Navigation Links
Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
Date:5/14/2009

Results show improved insulin sensitivity and lower glucose levels

without the side effects of current therapies

KALAMAZOO, Mich., May 14 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC) announced today that its lead compound, MSDC-0160, can improve insulin sensitivity and lower blood glucose levels in humans without the side effects of current therapies when taken over a 28-day period, according to preliminary data derived from the company's Phase IIa clinical trial.

"This preliminary data confirms that a PPAR-sparing thiazolidinedione (TZD) can improve insulin sensitivity and lower glucose similar to a traditional TZD," said Dr. Jerry Colca, president and chief scientific officer of MSDC. "These results are contrary to the commonly accepted theory of how leading diabetes drugs work and support our theory surrounding PPAR-sparing TZDs that led us to develop this lead compound and our drug portfolio. These results further validate our ongoing development efforts with follow-on compounds." The company plans to file an Investigational New Drug Application with the Food and Drug Administration for a second-generation compound by the end of 2009.

Nearly 100 patients participated in this double-blind, placebo and active-controlled, multicenter clinical trial conducted in the United States. This Phase IIa clinical trial follows two successful Phase I trials that validated earlier indications of an improved pharmacokinetic and safety profile of MSDC-0160.

Similar to Actos, MSDC-0160 lowered the circulation of fatty acids and significantly increased good (HDL) cholesterol. Unlike Actos, MSDC-0160 did not decrease the levels of circulating blood cells and did not produce an increase in body weight.

Complications from the leading type 2 diabetic therapies include weight gain and edema as well as the potential for congestive heart failure and bo
'/>"/>

