Navigation Links
Metabolic Solutions Development Company Reports Positive Top-Line Results From Phase 2a Study of Its Second Compound to Treat Type 2 Diabetes
Date:9/8/2011

n. Additionally, the compound's PPAR-independent pharmacology has not produced the side effects associated with activation of PPARγ.

Insulin sensitizing compounds exert important metabolic effects on mitochondrial metabolism that invoke a molecular switch that controls important cellular processes including sensitivity to insulin. MSDC has identified a novel molecular target through which its two lead insulin sensitizers, MSDC-0602 and MSDC-0160, work to treat type 2 diabetes. The compounds selectively modulate mitochondrial control of certain metabolic-signaling and nutrient-sensing pathways resulting in improved insulin action and generation of brown adipose tissue without fluid retention or weight gain.  

EASD Oral Presentation

There is an expectation there will be weight control over longer treatments with MSDC-0602 given the "browning" of adipose stores. Several recent studies(2,3) have shown that brown adipose tissue or BAT exists in some adult humans. BAT is brown in color because it has a high concentration of mitochondria. Unlike white adipose tissue, BAT is designed to burn rather than store fat. The amount of brown fat is inversely proportioned to body weight (and white adipose tissue). MSDC compounds favor the development of brown fat in animal models and human cells in tissue culture.

MSDC will present study results on the impact of its insulin sensitizing agents on the browning of progenitor cells from the axillary fat pad in a PPAR-independent manner at the upcoming 47th European Association for the Study of Diabetes Annual Meeting in Lisbon, Portugal on Monday, September 12 - 16, 2011:

'/>"/>

SOURCE Metabolic Solutions Development Company, LLC
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Regulus Therapeutics to Present New Advancements in microRNA Therapeutics for Treatment of Metabolic Diseases and Cancer
2. Study Uncovers Key Success Factors and Common Failure Points for Launching New Metabolic Products in Todays Competitive Healthcare Market
3. BioRestorative Therapies Signs License Agreement With University of Utah to Obtain Adipose (Fat) Tissue for its ThermoStem Program to Treat Obesity and Metabolic Disorders
4. Metabolic Solutions Development Company to Present Recent Findings on the Therapeutic Potential of Increasing Brown Fat in the Treatment of Diabetes at Annual American Diabetes Association Conference
5. GT Life Sciences Broadens Intellectual Property Portfolio with Issuance of U.S. Patent on Core Computational Systems and Methods for Genomic-based Metabolic Modeling
6. Creating a Road Map for Successful Metabolic New Product Launches
7. Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting
8. Metabolic Solutions Development Company Launches Phase 2a Trial of Its Second Compound to Treat Type 2 Diabetes
9. Dave Anderson and William Thomsen Join SRI Internationals Center for Advanced Drug Research to Lead Programs in Proteomics and Metabolic Disease Drug Discovery
10. Bionovo Announces Publication Describing How Metabolic Adaptability Contributes to the Metastasis of Tumors
11. Metabolic Status Before Pregnancy Predicts Subsequent Gestational Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ... the patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded ... the notice it received on May 21, 2015 from ... Company was below certain of the Exchange,s continued listing ... of the NYSE MKT Company Guide, due to the ...
(Date:7/30/2015)... , July 30, 2015 Eisai Inc. announced ... the United States , European Union and ... and MHLW, respectively) for eribulin, for the treatment of ... received prior chemotherapy for advanced or metastatic disease. ... from a pivotal global Phase 3 clinical trial (Study ...
(Date:7/30/2015)... COTTAGE, New York , July 30, 2015 /PRNewswire/ ... release of its latest report titled, "Continuous Glucose Monitoring ... - 2020". According to the report, the global continuous ... Mn in 2014 and is expected to reach US$ ... during the forecast period, 2015 to 2020. ...
Breaking Medicine Technology:TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4
... Pa., Jan. 17, 2012 Governor Tom Corbett today visited ... County, where he praised the company for its continued commitment ... 150 high-paying jobs. "Here in Pennsylvania we ... to opportunity. And today we are cutting the ribbon on ...
... Medical Technologies announced today that the Company has started ... an advanced solution that biopsies peripheral Solitary Pulmonary Nodules ... The SPiN Drive system design may ... to never lose or remove navigation at the time ...
Cached Medicine Technology:Veran Medical Technologies Announces Initial Shipment of SPiN DriveĀ® Platform to Customers 2
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, Sigma ... the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key ... meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... new store run by GoodThreads. The store can be accessed by visiting ... many of which are customizable. The best part: whenever a product is purchased, ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... communicate. Rally Insurance Group, Inc. has re-branded their social media profiles to better ... personal way for consumers to communicate, find information, share insights and opinions. The ...
(Date:7/31/2015)... CA (PRWEB) , ... July 31, 2015 , ... According ... and cosmetic experts gathered to see if they could reach a consensus on the ... breast augmentation and facelifts. Overall, the group reached 90 percent consensus on a series ...
(Date:7/31/2015)... ... July 31, 2015 , ... The ... to patients and family members, medical professionals, and researchers, covering a variety of ... conference is a collaborative effort between the Mesothelioma Applied Research Foundation and Memorial ...
Breaking Medicine News(10 mins):Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:New York Area Mesothelioma Specialists to Present at Conference 2Health News:New York Area Mesothelioma Specialists to Present at Conference 3
... This release is available in French . , ... Research Institute of the MUHC at the Montreal Childrens Hospital, ... from 2,000 autism patients and their families over the next ... a coordinated effort to create a database of genetic and ...
... BIRMINGHAM, Ala., May 7 Emageon Inc. (Nasdaq:,EMAG), a ... networks and imaging facilities, will hold its,quarterly conference call ... 12, 2008 at 10:00 AM Eastern Time. The company ... release before the NASDAQ,stock market opens on May 12, ...
... Teams to help People Take off ... it Your Challenge, CHICAGO, May 7 "Give up ... just begun! Founded by Dr. Ian Smith and,backed by leaders ... off its second year having already,inspired almost half a million ...
... /Xinhua-PRNewswire-FirstCall/ -- Linkwell,Corporation (Linkwell) (OTC Bulletin Board: ... healthcare related disinfectants in China,announced today that ... Company, Ltd., (LiKang Disinfectant) began training,and licensing ... The project,is sponsored by and under the ...
... society that hails monogamy as,the tried and true form ... is a large group of people who practice polyamory, ... a time. Others,are aware of and curious about this ... to find information or how to look into the,possibilities. ...
... over 65 could cut expected 50% increase in cases in ... A new clinical guideline on screening for osteoporosis in men ... which notes that osteoporosis rates among men are expected to ... fractures in men result in substantial disease, death and health ...
Cached Medicine News:Health News:The Montreal Children's Hospital of the MUHC begins search for causes of autism 2Health News:Emageon Inc. to Host First Quarter 2008 Financial Results Conference Call May 12, 2008 2Health News:The Challenge Kicks off 2nd Year - Tops 2 Million Pounds Lost, Half a Million Gain Healthier Lives 2Health News:The Challenge Kicks off 2nd Year - Tops 2 Million Pounds Lost, Half a Million Gain Healthier Lives 3Health News:The Challenge Kicks off 2nd Year - Tops 2 Million Pounds Lost, Half a Million Gain Healthier Lives 4Health News:Linkwell Corporation Begins Training and Licensing Beijing Olympics Disinfection Teams 2Health News:Linkwell Corporation Begins Training and Licensing Beijing Olympics Disinfection Teams 3Health News:Linkwell Corporation Begins Training and Licensing Beijing Olympics Disinfection Teams 4Health News:'The Polyamory Handbook': New Guide Covers Entire Spectrum of Rapidly Growing Relationship Style 2Health News:Docs Issue Guideline on Screening for Osteoporosis in Men 2
The focus of HandEchart Professional is to offer a practical and basic electronic patient record keeping system that anyone can learn in minutes....
Archimedes is an innovative specialty calculator. Forget having to remember complicated formulas, just enter the values and out come the results....
A handy, quick reference for physicians, nurses, and other health care providers treating cancer patients....
A handy quick-reference tool for busy residents and clinicians with key facts and points essential for day-to-day patient care....
Medicine Products: