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Metabolex Initiates Phase 1 Trial of MBX-2982
Date:3/26/2008

es Association estimates that there were approximately 20.8 million people in the United States with diabetes in 2005, making up 9.6 percent of the adult population. From 1995 through 2005, newly-diagnosed cases of diabetes among American adults increased by 81 percent. According to estimates from the ADA, approximately 11 percent of U.S. healthcare dollars are spent on treating diabetes. Type 2 diabetes accounts for roughly 90 to 95 percent of diabetic cases.

About Metabolex

Metabolex is a privately-held biopharmaceutical company focused on the discovery and development of proprietary new medicines for the treatment of metabolic diseases, with an emphasis on type 2 diabetes. Metabolex has drawn on its deep understanding of diabetes to create a large database of genes involved in diabetes and to build a rich pipeline of product candidates and drug discovery targets. The company has four clinical-stage compounds: MBX-102/JNJ 39659100, which has recently completed a Phase 2/3 trial; MBX-2044, which has completed a Phase 2a trial; MBX-8025, currently being studied in a Phase 2 trial in patients with dyslipidemia; and MBX-2982, which has just commenced a Phase 1 trial. Ortho-McNeil, Inc. has the exclusive right to develop and commercialize MBX-102/JNJ 39659100. For additional information about Metabolex and its development pipeline, visit http://www.metabolex.com.


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