SOURCE Metabolic Solutions Development Company
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate
2. Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
3. Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidones Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events
4. Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat
5. NAFLD AND NASH Linked to Metabolic Syndrome and Cardiovascular Disease
6. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
7. The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management
8. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
9. ePharmaSolutions Clinical Trial Investigator Portal Wins Bio-IT World 2009 Best Practice Award
10. MedNet Solutions to Share Industry Expertise at the 13th Annual EDC & Beyond Conference in Orlando, FL
11. Facet Solutions, Inc. Expands U.S. Pivotal Study With Next Generation Implant System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... , Aug. 19, 2014 According to Kalorama ... needed to make Big Data in healthcare a reality, ... As part of the American Recovery and Reinvestment Act, ... record (EMR) projects and penalties will start applying soon ... Information, in its complete study of the EMR industry, ...
(Date:8/19/2014)...  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) will webcast management ... and Regeneron will host an IR Thematic Conference Call on Alirocumab ... 2014 , Baird 2014 Healthcare Conference at 4:05 ... , Citi,s 9 th Annual Biotech Conference at ... , Morgan Stanley Global Healthcare Conference at 8:45 ...
(Date:8/19/2014)... and MENLO PARK, Calif. , ... DMPI) ("DelMar" "the company") announced today a protocol amendment to ... been filed with the U.S. Food and Drug Administration (FDA) ... has been opened at three clinical trial sites in ... confirmed that gross proceeds of US$2.9 million have been raised ...
Breaking Medicine Technology:Kalorama: EMR Paves the Way for Big Data 2Kalorama: EMR Paves the Way for Big Data 3DelMar Pharmaceuticals Provides Update on Glioblastoma Clinical Trial and Results of Warrant Tender Offer 2DelMar Pharmaceuticals Provides Update on Glioblastoma Clinical Trial and Results of Warrant Tender Offer 3DelMar Pharmaceuticals Provides Update on Glioblastoma Clinical Trial and Results of Warrant Tender Offer 4DelMar Pharmaceuticals Provides Update on Glioblastoma Clinical Trial and Results of Warrant Tender Offer 5DelMar Pharmaceuticals Provides Update on Glioblastoma Clinical Trial and Results of Warrant Tender Offer 6DelMar Pharmaceuticals Provides Update on Glioblastoma Clinical Trial and Results of Warrant Tender Offer 7
... Oct. 6 Complete,Genomics Inc., a newly launched, ... Systems Biology (ISB) today announced their,partnership to conduct ... of the project, Complete Genomics will use its ... samples provided by,ISB. Then, once proof-of-concept has been ...
... will host a conference call today, Monday, October ... to review the outcome of the interim analysis ... known as D9902B),clinical trial of PROVENGE(R) (sipuleucel-T), the ... advanced prostate,cancer., Those interested may ...
Cached Medicine Technology:Complete Genomics and the Institute for Systems Biology Announce Partnership to Conduct the First Human Genome Population Study 2Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial 2
(Date:8/20/2014)... (PRWEB) August 20, 2014 This ... line of software defined networking, high availability cloud ... portfolio of Resellers, while allowing OPEN-V to sell ... is pleased to work with OPEN-V on this ... Donald Hows, manager distribution channels at storageFOUNDRY. "Nautilus ...
(Date:8/19/2014)... BambooIndustry.com, a well-known bamboo product manufacturer and retailer, ... recently. The company is excited to reveal the new items, ... for all clients. Now, every customer can get a discounted ... until August 30. , The company’s deckings are made ... for supreme durability. They are perfect for a dining room, ...
(Date:8/19/2014)... Crosley Law Firm, PC has reached a confidential ... Star Bakery for an undisclosed amount. The two claimants, Pete ... of 2011, respectively. The injuries were caused by two different ... to the left hand of each man. , At the ... short-staffed, having lost 200 of its, 500 workers in connection ...
(Date:8/19/2014)... (PRWEB) August 20, 2014 Recently, Skmen.com, an ... assortment of 2014 bohemian dresses . In addition to ... these elegant items. Now, all of them are available at ... puts emphasis on product design and quality. Its beautiful bohemian ... purple, blue and many others. Owing to its top quality ...
(Date:8/19/2014)... involved in multitasking and ways to train it have ... Institut universitaire de griatrie de Montral and the University ... predict the effectiveness of this training. Cooking while having ... or driving while listening to a radio show ... lives. Unfortunately, it decreases with age, which makes it ...
Breaking Medicine News(10 mins):Health News:storageFOUNDRY and Open-V OzoneStack Announce Bilateral Distribution Agreement 2Health News:storageFOUNDRY and Open-V OzoneStack Announce Bilateral Distribution Agreement 3Health News:Promotional Bamboo Deckings from Well-known Online Supplier BambooIndustry.com 2Health News:Crosley Law Firm Reaches Settlement for Hand Amputation Victims at Commercial Bakery 2Health News:2014 Bohemian Dresses Now for Sale at Skmen.com 2Health News:Targeted brain training may help you multitask better 2
... NEW YORK, Aug. 11 Healthcare reform has become a hot button ... one organization,s attempts to clear the air and separate fact from fiction. ... http://inr.mediaseed.tv/oneClip_C/?feed=_QhsLVZADdDFnJstv e QtY97yVQFUg6so , ... and photos for free and unrestricted use at http://www.medi ...
... counters effects of hormone therapy, study finds , TUESDAY, ... has worked well in a trial of men whose ... taking for prostate cancer, researchers report. , The drug, ... hopes to market for fracture prevention, not only in ...
... PHILADELPHIA A new study conducted at the ... in Philadelphia, Pennsylvania shows an investigational, orally-inhaled therapy ... phase three FREEDOM-301 trial for the orally-inhaled migraine ... from symptoms such as pain, nausea and light ...
... team approach to preventive healthcare delivery for older adults ... Institute improves health and quality of life, decreased emergency ... second year the new model saved money for the ... in the third year, a year after the home-based ...
... , , , ... 11 Masimo (Nasdaq: MASI ), the ... pulse oximetry, and Oridion (SIX Swiss Exchange: ORIDN), a ... an agreement to establish compatibility and connectivity between Oridion ...
... Fla., Aug. 11 Jeff Korte, former Major with the Florida Division ... Investigative Unit (SIU) for Litigation Solutions, LLC. , ... enforcement experience to Litigation Solutions, spending the past 20 years with the ... in 2008. , , During his tenure ...
Cached Medicine News:Health News:New Bone-Building Drug Promising Against Prostate Cancer 2Health News:New Bone-Building Drug Promising Against Prostate Cancer 3Health News:Aging with GRACE: New health care delivery model improves outcomes, saves money 2Health News:Aging with GRACE: New health care delivery model improves outcomes, saves money 3Health News:Masimo and Oridion Sign Connectivity Agreement to Integrate Capnostream(TM)20 Portable Bedside Monitors into the Masimo Patient SafetyNet(TM) System 2Health News:Masimo and Oridion Sign Connectivity Agreement to Integrate Capnostream(TM)20 Portable Bedside Monitors into the Masimo Patient SafetyNet(TM) System 3Health News:Masimo and Oridion Sign Connectivity Agreement to Integrate Capnostream(TM)20 Portable Bedside Monitors into the Masimo Patient SafetyNet(TM) System 4Health News:Masimo and Oridion Sign Connectivity Agreement to Integrate Capnostream(TM)20 Portable Bedside Monitors into the Masimo Patient SafetyNet(TM) System 5Health News:Masimo and Oridion Sign Connectivity Agreement to Integrate Capnostream(TM)20 Portable Bedside Monitors into the Masimo Patient SafetyNet(TM) System 6Health News:Jeff Korte Named as SIU Director, Litigation Solutions, LLC 2
Delicate Desmarres lid retractors, round serrated handle, very thin blades, polished finish, size 1....
2.0 mm cup , straight shaft, Flat handle, length 125.0 mm....
Size 4 - 2.25 mm...
The Storz Protege is an anterior segment unit only....
Medicine Products: