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Metabolic Solutions Development Company to Present Recent Findings on the Therapeutic Potential of Increasing Brown Fat in the Treatment of Diabetes at Annual American Diabetes Association Conference
Date:6/21/2011

agents."

Colca's presentation, along with four others by MSDC and its collaborating partners at this year's ADA conference, will further elucidate MSDC's novel target and the pathways through which the company's Phase 2 drug candidates are acting. The presentations also will provide new insights into insulin re-sensitization and other potential metabolic benefits of a novel class of insulin sensitizers which could play a pivotal role in the development of new diabetes treatments.

"The definition of a new path forward is urgently needed to produce novel therapeutics to adequately treat, and eventually prevent, diabetes," said Colca.  "Through these presentations, we will begin to disclose how the novel mechanism of action of our compounds connects with pathways that are known to be dysregulated in diabetes."

On Sunday, June 26, MSDC Senior Research Scientist William G. McDonald's poster presentation, "Novel Insulin Sensitizers Enhance Brown Adipose Cell Differentiation by Modulation of Wnt Signaling Pathway," will take place at noon in Hall B. Disruptions in the Wnt signaling pathway are known to predispose persons to type 2 diabetes.

MSDC collaborative presentations include:

  • June 25 at 11:30 a.m. PT, "A Mitochondrial Target of Pioglitazone Acutely Regulates Mitochondrial Respiratory Function." The presentation will be held in Hall B. This work from Dr. Anne Murphy's laboratory at the University of California at San Diego will show how a novel mitochondrial target is involved in the direct effect of insulin sensitizers on metabolism.

  • June 25 at 12:30 p.m. PT, "Activating AMPK and Downregulating mTOR with a PPAR-g Sparing TZD Decreases Insulin Resistance & Mediates Human Beta-Cell Rest & Restoration of Insulin Content." The presentation from Dr. Mike McDaniel's laboratory at Washington University in St. Louis demonstrates the potentia
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SOURCE Metabolic Solutions Development Company
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