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Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
Date:5/14/2009

ne loss.

"Our drug development program focuses on a different molecular target," said Colca. "We believe that selective activation of the novel mitochondrial target will produce a significantly improved safety profile for individuals with type 2 diabetes. If the results of this study can be successfully extended to longer trials, we might be able to achieve our long-term goal of a therapeutic option that could be used early in the course of the disease to prevent the otherwise inexorable progression of diabetes and its complications."

Colca and Rolf Kletzien, two West Michigan scientists who are developing the MSDC drug portfolio of more than 100 analogs, have spent much of their careers working on treatments for type 2 diabetes. Colca also was instrumental in the early development of pioglitazone, the active ingredient in Actos, during his tenure with Upjohn Company.

"We are pleased that our lead compound performed so well in the Phase IIa study," said Mark Olesnavage, chief executive officer of MSDC. "The preliminary Phase IIa results match our pre-clinical studies that suggested that this compound can deliver significant metabolic benefit without some of the complications inherent in current therapies."

Additional safety and expanded efficacy data will be gathered in a 90-day, multinational Phase IIb study that is planned for late 2009.

According to the American Diabetes Association, approximately $1 in every 10 health care dollars spent is attributed to diabetes. While an estimated 17.9 million Americans have been diagnosed with diabetes, 6.3 million people (or nearly one in four) are unaware that they have the disease.

There were 1.6 million new cases of diabetes in the United States during 2007. This growth rate of 7 percent continues to outpace the population growth and has been described by many health care professionals as an epidemic.

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SOURCE Metabolic Solutions Development Company
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