Memory Pharmaceuticals Highlights Progress with Key Programs at i...(marker of central nervous system(CNS) ac...),Health

Date:5/16/2008

marker of central nervous system (CNS) activity. The randomized, double-blind, placebo-controlled, cross-over study enrolled twelve healthy volunteers and evaluated three doses of MEM 1414 (250, 500 and 750 mg). In the study, the 500 and 750 mg doses produced a statistically significant increase in both the absolute and relative power of the EEG signal in the alpha frequency. In addition, the 250 mg dose produced a strong trend on certain electrodes. Effects were consistent with previous preclinical data and with the pharmacokinetic profile of MEM 1414, and supplement the preclinical data in models of inflammation. In these models, MEM 1414 demonstrated robust anti-inflammatory effects and suppressed cytokine release from human whole blood. Together, this data package supports both pro-cognitive and anti-inflammatory indications and provides guidance for dosing in future clinical trials.

MEM 68626 - Lead 5-HT6 Antagonist

MEM 68626 was nominated as the lead development candidate in the Company's 5-HT6 antagonist program. MEM 68626 is a novel, potent and selective antagonist of the 5-HT6 receptor, a validated target for the treatment of cognitive disorders. The compound has demonstrated efficacy in multiple preclinical models of cognition and obesity and has a favorable safety and toxicology profile in in vivo studies, with no cardiovascular or genetic toxicity issues. In addition, MEM 68626 has superior pharmaceutical-like properties and the compound's pharmacokinetic profile suggests the potential for once-daily, oral dosing.

2008 Program Goals

The Company confirmed its development goals for 2008:

-- Initiate a biomarker study for R3487/MEM 3454 this summer, with results

expected by early 2009

-- Complete and report top-line results for its Phase 2a trial of

R3487/MEM 3454 in cognitive impairment associated with schizophrenia

(CIAS) in the fourth quarter

-- Complete and report top-line re
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SOURCE Memory Pharmaceuticals Corp. Copyright©2008 PR Newswire. All rights reserved

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