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Metabolic Solutions Development Company announces publication of Phase 2b data in Clinical Pharmacology & Therapeutics
Date:1/24/2013

c officer. "This prototype and its successor MSDC-0602 represent the next generation of insulin sensitizers."

MSDC's novel insulin sensitizing agents selectively modulate mTOT, a protein complex located in the inner mitochondrial that appears to coordinate carbohydrate, lipid, and amino acid metabolism. This new drug target may also play a role in other diseases of aging such as Alzheimer's disease and Parkinson's disease, as well certain genetic diseases such as polycystic kidney disease.

Phase 2 Clinical Results Support New Target Hypothesis

The publication supports MSDC researchers' long-held hypothesis that lowering of plasma glucose can be achieved without having to activate a nuclear receptor called PPARg, thus providing a new way forward for insulin sensitizers without the side effects that have prevented the development of new drugs. Previously, it was believed that both the activity and the side effects of the only approved class of drugs used to treat insulin resistance -- the core problem for persons diagnosed with type 2 diabetes -- were mediated through PPARg. These studies provide a fresh approach and a new target for new drugs to treat diabetes.

About the MSDC-0160 Phase 2b Study

This study was a 90-day, randomized, double-blind, comparator- and placebo-controlled, multi-dose study completed in 258 patients with type 2 diabetes. The study compared three doses of MSDC-0160 (50 mg, 100 mg and 150 mg) to maximum dose Actos (pioglitazone 45 mg) or placebo taken orally once daily for 12 weeks. All treatments were well tolerated. There were no serious adverse events attributed by investigators to the MSDC drug.

Key top-line data from this study include the following:

  • Both 100 mg/day and 150 mg/day of MSDC-0160 significantly lowered fasting plasma glucose (primary study endpoint).
  • Both 100 mg/day and 150 mg/day of MSDC-0160 lowered hemoglobin A1c similar to 45 mg/
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SOURCE Metabolic Solutions Development Company, LLC
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