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Merck Serono Completes Enrollment in the REFLEX Trial of Rebif(R) in Patients at Risk of Developing Multiple Sclerosis
Date:9/16/2008

roven effective in all three key measures of treatment effectiveness: MRI lesion area and activity*, relapse rates and disability progression. The safety profile of Rebif(R) is supported by a robust, ongoing clinical development and post-marketing program and a 10-year record of use by MS patients.

The REFLEX trial is being conducted with the new formulation of Rebif(R). The new formulation of Rebif(R) was approved in the European Union in August 2007 and in Canada in September 2007 and is now marketed in all EU countries and in Canada. The new formulation of Rebif(R) is not available in the United States.

* The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

About Rebif(R)

Rebif(R) (interferon beta-1a) is a disease-modifying drug used to treat relapsing forms of multiple sclerosis (MS) and is similar to the interferon beta protein produced by the human body. The efficacy of Rebif(R) in chronic progressive MS has not been established. Interferons are thought to help modulate the body's immune system and reduce inflammation. The exact mechanism is unknown.

Rebif(R), which was approved in Europe in 1998 and in the US in 2002, is registered in more than 80 countries worldwide. Rebif(R) has been proven to delay the progression of disability, reduce the frequency of relapses and reduce MRI lesion activity and area*. Rebif(R) is available in a 22 micrograms and 44 micrograms ready-to-use pre-filled syringe and a titration pack (8.8 micrograms).

Rebif(R) should be used with caution in patients with a history of depression, liver disease and seizures. Most commonly reported side effects are flu-like symptoms, injection site disorders, elevation of liver enzymes and blood cell abnormalities. Patients, especially those with depression, seizure disorders, or liver problems, should discuss treatment with Rebif(R) with their doctors. For more info
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SOURCE Merck Serono International S A
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