Navigation Links
Metabolic Solutions Development Company Reports Positive Top-Line Results From Phase 2a Study of Its Second Compound to Treat Type 2 Diabetes
Date:9/8/2011

KALAMAZOO, Mich., Sept. 8, 2011 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) confirmed today the potential of MSDC-0602 to achieve significant glucose control in type 2 diabetes patients and increase insulin sensitivity based on preliminary analysis from its Phase 2a trial of MSDC-0602, a novel insulin sensitizer.

Importantly, given the blood glucose (HbA1c) lowering shown in this short study, these data support the company's expectation of a >1.5 percent reduction in HbA1c potentially without the undesirable weight gain and other PPAR-related side-effects(1). According to the Diabetes Control and Complications Trial, as HbA1c is lowered, the risks of diabetic complications such as eye, nerve and heart disease is significantly reduced.

"This proof-of-concept trial affirmed the potential of this novel insulin sensitizer to lower blood glucose and increase insulin sensitivity without the side-effects found with currently marketed products," said Jerry Colca, Ph.D., president and Chief Scientific Officer of MSDC. "The data are encouraging and we are proceeding to design a Phase 2b study of longer duration."  

The safety, tolerability and efficacy of MSDC-0602 were evaluated in a 28-day, randomized, double-blind, comparator- and placebo-controlled, multi-dose study in 129 patients with type 2 diabetes. Patients were randomized to MSDC-0602, 45 mg of pioglitazone or placebo. No safety concerns were uncovered for any treatments and all treatments were well tolerated.  This study follows the completion of two Phase 1 trials in which no safety concerns were observed. Additional safety and expanded efficacy data will be obtained from a Phase 2b study of MSDC-0602 that is targeted to begin in the first quarter of 2012.

MSDC-0602 is an insulin sensitizer that is selective for a molecular target connecting mitochondrial metabolism to cell functio
'/>"/>

SOURCE Metabolic Solutions Development Company, LLC
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Regulus Therapeutics to Present New Advancements in microRNA Therapeutics for Treatment of Metabolic Diseases and Cancer
2. Study Uncovers Key Success Factors and Common Failure Points for Launching New Metabolic Products in Todays Competitive Healthcare Market
3. BioRestorative Therapies Signs License Agreement With University of Utah to Obtain Adipose (Fat) Tissue for its ThermoStem Program to Treat Obesity and Metabolic Disorders
4. Metabolic Solutions Development Company to Present Recent Findings on the Therapeutic Potential of Increasing Brown Fat in the Treatment of Diabetes at Annual American Diabetes Association Conference
5. GT Life Sciences Broadens Intellectual Property Portfolio with Issuance of U.S. Patent on Core Computational Systems and Methods for Genomic-based Metabolic Modeling
6. Creating a Road Map for Successful Metabolic New Product Launches
7. Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting
8. Metabolic Solutions Development Company Launches Phase 2a Trial of Its Second Compound to Treat Type 2 Diabetes
9. Dave Anderson and William Thomsen Join SRI Internationals Center for Advanced Drug Research to Lead Programs in Proteomics and Metabolic Disease Drug Discovery
10. Bionovo Announces Publication Describing How Metabolic Adaptability Contributes to the Metastasis of Tumors
11. Metabolic Status Before Pregnancy Predicts Subsequent Gestational Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
(Date:1/15/2014)... 2014 Massachusetts General Hospital (MGH), the Broad ... announced today that they have launched a strategic ... targets and develop novel therapies for inflammatory bowel ... worldwide. The MGH-Broad-Amgen collaboration brings together scientists with ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2
... Calif., Jan. 28 Impact Medical Solutions, Inc. (OTC ... that Mr. Mark A. Billings has joined the Company,s ... Partner at Atwater Financial Group Inc., a Montreal-based financial ... small-cap companies. He is also the President and ...
... ticker symbol ,CDXP.OB, LA JOLLA, Calif., Jan. 28 ... that it has completed a corporate name change to ... change, the Over-the-Counter Bulletin Board will trade the Company,s ... Kuo, M.D., Cordex,s Chief Executive Officer commented, "We are ...
Cached Medicine Technology:Impact Medical Solutions Announces Appointment of New Director and Corporate Update 2Impact Medical Solutions Announces Appointment of New Director and Corporate Update 3Duska Therapeutics Completes Corporate Name Change to Cordex Pharma 2Duska Therapeutics Completes Corporate Name Change to Cordex Pharma 3
(Date:7/10/2014)... HealthDay Reporter THURSDAY, July 10, 2014 ... use of calorie information on menus, if it,s available, to ... U.S. study. Women in particular review the menu labeling, ... with the U.S. Centers for Disease Control and Prevention. ... to help choose their meal, compared with just under half ...
(Date:7/10/2014)... better prepared to respond to an active shooter incident ... study in the journal Prehospital and Disaster Medicine ... the EMS provider comfort level with respect to entering ... neutralized or working with law enforcement personnel during that ... shooting, the Virginia Tech campus shooting, the 2009 Fort ...
(Date:7/10/2014)... with a microchip-based device developed at the Massachusetts General ... MGH Cancer Center can be cultured to establish cell ... the July 11 issue of Science , an ... reflect a tumor,s genetic mutation over time and changing ... culture cells from the blood that represent those present ...
(Date:7/10/2014)... public health concerns in the United States, with 32 ... of 2012. As health problems such as childhood obesity ... discuss the problem. , A new study, led by ... School at Washington University in St. Louis, examined the ... Twitter conversations about the issue of overweight kids. , ...
(Date:7/10/2014)... and Human Services (HHS) has announced a three-year grant ... Center totaling $4.7 million to support a new national ... cancer. , Titled "Evidence-Conformant Oncology Care," the project ... enhance care for adult cancer patients with late-stage disease, ... utilization. , "We believe that the best ...
Breaking Medicine News(10 mins):Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 2Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 3Health News:Active shooter training increases comfort level of emergency responders 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3Health News:Study looks at how Twitter can be used to address specific health issues 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3
... has applauded the appeal success of the National ... National Institute for Health and Clinical Excellences (NICE) ... osteoporotic fracture, and has called for continuing efforts ... Guidance is made available. , As an ...
... Methods to identify a patient with a Do Not ... from written documentation practices to the use of color-coded ... of Hospital Medicine, a national effort to standardize color-coded ... status, allergy, fall risk, etc.), would remove current practice ...
... 18, 2007 -- The Association for Professionals ... announced a series of new educational initiatives ... include Clostridium difficile-associated disease and the three ... Medicaid Services (CMS) have classified as preventable ...
... explain why older people are prone to dehydration during ... Older adults don,t drink enough water and become dehydrated ... coordinate sensory signals about thirst, a new Australian study ... signals from the body or the interpretation of these ...
... Tampa, FL (Dec. 18, 2007) -- A University of ... treated in utero a rare but potentially devastating condition ... and can rupture during labor, leaving the baby without ... as vasa previa is frequently deadly for newborns. ...
... 2007) New research published in the December issue ... shows that outcomes of high-risk cancer operations in 80-year-olds ... published survival statistics, which may lead to unrealistic expectations ... With this limited information, elderly patients and their physicians ...
Cached Medicine News:Health News:APIC launches 'Targeting Zero' initiative to eradicate infections deemed preventable by CMS 2Health News:Lack of Strong Thirst Signals Leads Elderly to Drink Too Little 2Health News:Lack of Strong Thirst Signals Leads Elderly to Drink Too Little 3Health News:Fetal surgeon shows for first time that laser procedure may treat vasa previa 2Health News:Fetal surgeon shows for first time that laser procedure may treat vasa previa 3Health News:Study finds outcomes of high-risk cancer operations in 80-year-olds worse than reported 2
...
... Miditron Junior II ... urinalysis analyser for standardised ... hardware and software features ... high performance and convenience ...
... The Assistant Free ... retractors utilizing Velcro® straps. ... of the surgeon's operative ... personnel. Three retractor styles ...
... for four corner fusion of the capitate, ... hand. The plate is intended for use ... of function due to SLAC and SNAC ... rheumatoid arthritis. When combined with the specially ...
Medicine Products: