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Mezzion Pharma Announces Collaboration With New England Research Institutes To Evaluate Udenafil In Adolescents With Single Ventricle Heart Defects
Date:1/10/2014

SEOUL, Korea, Jan. 10, 2014 /PRNewswire/ -- Mezzion Pharma Co. Ltd., announced that it has signed an agreement with New England Research Institutes, Inc., who are authorized by the National Heart, Lung, and Blood Institute-supported Pediatric Heart Network (PHN) to manage and conduct clinical trials on its behalf. The clinical studies to be conducted under this agreement were developed by a subcommittee made up of representatives of the PHN.  The studies will be funded by a grant from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.

The studies, which will be led by PHN researchers will assess the improvement in certain acute and chronic symptoms in adolescents who had the Fontan procedure earlier in life.

The Fontan operation is the final surgery in the strategy of staged palliation for children born with congenital heart defects resulting in functional single-ventricle physiology. Fontan patients have a significantly shortened life span, often not surviving past the third or fourth decade of life, mainly due to deteriorating ventricular performance and increasing pulmonary vascular resistance.   

PDE5 inhibitors have demonstrated utility in reducing pulmonary vascular resistance and improving ventricular performance in other types of patients.  Those characteristics make PDE5 inhibitors, especially a long acting compound such as udenafil, an attractive potential therapy for the Fontan population in which cardiac output is limited by the absence of a sub-pulmonary ventricle.  A medication capable of allowing for more efficient transit of blood through the pulmonary vascular bed could allow for improvement in cardiac preload, and therefore improved cardiac output for any given level of systemic venous pressure.

Mezzion Pharma will file an Investigational New Drug Application (IND) with the
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SOURCE Mezzion Pharma Co. Ltd.
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