Navigation Links
Merrimack Pharmaceuticals' Preclinical Research Shows MM-111 Restores Sensitivity To Chemotherapy And HER2-targeted Treatment In Gastric Cancer Model
Date:4/10/2013

CAMBRIDGE, Mass., April 10, 2013 /PRNewswire/ -- Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK) today announced preclinical study results showing that the novel bispecific therapy MM-111 restored tumor sensitivity to the chemotherapy agent, paclitaxel, and HER2-targeted treatment, trastuzumab, in a HER2+ gastric cancer model. The research was presented as part of the American Association for Cancer Research's 2013 Annual Meeting in Washington, DC, April 6-10, 2013.

Overexpression of the HER2 (ErbB2) cell surface receptor has been reported in 10-25 percent of gastric and esophageal cancers. The HER2 receptor triggers tumor growth and survival when it binds together with an additional receptor known as HER3 (ErbB3) and another protein called heregulin. HER3 expression has been associated with poor prognosis in gastric cancer. MM-111 is designed to anchor to both receptors, HER2 and HER3, on the cell surface and block heregulin's ability to transmit tumor growth signals, thus inhibiting the tumor cell's ability to thrive.

"The protein heregulin can often cause resistance to standard chemotherapy and targeted treatments in gastric tumors that express both HER2 and HER3," said Ulrik Nielsen , PhD, Co-Founder and Chief Scientific Officer of Merrimack. "We are encouraged to see that this resistance is overcome in preclinical models when MM-111 is used in combination with trastuzumab and paclitaxel."

Merrimack is initiating a Phase 2 study testing MM-111 in combination with paclitaxel or with paclitaxel and trastuzumab for the treatment of advanced gastric, esophageal and gastroesophageal junction (GEJ) cancers.  Merrimack is also currently conducting a Phase 1 study of MM-111 across multiple HER2+ tumors, including breast, colorectal, gas
'/>"/>

SOURCE Merrimack Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Merrimack Pharmaceuticals Preclinical Research Shows MM-121 Restores Sensitivity to Anti-Estrogen Therapy and Delays Onset of Treatment Resistance in ER-Positive Breast Cancer Model
2. Merrimack Pharmaceuticals Announces Top-Line Results From A Single Arm Phase 2 Advanced Lung Cancer Study In Patients With Resistance To An Anti-EGFR Tyrosine Kinase Inhibitor
3. Merrimack Pharmaceuticals To Present Phase I Data On MM-302 And Preclinical Data On Companion Diagnostics Both For The Treatment Of HER2-Positive Breast Cancer
4. Inovio Pharmaceuticals & U.S. Army Receive $3.5 Million Biodefense Grant to Further Develop Mass Vaccination Device
5. Faruqi & Faruqi, LLP is Investigating Peregrine Pharmaceuticals Inc. on Behalf of its Shareholders - PPHM
6. scPharmaceuticals LLC Announces Strategic Partnership with Sensile Medical to Develop Novel Heart Failure Treatment Aimed to Reduce Readmission Rates
7. Arena Pharmaceuticals Initiates Phase 1 Clinical Trial of APD334 for Autoimmune Diseases
8. Covis Pharmaceuticals, Inc Named US Distributor For Five Additional Products
9. Vanda Pharmaceuticals to Present at the BioCentury Future Leaders in the Biotech Industry Conference
10. Regeneron Pharmaceuticals Announces Expansion in New Yorks Hudson Valley
11. Valeant Pharmaceuticals Provides Update to Recent Event
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... , Germany , and ... -- , Exclusive global license ... for SF3B1 mutations, including next-generation sequencing (NGS) gene panels, ... to be targeted by new test, indicate favorable prognosis ... syndromes  QIAGEN sees potential for developing companion ...
(Date:7/24/2014)... July 24, 2014  Mettler-Toledo International Inc. (NYSE: ... 2014.  Provided below are the highlights: , ... quarter compared with the prior year. Reported sales increased ... , Net earnings per diluted share as reported (EPS) ... of 2013. Adjusted EPS was $2.57, an increase of ...
(Date:7/24/2014)... VIEW, Calif. , July 24, 2014 /PRNewswire/ ... a leading provider of medication and supply management ... a conference call Thursday, July 31, to discuss ... , Omnicell Second Quarter 2014 earnings conference ... 1:30 p.m. PTWho:  , Randall Lipps, chairman, president ...
Breaking Medicine Technology:QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 2QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 3QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 4QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 5Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 14Omnicell to Release Second Quarter 2014 Earnings Results on July 31 2
... 2010 STAAR Surgical Company (Nasdaq: STAA ... invasive ophthalmic products, today reported results for the third ... grew 6% to $13.2 million reflecting core product (IOLs ... decrease in defocused product revenue as compared to the ...
... Nov. 2, 2010 Kensey Nash Corporation (Nasdaq: ... investor conferences in November.   Michael Celano, ... presentation, at the Oppenheimer 21st Annual Healthcare Conference at ... at 2:10 p.m. (ET).  To hear the live webcast ...
Cached Medicine Technology:STAAR Surgical Reports Continued Double Digit Core Revenue Growth 2STAAR Surgical Reports Continued Double Digit Core Revenue Growth 3STAAR Surgical Reports Continued Double Digit Core Revenue Growth 4STAAR Surgical Reports Continued Double Digit Core Revenue Growth 5STAAR Surgical Reports Continued Double Digit Core Revenue Growth 6STAAR Surgical Reports Continued Double Digit Core Revenue Growth 7STAAR Surgical Reports Continued Double Digit Core Revenue Growth 8STAAR Surgical Reports Continued Double Digit Core Revenue Growth 9STAAR Surgical Reports Continued Double Digit Core Revenue Growth 10STAAR Surgical Reports Continued Double Digit Core Revenue Growth 11STAAR Surgical Reports Continued Double Digit Core Revenue Growth 12STAAR Surgical Reports Continued Double Digit Core Revenue Growth 13STAAR Surgical Reports Continued Double Digit Core Revenue Growth 14STAAR Surgical Reports Continued Double Digit Core Revenue Growth 15STAAR Surgical Reports Continued Double Digit Core Revenue Growth 16STAAR Surgical Reports Continued Double Digit Core Revenue Growth 17
(Date:7/26/2014)... Artificial lift market report defines and segments the artificial lift ... artificial lift market in Europe is estimated to grow from ... 2018, at a CAGR of 8.8% from 2013 to 2018. ... market report, to get an idea of in-depth analysis provided. ... Artificial lift market, and is supported by various tables and ...
(Date:7/26/2014)... iFitDress.com, a popular supplier of wedding dresses and special ... of high quality party outfits. Additionally, it has launched ... are now provided at discounted prices, up to 69 ... leading suppliers in the international market. According to its ... have flattering looks and fine craftsmanship. They are ...
(Date:7/26/2014)... (HealthDay News) -- Pools can provide much-needed relief from ... if they swallow too much chlorinated water, experts warn. ... little ones to get water in their mouth. Some ... despite warnings from their parents. Although swallowing a ... for parents to realize that ingesting too much can ...
(Date:7/26/2014)... WA (PRWEB) July 26, 2014 As ... design trends are changing based on 3 factors: smaller ... of several top bathroom trend of 2014 lists, ... enjoying increased popularity. Amerec , a leading manufacturer ... in steam bathing largely due to smaller spaces and ...
(Date:7/26/2014)... (PRWEB) July 26, 2014 As reported ... on July 23rd, new research by Palo Alto Networks ... rewrite their playbook, now focusing more on businesses and ... who have become increasingly wise to their tactics over ... and CEO/CTO, Joe Caruso, talks about the evolution of ...
Breaking Medicine News(10 mins):Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 5Health News:High Quality Wholesale Party Dresses Online at iFitDress.com 2Health News:Don't Let Kids Drink Pool Water 2Health News:Amerec Finds Bathroom Design Trends Change Based on Water Consumption and Other Factors 2Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 2Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 3Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 4Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 5Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 6
... May 14 This month, HealthFocus(R),International, the global ... knowledge, is launching their U.S.A. HealthFocus Trend,Study. This ... and,critical insights on the consumer, quest for health ... shows some interesting possibilities,for the role of diet ...
... ANN ARBOR, Mich.---Race is not a factor in the ... records had somewhat longer tenures before being fired than ... study shows. , The University of Michigan study ... coaches in the National Basketball Association. The study found ...
... An analysis by the Aspen,Institute has found gaps in ... John McCain and Barack Obama even as each of ... improving health,care in the United States., The Institute,s ... campaign. The questionnaire and the principles that guided the,analysis ...
... just as likely to have mental problems or drug addictions ... study ever conducted of women convicted of sexual offences in ... 8,500 men were convicted of sexual offences in Sweden. Given ... the factors specific to female sex offenders has been scant. ...
... HealthSouth,Corporation (NYSE: HLS ) announced today that ... to be held May 21-22 in New,York City. HealthSouth,s ... at 8:30 a.m. EDT. The presentation will be webcast ... http://www.healthsouth.com ., In addition, HealthSouth will ...
... Cancer Centers of North,Carolina,s diagnostic imaging service has ... result of a recent survey by the American ... F. Reilly and Dr. K. Kolby Sidhu lead,the ... diagnostic and therapeutic radiology services, including,Computed Tomography (CT) ...
Cached Medicine News:Health News:For Shoppers, Nutrition has a Role in Treating Illness 2Health News:Racism not an issue in firing of NBA coaches 2Health News:Presidential Candidates' Health Care Plans Lack Key Reform Elements, Aspen Institute Finds 2Health News:Presidential Candidates' Health Care Plans Lack Key Reform Elements, Aspen Institute Finds 3Health News:Presidential Candidates' Health Care Plans Lack Key Reform Elements, Aspen Institute Finds 4Health News:Female sex offenders often have mental problems 2Health News:Cancer Centers of North Carolina Receives Prestigious Accreditation 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: