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Metabolic Solutions Development Company Reports Positive Top-Line Results From Phase 2a Study of Its Second Compound to Treat Type 2 Diabetes
Date:9/8/2011

n. Additionally, the compound's PPAR-independent pharmacology has not produced the side effects associated with activation of PPARγ.

Insulin sensitizing compounds exert important metabolic effects on mitochondrial metabolism that invoke a molecular switch that controls important cellular processes including sensitivity to insulin. MSDC has identified a novel molecular target through which its two lead insulin sensitizers, MSDC-0602 and MSDC-0160, work to treat type 2 diabetes. The compounds selectively modulate mitochondrial control of certain metabolic-signaling and nutrient-sensing pathways resulting in improved insulin action and generation of brown adipose tissue without fluid retention or weight gain.  

EASD Oral Presentation

There is an expectation there will be weight control over longer treatments with MSDC-0602 given the "browning" of adipose stores. Several recent studies(2,3) have shown that brown adipose tissue or BAT exists in some adult humans. BAT is brown in color because it has a high concentration of mitochondria. Unlike white adipose tissue, BAT is designed to burn rather than store fat. The amount of brown fat is inversely proportioned to body weight (and white adipose tissue). MSDC compounds favor the development of brown fat in animal models and human cells in tissue culture.

MSDC will present study results on the impact of its insulin sensitizing agents on the browning of progenitor cells from the axillary fat pad in a PPAR-independent manner at the upcoming 47th European Association for the Study of Diabetes Annual Meeting in Lisbon, Portugal on Monday, September 12 - 16, 2011:

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SOURCE Metabolic Solutions Development Company, LLC
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