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Medivation's Dimebon(TM) Stabilizes Behavioral Symptoms in Alzheimer's Disease Patients, Resulting in Reduced Caregiver Distress
Date:3/15/2008

mptoms of AD. During the study, the NPI was assessed at the beginning of the study and at weeks 12, 26, 39 and 52. Results showed that Dimebon-treated patients were significantly improved on the NPI total score compared with placebo-treated patients after six months (p=0.01) and one year of treatment (p=0.04). Dimebon treatment resulted in improvement over placebo on 8 of the 12 individual NPI subdomains.

Dimebon Reduced Caregiver Distress

Importantly, the behavioral improvements from Dimebon treatment resulted in a significant decrease in caregiver distress at 6 months (p=0.004) and at one year (p=0.04), compared to the distress of placebo patients' caregivers.

"Alzheimer's disease is a truly devastating disease, robbing patients of their mind and frequently causing significant behavioral problems, which dramatically impact the caregiver," said Lynn Seely, M.D., chief medical officer of Medivation. "There is a tremendous need for new drugs to treat this aspect of the disease, and we believe that Dimebon could provide an important new treatment option."

Dimebon Showed Statistically Significant Benefit Versus Placebo on All Key Efficacy Endpoints

Medivation previously announced efficacy and safety results from the pivotal, 12-month, double-blind, placebo-controlled trial of Dimebon in 183 patients with mild-to-moderate AD. Dimebon demonstrated statistically significant benefit versus placebo on all five efficacy endpoints at both six and 12 months. These endpoints spanned all of the most frequently studied aspects of Alzheimer's disease: cognition and memory, overall clinical function, activities of daily living and behavioral problems. Importantly, on every endpoint studied, the benefits of Dimebon over placebo at one year were stable or greater when compared to benefits at six months. No marketed drug for the treatment of Alzheimer's disease has shown this level of efficacy in published trials. Dimebon was well tolerated throughou
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SOURCE Medivation, Inc.
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