliminating long-term exposure to DES non-erodible polymers. In addition to delivering clinical performance, MiStent DES may also enable physicians to pursue shorter duration dual anti-platelet therapy, and offer a safer choice to their non-compliant patients or patients who may be undergoing additional surgical procedures."  

Thirty patients were treated with the MiStent DES with independent subgroups of 10 patients assigned to a four month, six month or eight month follow-up. The primary efficacy endpoint was in-stent late lumen loss (LLL). Safety was assessed by incidence of major adverse cardiac events (MACE) and presence of tissue coverage within the treated artery at each time point. Angiography, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging results were measured by independent core laboratories. Preliminary analysis of the data demonstrated a very low median
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