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Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
Date:5/14/2009

Results show improved insulin sensitivity and lower glucose levels

without the side effects of current therapies

KALAMAZOO, Mich., May 14 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC) announced today that its lead compound, MSDC-0160, can improve insulin sensitivity and lower blood glucose levels in humans without the side effects of current therapies when taken over a 28-day period, according to preliminary data derived from the company's Phase IIa clinical trial.

"This preliminary data confirms that a PPAR-sparing thiazolidinedione (TZD) can improve insulin sensitivity and lower glucose similar to a traditional TZD," said Dr. Jerry Colca, president and chief scientific officer of MSDC. "These results are contrary to the commonly accepted theory of how leading diabetes drugs work and support our theory surrounding PPAR-sparing TZDs that led us to develop this lead compound and our drug portfolio. These results further validate our ongoing development efforts with follow-on compounds." The company plans to file an Investigational New Drug Application with the Food and Drug Administration for a second-generation compound by the end of 2009.

Nearly 100 patients participated in this double-blind, placebo and active-controlled, multicenter clinical trial conducted in the United States. This Phase IIa clinical trial follows two successful Phase I trials that validated earlier indications of an improved pharmacokinetic and safety profile of MSDC-0160.

Similar to Actos, MSDC-0160 lowered the circulation of fatty acids and significantly increased good (HDL) cholesterol. Unlike Actos, MSDC-0160 did not decrease the levels of circulating blood cells and did not produce an increase in body weight.

Complications from the leading type 2 diabetic therapies include weight gain and edema as well as the potential for congestive heart failure and bo
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SOURCE Metabolic Solutions Development Company
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