Navigation Links
Merck Serono Completes Enrollment in the REFLEX Trial of Rebif(R) in Patients at Risk of Developing Multiple Sclerosis
Date:9/16/2008

GENEVA, Sept. 17 /PRNewswire/ -- Merck Serono, a division of Merck KGaA, Darmstadt, Germany, announced today that patient enrollment has been completed in the REFLEX trial (Rebif FLEXible dosing in early multiple sclerosis). This randomized, double-blind, placebo-controlled, international Phase III trial is designed to evaluate the therapeutic benefit of Rebif(R) (interferon beta-1a) on the time to conversion to multiple sclerosis (MS) in people with a first clinical event suggestive of the disease.

"It has been demonstrated that treatment with interferon beta can reduce the risk of developing multiple sclerosis," said Anton Hoos, Executive Vice President, Global Development, Merck Serono. "However, additional research still needs to be conducted in this area and we believe the REFLEX study will provide valuable insights."

A total of 517 patients considered at risk of developing MS due to a recently experienced isolated demyelinating event (e.g. optic neuritis, myelopathy or brainstem syndrome) and having magnetic resonance imaging (MRI) brain scans consistent with early signs of MS have been enrolled in the REFLEX trial. Study participants were randomized in a 1:1:1 ratio to receive either Rebif(R) 44 micrograms three times a week, Rebif(R) 44 micrograms once a week, or placebo as a subcutaneous injection. Patients will be treated for a period of 24 months, or up to the time when they experience a second attack leading to a diagnosis of clinically definite MS. At this point, patients are offered open-label treatment with Rebif(R) 44 micrograms three times a week.

The primary endpoint of the REFLEX trial is time to conversion to MS, according to the McDonald criteria. Further endpoints include time to conversion to clinically definite MS (the main secondary endpoint), assessments of MRI brain scans, clinical relapses and disability progression.

Rebif(R) is currently approved for the treatment of relapsing forms of MS. It has been p
'/>"/>

