Navigation Links
Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
Date:5/14/2009

Results show improved insulin sensitivity and lower glucose levels

without the side effects of current therapies

KALAMAZOO, Mich., May 14 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC) announced today that its lead compound, MSDC-0160, can improve insulin sensitivity and lower blood glucose levels in humans without the side effects of current therapies when taken over a 28-day period, according to preliminary data derived from the company's Phase IIa clinical trial.

"This preliminary data confirms that a PPAR-sparing thiazolidinedione (TZD) can improve insulin sensitivity and lower glucose similar to a traditional TZD," said Dr. Jerry Colca, president and chief scientific officer of MSDC. "These results are contrary to the commonly accepted theory of how leading diabetes drugs work and support our theory surrounding PPAR-sparing TZDs that led us to develop this lead compound and our drug portfolio. These results further validate our ongoing development efforts with follow-on compounds." The company plans to file an Investigational New Drug Application with the Food and Drug Administration for a second-generation compound by the end of 2009.

Nearly 100 patients participated in this double-blind, placebo and active-controlled, multicenter clinical trial conducted in the United States. This Phase IIa clinical trial follows two successful Phase I trials that validated earlier indications of an improved pharmacokinetic and safety profile of MSDC-0160.

Similar to Actos, MSDC-0160 lowered the circulation of fatty acids and significantly increased good (HDL) cholesterol. Unlike Actos, MSDC-0160 did not decrease the levels of circulating blood cells and did not produce an increase in body weight.

Complications from the leading type 2 diabetic therapies include weight gain and edema as well as the potential for congestive heart failure and bo
'/>"/>

SOURCE Metabolic Solutions Development Company
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate
2. Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
3. Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidones Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events
4. Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat
5. NAFLD AND NASH Linked to Metabolic Syndrome and Cardiovascular Disease
6. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
7. The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management
8. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
9. ePharmaSolutions Clinical Trial Investigator Portal Wins Bio-IT World 2009 Best Practice Award
10. MedNet Solutions to Share Industry Expertise at the 13th Annual EDC & Beyond Conference in Orlando, FL
11. Facet Solutions, Inc. Expands U.S. Pivotal Study With Next Generation Implant System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (NYSE: RMD ), a pioneer and innovator in ... sleep apnea solutions specifically for women, is launching a new ... night,s sleep. The Better Sleep For Women ... just part of living a busy life. It will encourage ... health, essential to not only living an active lifestyle but ...
(Date:10/1/2014)... Oct. 1, 2014 NeuroCall, Inc., ("NeuroCall") announced ... its Telestroke and Teleneurology services. Dr. Ricardo Garcia-Rivera ... "We are extremely proud that our quality of service ... continue to provide lifesaving support and continuity of care ... throughout the United States ." ...
(Date:10/1/2014)...  Varian Medical Systems (NYSE: VAR ) ... fourth quarter of fiscal year 2014 following the close ... news release will be followed by a teleconference available ... news release and a link to the conference call ... www.varian.com/investor .  To access the teleconference call and ...
Breaking Medicine Technology:ResMed Launches Initiative to Help Women Get Better Sleep 2ResMed Launches Initiative to Help Women Get Better Sleep 3NeuroCall Awarded Joint Commission Accreditation 2Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2
... Puma Biotechnology, Inc., a development stage biopharmaceutical ... license the worldwide commercial rights to neratinib, a ... transduction through the epidermal growth factor receptors, ErbB1 ... is being studied in the neoadjuvant, adjuvant and ...
... Corp. (OTCQB: CYCA), leading the way to cost effective ... Erik Stephansen to President of its eHealth division.  Mr. ... part of the company,s recent launch of their CyttaConnect™ ... network and its partners, FDA approved Bluetooth medical devices. ...
Cached Medicine Technology:Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 2Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 3Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 4Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 5New Leader for CyttaConnect™ Medical Monitoring eHealth Division 2New Leader for CyttaConnect™ Medical Monitoring eHealth Division 3
(Date:10/1/2014)... (PRWEB) October 01, 2014 Between 23 ... in the U.S., according to figures from the National ... Diseases Association (AARDA), and many of them have something ... of having undiagnosed celiac disease. Gluten Free Therapeutics, ... awareness of undiagnosed celiac disease by publishing a series ...
(Date:10/1/2014)... 01, 2014 Diet Doc understands that many ... lose weight and their dieting attempts could be easily sabotaged ... hormone diet treatments into their programs as a ... see fast and effective weight loss results, it also allows ... habits to maintain their weight for the future. , Earlier ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Anti Aging ... and skin rejuvenating destination of choice, is announcing a ... October through to December. , “We’re doing this because ... possible to our top skin clinic in Toronto,” says ... do so much at Anti Aging Clinic, including laser ...
(Date:10/1/2014)... On Sept. 9, Chapín Coffee was selected ... Stewart American Made Awards (MSAMAs), an annual competition in ... the fields of crafts, design, food and style. ... in the MSAMAs, which celebrates entrepreneurs and artisans who ... communities and changing the way we shop, work and ...
(Date:10/1/2014)... 2014 Nordic Naturals is kicking ... special cause. The campaign—“Buy One Bottle. Help Two ... Veterans, a nonprofit organization that helps rebuild the ... dogs that would otherwise face euthanasia. From October ... support monthly donations of Nordic Naturals omega-3s to ...
Breaking Medicine News(10 mins):Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2
... , , , SEATTLE, July 17 ... by exacerbating conditions like hypertension, stress and fatigue, but also by causing people ... , Physicians at The Polyclinic in Seattle are offering suggestions for ... health. , , Don, t put ...
... , WASHINGTON, July 17 The Association ... Director of Policy and Public Affairs, in response to the AMA,s endorsement ... American Medical Association has sold out patients and the profession by endorsing ... "Why did the AMA do it? For a few dollars increase ...
... , , , ... (Nasdaq: NGSX ) announced today that Bruce A. Peacock has ... on his responsibilities as CEO of privately-held Alba Therapeutics. , ... no opportune time to resign, I feel confident that NeurogesX is well ...
... and avoided vitamin B deficiency , FRIDAY, July ... gastric bypass surgery helps patients lose weight faster and ... Probiotics are the "good" bacteria found in yogurt and ... University School of Medicine study included 44 patients who ...
... , CAMBRIDGE, Mass., July 17 Biopure Corporation ... The Nasdaq Stock Market, by letter dated July 17, 2009, that its ... because of concerns raised by the Company,s filing for protection under Chapter ... of business on July 28, 2009. , , ...
... , Cabinet Secretaries Kathleen Sebelius, Hilda L. ... community forum and hold m edi ... WASHINGTON , July 17 U.S. Department of ... U.S. Department of Agriculture Secretary Tom Vilsack and U.S. Department of Veterans Affairs Secretary Eric ...
Cached Medicine News:Health News:How to Afford Health Care in Hard Times 2Health News:Doctors: AMA Has Sold Out Patients & the Profession For A Few Dollars 2Health News:NeurogesX Announces Resignation of Bruce A. Peacock from Board of Directors 2Health News:NeurogesX Announces Resignation of Bruce A. Peacock from Board of Directors 3Health News:NeurogesX Announces Resignation of Bruce A. Peacock from Board of Directors 4Health News:Top Obama administration officials to hold rural health community forum 2
Inquire...
Microseal 'F' foil, seals plates for cold storage (or cycling >25l), disposable, pkg of 100...
Sterilization: sterilized Yes...
Effective adhesive, may be removed from plate without residue. Transparent film for easy visual monitoring of samples...
Medicine Products: