Navigation Links
Metabolic Solutions Development Company to Present Recent Findings on the Therapeutic Potential of Increasing Brown Fat in the Treatment of Diabetes at Annual American Diabetes Association Conference

KALAMAZOO, Mich., June 21, 2011 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC) and collaborators will present their research providing insights into the therapeutic potential of increasing brown adipose tissue in the treatment of diabetes and the unique mechanism of action of the company's novel insulin sensitizers that connects with pathways known to be dysregulated in diabetes at the American Diabetes Association's (ADA) 71st annual Scientific Sessions conference in San Diego, Calif., June 24-28, 2011. The ADA conference is the world's leading scientific and medical meeting focused on diabetes.  All sessions at the ADA will be held in the San Diego Convention Center.

MSDC Chief Scientific Officer Jerry Colca, Ph.D., will present "Enhancement of Brown Adipose Tissue Development In Vivo by a Novel Insulin Sensitizer" on Saturday, June 25 at 1:45 p.m. PT in Room 29. The presentation will conclude a symposium involving influential thought leaders in the field that focuses on cutting-edge concepts in brown and white adipocyte biology, an emerging important factor in the etiology of diabetes.  A key theme of this session will be the therapeutic potential of increasing brown adipose tissue in the treatment of diabetes. The MSDC presentation will suggest that this is possible with the company's small molecule compounds that are currently in clinical trials.

"The breakthrough insights MSDC's researchers and collaborators will present at this year's ADA meeting support our view that MSDC's novel insulin sensitizing drugs can treat the root causes of type 2 diabetes and free patients from the adverse side effects of current treatments," said MSDC CEO Stephen Benoit.

"We believe these insights are directly related to the success we've observed with MSDC-0160 in Phase 2 clinical trials regarding control of fasting blood glucose without the weight gain and edema associated with the currently marketed insulin sensitizing agents."

Colca's presentation, along with four others by MSDC and its collaborating partners at this year's ADA conference, will further elucidate MSDC's novel target and the pathways through which the company's Phase 2 drug candidates are acting. The presentations also will provide new insights into insulin re-sensitization and other potential metabolic benefits of a novel class of insulin sensitizers which could play a pivotal role in the development of new diabetes treatments.

"The definition of a new path forward is urgently needed to produce novel therapeutics to adequately treat, and eventually prevent, diabetes," said Colca.  "Through these presentations, we will begin to disclose how the novel mechanism of action of our compounds connects with pathways that are known to be dysregulated in diabetes."

On Sunday, June 26, MSDC Senior Research Scientist William G. McDonald's poster presentation, "Novel Insulin Sensitizers Enhance Brown Adipose Cell Differentiation by Modulation of Wnt Signaling Pathway," will take place at noon in Hall B. Disruptions in the Wnt signaling pathway are known to predispose persons to type 2 diabetes.

MSDC collaborative presentations include:

  • June 25 at 11:30 a.m. PT, "A Mitochondrial Target of Pioglitazone Acutely Regulates Mitochondrial Respiratory Function." The presentation will be held in Hall B. This work from Dr. Anne Murphy's laboratory at the University of California at San Diego will show how a novel mitochondrial target is involved in the direct effect of insulin sensitizers on metabolism.

  • June 25 at 12:30 p.m. PT, "Activating AMPK and Downregulating mTOR with a PPAR-g Sparing TZD Decreases Insulin Resistance & Mediates Human Beta-Cell Rest & Restoration of Insulin Content." The presentation from Dr. Mike McDaniel's laboratory at Washington University in St. Louis demonstrates the potential for this mechanism of action to produce positive effects directly on human insulin-secreting pancreatic beta-cells.

  • June 27 at 1 p.m. PT, "Insulin Resistance in ob/ob Mice Is Ameliorated by Thiazolidinediones That Do Not Activate PPARg."  This presentation from the laboratory of Dr. Brian Finck at Washington University in St. Louis provides a detailed comparison of the clinical candidate in mouse models of diabetes with insight into the mechanism of action.

MSDC has two novel insulin sensitizers in clinical trials for the treatment of type 2 diabetes. Phase 2a clinical data from the company's lead candidate, MSDC-0160, demonstrated that it improved insulin sensitivity and lowered blood glucose levels in humans without the side effects of the current market leading diabetes medicines. The compound also demonstrated significant improvements in other important metabolic disease parameters, including blood pressure and lipids. A phase 2b study of MSDC-0160 is currently under way in patients with type 2 diabetes and data are expected to be available in January 2012.

A Phase 2a trial of MSDC-0602, the company's second drug candidate for the treatment of type 2 diabetes is currently under way.  Results of this study are expected to be available in September 2011.  A Phase 2b study of MSDC-0602 is targeted to begin in the first quarter of 2012.

About Metabolic Solutions Development Company:

Metabolic Solutions Development Company ( is a drug discovery and development company exploiting novel molecular targets to develop new therapies for metabolic diseases associated with altered mitochondrial function, especially insulin resistance and type 2 diabetes. The company has raised nearly $50 million in support of the development of its pioneer and lead products, MSDC-0160 (currently in Phase 2b) and MSDC-0602 (currently in Phase 2a), which are novel insulin sensitizers that selectively modulate mitochondrial control of certain metabolic-signaling and nutrient-sensing pathways resulting in improved insulin action without fluid retention or weight gain.  Founded in 2006 by former Pfizer researchers Jerry Colca, Ph.D. and Rolf Kletzien, Ph.D., MSDC is headquartered in Kalamazoo, Michigan.    

Tyler Lecceadone

SOURCE Metabolic Solutions Development Company
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. GT Life Sciences Broadens Intellectual Property Portfolio with Issuance of U.S. Patent on Core Computational Systems and Methods for Genomic-based Metabolic Modeling
2. Creating a Road Map for Successful Metabolic New Product Launches
3. Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting
4. Metabolic Solutions Development Company Launches Phase 2a Trial of Its Second Compound to Treat Type 2 Diabetes
5. Dave Anderson and William Thomsen Join SRI Internationals Center for Advanced Drug Research to Lead Programs in Proteomics and Metabolic Disease Drug Discovery
6. Bionovo Announces Publication Describing How Metabolic Adaptability Contributes to the Metastasis of Tumors
7. Metabolic Status Before Pregnancy Predicts Subsequent Gestational Diabetes
8. Metabolic Solutions Development Company to Present Research Findings to European Association for the Study of Diabetes
9. Windhover Information Names D-Tagatose One of Top 10 Most Promising CV/Metabolic Drugs in Development
10. Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity From Its Broad Metabolic Disease Franchise at ADA Scientific Sessions
11. Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence
Post Your Comments:
(Date:10/9/2015)... CHAPEL HILL, N.C. , Oct. 9, 2015 ... Pharmaceutical or Medical Device environments, corporate communications is ... external communications, corporations and professionals must continuously adjust ... the effectiveness of these adjustments is difficult, but ... to today,s communication options. ...
(Date:10/9/2015)... N.J. , and CINCINNATI , ... (CFI) will hold two Design Thinking labs with Konica ... is collaborating with CFI to utilize Design Thinking to ... strategy for the future using a visual roadmap that ... --> --> Primary Imaging is the ...
(Date:10/9/2015)... 9, 2015 ® ... einer Kolonoskopie im Rahmen eines Screenings, einer ... NOCT-Studie bewertete auch die Compliance, Sicherheit, Patientenakzeptanz ... ® ) an erwachsenen Patienten vergleicht, die ... einer beobachtenden oder einer diagnostischen Kolonoskopie unterziehen. ...
Breaking Medicine Technology:
... --,Wyeth Pharmaceuticals, a division of Wyeth , provides ... both hormone therapy arms of the,Women's Health Initiative ... American Medical Association. The pooled analysis,showed no apparent ... hormone therapy close to menopause. , The publication ...
... ROCKVILLE, Md., April 4, 2007 -- CytImmune, ... and,commercialization of multifunctional, tumor-targeted therapies has,been selected to ... of Clinical Oncology Annual Meeting in Chicago Illinois,June ... 8:00 am to 12,noon on June 3. Dr. ...
Cached Medicine Technology:
(Date:10/9/2015)... ... ... A new health tool that helps identify if a sore throat is serious, ... just in time for the cold and flu season, which the Center for Disease ... U.S., the real start of cold/flu season is the start of the school year, ...
(Date:10/9/2015)... ... October 09, 2015 , ... Smoke alarms can save lives. In fact, ... risk of dying in reported home fires in half. As part of Fire Prevention ... are property installed and maintained. , Half of home fire deaths result from fires ...
(Date:10/9/2015)... Huntington Beach, CA (PRWEB) , ... October 09, ... ... Rassouli, is now offering a special promotion on Invisalign, the orthodontic system that ... many reasons. The aligners are almost invisible against the teeth, which allow patients ...
(Date:10/9/2015)... ... October 09, 2015 , ... Matrix IT ... product specifications for TRACTUS, the world’s first sterile field scanner. , ... response to the FDA’s recent Unique Device Identifier (UDI) Final Rule, which will ...
(Date:10/9/2015)... Washington, DC (PRWEB) , ... October 09, 2015 , ... ... agreement from the US Centers for Disease Control and Prevention (CDC) to improve the ... 14 years that AAFA has been awarded a project by the CDC and allows ...
Breaking Medicine News(10 mins):
... Network of America, LLC (DNoA) announced today the completion ... Blue Cross Blue Shield of Michigan (BCBSM), a nonprofit ... in Michigan, in addition to members of Michigan-headquartered groups ... , The acquisition brings two strategically focused companies -- ...
... BCBSM Customers Expanded National Dental Network; Solidify BCBSM Position as ... July 1 Blue Cross Blue Shield of Michigan announced ... acquired by Dental Network of America, LLC (DNoA), a strategic ... and DNoA -- will provide BCBSM with a more competitive ...
... , WASHINGTON, July 1 Today,s 65 year old Medicare ... or ,donut hole, is eliminated, says a new analysis of ... Avalere Health. The firm also concludes that although fewer ... by 2020 some of the sickest Medicare beneficiaries will spend ...
... 1 At a bargaining session yesterday with SEIU ... at Kaiser Permanente facilities in California and the rest ... ended when the contractor refused to restore the affordable ... the year. Bargaining broke down Tuesday evening as ...
... the 2009 pistachio harvest little more than two months away, ... with production expected to exceed 2008 levels. Growing conditions have ... of nutrient-rich pistachios to meet increasing demand. , ... September and is estimated at more than 425 million pounds ...
... , WESTCHESTER, Ill., July 1 The Pediatric Brain Tumor ... Fund) and BrainLAB teamed up again this year for the ... in New York City. The June 6 event raised funds ... childhood brain tumors. , , (Photo: ...
Cached Medicine News:
... Tri-Flo® suction catheter design was created ... patients while still providing high suctioning ... (5/6, 8 or 10 Fr) feature ... catheter placement. Our complete catheter line ...
Tracheal Suction Latex Rubber Catheters - Funnel End...
Rubber bronchial coude catheter, X-ray opaque, one eye, whistle tip....
KCIs KinAir IV combines Advanced Pressure Relief Therapy with a manual wound care turn to provide optimum skin care and patient,positioning....
Medicine Products: