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Metabolic Solutions Development Company announces publication of Phase 2b data in Clinical Pharmacology & Therapeutics
Date:1/24/2013

KALAMAZOO, Mich., Jan. 24, 2013 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) announced today the publication of data from a Phase 2b study of the company's prototype insulin sensitizer in patients diagnosed with type 2 diabetes. The data demonstrate MSDC-0160, a novel once-a-day oral insulin sensitizer and the first in a new class of therapeutic agents called mTOT Modulators™, met the study's primary endpoint of significantly reducing fasting plasma glucose (FPG) and significantly reduced hemoglobin A1c (HbA1c).

Of particular importance, the data showed that changes in body weight, hemoglobin, and an important biomarker associated with the production of white fat were significantly less in type 2 diabetic patients treated with MSDC-0160 than in patients treated with a comparator drug, pioglitazone 45 mg, a PPARg agonist. The mTOT paper is available online and is expected to be published in the print edition shortly.

The research was led by MSDC co-founder Jerry Colca , PhD, who was among the original researchers in the field of insulin sensitizers, and who selected and led the early development of Actos (pioglitazone). Dr. Colca's career-long study of the endocrine control of metabolism is the basis for MSDC's research and development of novel compounds that may treat the root causes of diabetes, insulin resistance and defects in pancreatic beta cell function.  The research has led to the discovery of a new target for insulin sensitizers.

"This data confirms our hypothesis that insulin sensitization by mTOT modulators can produce the same lowering of glucose as drugs like pioglitazone, but without the side effects caused by PPARg agonists," said Jerry Colca , PhD, president and chief scientifi
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SOURCE Metabolic Solutions Development Company, LLC
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