Navigation Links
Mesoblast Cleared to Begin First Phase 2 Clinical Trial for Eye Diseases
Date:10/24/2011

MELBOURNE, Australia, Oct. 24, 2011 /PRNewswire/ --

Key Points

  • Mesoblast receives regulatory clearance to begin Phase 2 trial for wet Age-related Macular Degeneration (AMD)
  • Trial will be performed at Singapore National Eye Centre, combining Mesoblast's allogeneic ("off-the-shelf") cells with anti-VEGF agent
  • Wet AMD, the leading cause of blindness in industrialized countries, has different forms in Asia and North America/Europe
  • Anti-VEGF agents are less effective in Asian form of wet AMD
  • Mesoblast's allogeneic cells may be effective for both Asian and North American/European forms of wet AMD
  • Commencing this trial in Singapore is in line with Mesoblast's evolving clinical and manufacturing strategies

Regenerative medicine company Mesoblast Limited (ASX: MSB) today announced that it has received regulatory clearance from the Singapore Health Sciences Authority (HSA) to commence the first Phase 2 trial of its proprietary allogeneic (off-the-shelf) adult stem cell therapy for patients with proliferation of leaky blood vessels in the eyes – neovascular ("wet") Age-related Macular Degeneration (AMD). Wet AMD causes sudden and severe central vision loss and accounts for approximately 90 percent of all blindness in the elderly. Mesoblast is developing a stem cell therapeutic product for treating various vascular diseases of the eye, including wet AMD and diabetic macular edema (DME).

In North America, the prevalence of wet AMD is estimated to grow to nearly 3 million by 2020, from 1.7 million today, with about 200,000 new cases diagnosed each year. The current standard-of-care for wet AMD in North America is repeated intraocular injections using an anti-vascular endothelial growth factor (anti-VEGF) agent, such as Lucentis and Avastin. However, treatment needs to be maintained long-term since cessation of repeated injections results in rapid disease r
'/>"/>

SOURCE Mesoblast Limited
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Mesoblast Receives Clearance to Begin First European Trial of Allogeneic or Off-The-Shelf Stem Cell Treatment for Heart Attacks
2. Coapt Systems Launches FDA Cleared Novielle Voice (TM) for Restoration of Voice Loss
3. Pivotal Clinical Data Published for the Only Laser Phototherapy Device Cleared by the FDA for Hair Growth
4. ZyStor Therapeutics, Inc. Cleared to Begin Clinical Trial for Targeted Protein Therapeutic for the Treatment of Pompe Disease
5. Palomar to Commercialize FDA Cleared Over-The-Counter Home Use Wrinkle Treatment Laser Device Without Johnson & Johnson
6. Texas Cardiac Arrhythmia Institute at St. Davids Medical Center First in the United States to Utilize Newly FDA-Cleared CARTO(R) 3 Navigation System
7. Zargis Cardioscan Cleared for Sale in Canada
8. Zargis StethAssist & Zargis Cardioscan Cleared for Sale in Australia
9. FDA Clears Three Additional Antimicrobials for Use on TREK Sensititre(R) In Vitro Diagnostic (IVD) MIC Susceptibility Plates: Minocycline and Telavancin Used to Treat MRSA and Other Infections; and Tigecycline, Now Cleared for Streptococcus Pneumoni
10. Zargis to Launch FDA-Cleared Lung Sounds Analysis Technology from Stethographics, Inc.
11. Luminex Corporation Launches New FDA Cleared Pharmacogenetic Diagnostic Test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a specialty ... disease and overall health is pleased to provide you with ... outlook for 2015 from the CEO, Mr. Eugene Bortoluzzi ... like to take this opportunity to share with you the ...
(Date:1/22/2015)... MINNEAPOLIS , Jan. 22, 2015  Bio-Techne Corporation (NASDAQ: ... launched Ella, the first member of the new Simple ... ProteinSimple brand.  This launch represents the re-branding of the ... The Simple Plex platform is a transformative immunoassay technology ...
(Date:1/22/2015)... 2015 Increasing sophistication among enterprise buyers of language ... in 2015, says Moravia CMO, Renato ... by market research firm Common Sense Advisory, 15 percent ... translation and localization needs. "From a language industry perspective, ...
Breaking Medicine Technology:Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... Four years since the release of their debut ... the marriage of Avasa & Matthew Love – the duo are ... for release through White Swan Records on February 24, 2015. , ... sacred path available to all of us to walk out of ...
(Date:1/22/2015)... As interest in the value of spiritual ... worldwide, Rev. Eric J. Hall , president and CEO ... will be the keynote speaker on January 27 at an ... system. , The conference, “Hope and Resilience: Innovative and Interdisciplinary ...
(Date:1/22/2015)... 2015 Lower-Auto-Insurance.com has released a new blog post ... car for reducing the costs of an auto insurance policy ... able to get lower prices for their vehicle insurance policies. The ... in determining policy costs. Because of this, drivers should always ...
(Date:12/26/2014)... The US represents the largest market for ... GlobalData’s forecast estimates that sales of branded therapies were $2.23 ... the high incidence of the disease, high drug treatment rate, ... China. Increased sales of CRC therapies over the forecast period ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... Haneef, the man from Bangalore in southern India, continues . ... a small act of indiscretion, it looks like. He had allowed ... players in the failed Glasgow bombing. ,Intercepted when he ... the Glasgow incident, Haneef has been seeing his hopes soar only ...
... can more than double the risk of developing kidney cancer ... is a repeated loss and gain of body weight due ... aged between 50 and 79 for almost eight years to ... waist size to those with the large waistlines. ...
... chain 'PizzaExpress' has been named the most vegan-friendly food chain ... by the animal rights group for its cheese-free pizzas, the ... organisations recognised by PETA for 'animal-friendly progress'. ... and the first restaurant was opened in Wardour Street in ...
... fast food joint in Miami, Florida . ,The ... revealed that she has been hooked to the idea of ... ,"That was part of my L.A. education - on Sundays ... (cars)... FatBurger was, like, the centrepiece for it all," Contactmusic ...
... Combining medicines with the right food could improve the ... costs of treating patients, experts say . ... Ezra Cohen, MD, have released their expert comments after ... with fatty food, rather than on an empty stomach, ...
... the Varanavasi Village Panchayat near Kanchipuram in Tamil Nadu ... . ,Aghast over an ever-increasing trend of ... to ban the entry and consumption of tobacco products. ... consuming tobacco products like cigarette and gutka. Hence, the ...
Cached Medicine News:Health News:Haneefs Visa Revoked by Australia 2Health News:Right Foods Could Improve Drug Effectiveness, Lower Drug Costs 2Health News:Village Panchayat in Tamil Nadu Bans Tobacco Consumption 2
... introduces new high precision femtosecond laser technology ... opportunity to offer their patients a safer, ... creating the corneal flap. By using ... IntraLASIK software, surgeons may avoid the complications ...
... Teco Diagnostics manufactures fine urine chemistry ... urine chemistry reagent strips from start ... offer more economical prices compared to ... quality. Teco Diagnostics urine reagent strips ...
... Long term complications associated with diabetes ... the health and quality of life of ... costs. These complications are known to be ... The discovery that the level of haemoglobin ...
The Lifestream Plus Cholesterol Monitor provides you with a comprehensive tool to help you monitor your cholesterol as part of your wellness program....
Medicine Products: