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Metabolic Solutions Development Company presents Phase 2a clinical trial results at the 14th International Conference on Alzheimer's Drug Discovery
Date:9/9/2013

KALAMAZOO, Mich., Sept. 9, 2013 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) has announced that Jerry Colca, PhD, co-founder and chief scientific officer of MSDC, will present results of a Phase 2a study on September 9 at the 14th International Conference on Alzheimer's Drug Discovery. In people with dementia due to Alzheimer's disease (AD) who were not diabetic, the study found that the mTOT™-modulating insulin sensitizer (MSDC-0160) maintained glucose metabolism in key regions of the brain associated with cognitive decline due to AD, as confirmed by FDG-PET imaging.

(Photo: http://photos.prnewswire.com/prnh/20130909/CG75830-INFO )

Glucose is a major energy source for cells, and alterations in glucose metabolism by nerve cells (neurons) in the brain have been associated with AD pathology.[1],[2]  Moreover, reduced brain glucose metabolism is region specific.[3],[4],[5]  In this study, in participants treated with placebo, the measure of glucose uptake significantly declined in key regions of the brain associated with cognitive decline in persons with dementia due to Alzheimer's disease; however,  this did not occur in the subjects treated with MSDC-0160.

"We are in urgent need of new approaches in Alzheimer's drug research because there are currently no approved therapies to halt or even slow progression of the disease," said Howard Fillit, MD, Executive Director and Chief Science Officer of the Alzheimer's Drug Discovery Foundation. "The mitochondrially-targeted insulin sensitizers are an exciting new class of drugs in Alzheimer's disease. The current results provide the basis for further clinical investigation of MSDC-0160 in Alzheimer's patients."

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SOURCE Metabolic Solutions Development Company, LLC
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