SOURCE Merck Serono International S A
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Diakron Licenses Anticoagulant Drug Candidate from Merck & Co., Inc.
2. MicroDose Technologies Announces Achievement of Phase I Clinical Milestone Triggering First Milestone Payment Under Collaboration with Merck & Co., Inc.
3. NicOx Announces Initiation of First Phase 1 Study of Investigational Nitric Oxide-Donating Agent in Hypertensive Patients by Merck & Co., Inc.
4. Iomai and Merck & Co., Inc. Evaluate Use of Iomai Immunostimulant Patch
5. Microbicide Developer Receives License for Novel HIV Microbicide Candidate From Merck & Co., Inc.
6. Parker Waichman Alonso LLP and Affiliated Lawfirms Have Filed a Class Action Lawsuit in the United States District Court for the Eastern District of New York Against Merck & Co., Inc. and Schering-Plough Corporation
7. Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.
8. MJFF and Merck Serono (EMD Serono in North America) Join Forces on $2-Million Initiative to Drive Treatments for PD-Related Cognitive Dysfunction and Mood Disorders
9. GeoVax Labs, Inc. Comments on Discontinuance of Mercks HIV Vaccine Trial
10. Merck/Gilead Once-A-Day AIDS Pill Not Available in Most Places - AHF Urges Speed-Up of Registrations
11. CuraGen Completes Enrollment in Phase II Trial of CR011-vcMMAE in Metastatic Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... --  Memorial Hermann Health System and The University ... new partnership to provide a new level of specialized breast ... the greater Houston area. ... provider of professional breast radiology services for five of Memorial ... The Woodlands , Northeast, Southwest and ...
(Date:8/21/2014)...  eRelevance Corporation ( www.erelevancecorp.com ), a progressive ... has completed integration with Nextech, a popular Electronic ... Dermatology practices. "Integration allows our service ... using Nextech," stated Bob Fabbio , co-founder ... the EMR we are able to automatically target ...
(Date:8/21/2014)... 21, 2014 /CNW/ - Eisai Limited is pleased to support ... first-of-its-kind comic book available in Canada . ... specifically to educate children and their parents about epilepsy, the ... affecting more than 300,000 Canadians. Eisai is guided by a ... in which the patient is central – there was a ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2
... March 2, 2011 Accumetrics, Inc., a privately-held developer ... and easy-to-use point-of-care diagnostic system for measuring platelet reactivity ... has signed an agreement with Portola Pharmaceuticals, Inc. to ... use in clinical trials. The VerifyNow System ...
... 2, 2011 Naviscan, Inc., announces the European ... scanner at two prestigious radiology conferences in Vienna. ... Breast Imaging (EUSOBI) Annual Scientific Meeting, a podium ... Emission Mammography) data demonstrating PEM,s ability to reduce ...
Cached Medicine Technology:Accumetrics Signs Development & Supply Agreement With Portola Pharmaceuticals, Inc. 2Naviscan Announces European Launch of Positron Emission Mammography 2
(Date:8/21/2014)... NV (PRWEB) August 21, 2014 ... Association for Packaging and Processing Technologies. They deliver ... the view into a whole new world of ... engaged attendees, interactive education, and the latest technology ... solutions from exhibitors. This year at Pack Expo ...
(Date:8/21/2014)... 22, 2014 BambooIndustry.com is an internationally ... company has recently unveiled its new collection of elegant ... made for customers who are looking for high quality ... are offered with great savings (up to 29 percent ... access these cheap products. , The company’s bamboo ...
(Date:8/21/2014)... Sterling Heights, MI (PRWEB) August 21, 2014 ... regarding emails informing a taxpayer that their federal tax ... the email domain appears to come from the IRS, ... unsuspecting victims to provide personal and financial information. , ... few years now, an uptick in phishing activity is ...
(Date:8/21/2014)... in the coronary arteries of chronic kidney disease patients ... according to a new study in the Journal ... ). Researchers at the Johns Hopkins Bloomberg School of ... commonly used measures of subclinical atherosclerosis in predicting the ... , Approximately 50 percent of all patients with chronic ...
(Date:8/21/2014)... August 21, 2014 Pulmonary Hypertension ... an Education Forum for PH patients and families ... Pulmonary Hypertension Association – the country’s ... ways to prevent and cure pulmonary hypertension (PH) ... the functioning of the heart and can lead ...
Breaking Medicine News(10 mins):Health News:Absolute I&D Provides Discounted Labor for Pack Expo Chicago 2Health News:Buy Elegant Bamboo Floorings from Internationally Well-known Supplier BambooIndustry.com 2Health News:Beware Of Phony “Tax Payment Rejected” IRS Emails 2Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Pulmonary Hypertension Association Goes On the Road to Houston With an Education Forum for PH Patients and Families to Help Fight Rare Lung Disease 2Health News:Pulmonary Hypertension Association Goes On the Road to Houston With an Education Forum for PH Patients and Families to Help Fight Rare Lung Disease 3
... of acres of farmland affected by last October,s red mud ... threat to a bountiful harvest, not toxic metals. In a ... also describe an inexpensive decontamination strategy using the mineral gypsum, ... note that a dam burst at a factory processing aluminum ...
... espionage agents probing an enemy,s fortifications, scientists are snooping ... that plants use to protect themselves from diseases. The ... natural defenses and enhance the safety and security of ... an article in the current edition of Chemical & ...
... Teenage girls and young women infected with HIV get pregnant ... HIV-negative peers, according to new research led by Johns Hopkins ... on an analysis of records from 181 patients with HIV, ... years, will be published in the Feb. 2 issue of ...
... keep hospital patients safe and continually improve the overall ... figure out a way to get physicians more involved ... patient care make their contributions to improvement efforts essential," ... patient safety expert and co-author of a commentary published ...
... Figures from a recently compiled report for 2009-2010 show ... students made a $6.8 million economic impact in the ... Education Centers. Specifically, AHEC faculty from UofL provided ... a total of $124,363 in living and travel expenses ...
... A targeted delivery combination selectively crosses the tight barrier that ... and bind to brain tumors, a research team led by ... reported in the January issue of the Journal of ... demonstrated that the targeted particles guide payloads to image tumors, ...
Cached Medicine News:Health News:Teens with HIV at high risk for pregnancy, complications 2Health News:More doctors must join nurses, administrators in leading efforts to improve patient safety, outcomes 2Health News:UofL Area Health Education Centers' faculty, students make $6.8 million economic impact 2Health News:UofL Area Health Education Centers' faculty, students make $6.8 million economic impact 3Health News:Targeted particle fools brain's guardian to reach tumors 2Health News:Targeted particle fools brain's guardian to reach tumors 3Health News:Targeted particle fools brain's guardian to reach tumors 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: