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Merrimack Pharmaceuticals' Phase 1 Research Supports MM-121 Potential For Investigation As Combination With Chemotherapy In Patients With Advanced Solid Tumors
Date:6/4/2013

d tumors.
Session Title: General Poster Session: Developmental Therapeutics - Clinical Pharmacology and Experimental Therapeutics
Presenter: Monica Arnedos , MD, Institut Gustave Roussy, Paris, France

In studying the safety of MM-121 in combination with gemcitabine (Arm A), carboplatin (Arm B),  pemetrexed (Arm C) and cabazitaxel (Arm D) for subjects with advanced cancer, patients were treated in a dose escalation "3+3" design. MM-121 was administered weekly in combination with these cytotoxic agents to assess the safety, tolerability and pharmacokinetics of the antibody. Doses were escalated until the maximum tolerated dose (MTD) was identified and/or the combination was shown to be tolerable at the highest planned doses. Secondary objectives included determining the objective response rate, clinical benefit rate, pharmacokinetics and immunogenicity of MM-121. No MTD was identified for the combination of MM-121 and standard doses of gemcitabine, pemetrexed and cabazitaxel; a MTD of carboplatin (AUC 5) was identified in combination with the recommended dose of MM-121 (40 mg/kg loading, followed by 20 mg/kg weekly maintenance). The two dose limiting toxicities observed in combination with carboplatin were one grade 3-4 prolonged thrombocytopenia and one grade 3 maculopapular rash.

Overall adverse events reported for MM-121 in combination with these cytotoxic agents were similar to adverse events reported for the cytotoxic agents as single agents. Common adverse events included diarrhea, nausea, fatigue and anemia.

The combination of MM-121 and the cytotoxic agents evaluated in this study showed preliminary activity (16% of patients achieved a partial response).

For full details on the study, please view the full poster on our

SOURCE Merrimack Pharmaceuticals, Inc.
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